A5101066395- Cardiac Arrhythmias and Treatments
- Congenital Heart Disease Studies
- Cardiac pacing and defibrillation studies
- Bladder and Urothelial Cancer Treatments
- Cardiac electrophysiology and arrhythmias
- Prostate Cancer Treatment and Research
- Cardiac Valve Diseases and Treatments
- Urinary and Genital Oncology Studies
- Atrial Fibrillation Management and Outcomes
- Urologic and reproductive health conditions
- Genital Health and Disease
- Ovarian cancer diagnosis and treatment
- Cardiac Structural Anomalies and Repair
- Prostate Cancer Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Cardiovascular Function and Risk Factors
- Cancer Immunotherapy and Biomarkers
- Cardiomyopathy and Myosin Studies
- Sarcoma Diagnosis and Treatment
- Ion channel regulation and function
- Vascular anomalies and interventions
- Electrical Contact Performance and Analysis
- Cardiovascular Issues in Pregnancy
- Chemotherapy-induced organ toxicity mitigation
- PARP inhibition in cancer therapy
Shizuoka Children's Hospital
2014-2024
Institute of Cardiology
2014
Boston Children's Hospital
2011
Japanese Red Cross Society Wakayama Medical Center
2009-2010
Okayama University
1979-1990
Onomichi General Hospital
1989
AMA Computer University
1981
Kagawa Prefectural Central Hospital
1979
ABSTRACT Aims . Several recent studies have reported potassium sodium‐activated channel subfamily T member 1 ( KCNT1 ) mutations in epilepsy patients on quinidine therapy. The efficacy and safety of for treatment, however, remains controversial. Methods We herein report the cases four with treated quinidine. Results A reduction seizures more than 50% after treatment was observed one patient infancy migrating focal (EIMFS), whereas two EIMFS did not achieve apparent seizure reduction....
Ectopic atrial tachycardia (EAT) often resists medical therapy, making radiofrequency catheter ablation (RFCA) the preferred treatment. This study reviewed records of 35 patients who underwent electrophysiologic studies (EPS) and 39 RFCA procedures for EAT during a 10-year period. Of patients, 10 (28%) presented with decreased ventricular function tachycardia-induced cardiomyopathy (TIC). The originated on right side in 19 (54%) left remaining 16 (46%). sites included appendage (RAA) (n = 9,...
In Japan, the use of implantable cardioverter defibrillators (ICDs), cardiac resynchronization therapy with a biventricular pacemaker (CRTP) and CRT defibrillator (CRTD) in children has not been studied statistically, dual-chamber (DDD) pacemakers are still used for pediatric because current government regulations.Data were obtained from 15 children's 74 general hospitals through questionnaire survey regarding aforementioned therapies performed before 2012 Japanese (<16 years old). ICD, DDD,...
Left ventricular noncompaction (LVNC) is a hereditary type of cardiomyopathy. Although it associated with high morbidity and mortality, the related ion channel gene variants in children have not been fully investigated. This study aimed to elucidate genetic landscape LVNC identify genotype-phenotype correlations large Japanese cohort.We enrolled 206 from 2002 2017 Japan. was classified as follows: congenital heart defects, arrhythmia, dilated phenotype, or normal function. In patients, 182...
An increasing number of children are undergoing radiofrequency catheter ablation (RFCA) for tachyarrhythmia. However, infants and toddlers RFCA often resistant to medication or need eliminate arrhythmia substrate, the risks complications still high in toddlers. From April 2008 December 2016, 285 who underwent were stratified according body weight (group A, less than 10 kg, n = 22; group B, over 263) clinical features retrospectively reviewed these groups. Indications included drug-refractory...
Seventy-eight patients were treated with intravesical instillation of Thio-Tepa in an attempt to prevent postoperative recurrences bladder tumors. Fifty-six who given no preventive treatment against taken as the control group. The this series presented at Okayama University Hospital between 1961 and 1976 only first recurrence after primary operation was into consideration. There significant difference rates groups.
Asplenia syndrome is commonly associated with complex structural cardiac malformations, and junctional tachycardia (JT), which may compromise hemodynamic status, has been reported in association asplenia syndrome. 1 We report successful radiofrequency catheter ablation of reentrant JT a patient (PACE 2010; e43–e45)
Wolff‒Parkinson‒White (WPW) syndrome is characterized by an anomalous accessory pathway (AP) connecting the atrium and ventricle, leading to abnormal myocardial excitation cardiac arrhythmias. The effective refractory period (ERP) of AP crucial for risk stratification. Building on previous research indicating significance source‒sink mismatch mechanism in conduction, this study explored hypothesis that ERP involves such a relationship. To investigate this, computer simulations antegrade...
Abstract Background: The time constant of isovolumic relaxation is an established index ventricular relaxation, a major component diastolic function, even in single right ventricle. However, the specific echocardiographic parameters for estimating dysfunction are insufficient This study aimed to investigate indices associated with post-Fontan operation patients Methods: We included 39 hypoplastic left heart syndrome after Fontan ejection fraction ≥45% and preserved valve function. First,...
A near diploid clone derived from a rat liver cell line was continuously treated with various concentrations of 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB) in culture. By treatment 2.8 micrograms/ml, cells 41 chromosomes formed mode and which then shifted to 39. The chromosome numbers 5.4 micrograms/ml were widely distributed at early stages, but later the hypotetraploid region. Untreated control confirmed as diploid. Increased plating efficiency by 3'-Me-DAB well appearance large sized...
Congenital porto-systemic shunt (CPSS) is a rare disease and can cause fatal complications. Accurate angiographic assessment mandatory for proper treatment. Although technically difficult, we developed techniques assessed their accuracy. One technique came from evaluating patients with extrahepatic portal vein obstruction (EHPVO).We conducted single center retrospective study to evaluate the efficacy of diagnostic procedure CPSS EHPVO, its impact on patients' subsequent interventions...
背景：超低出生体重児（ELBWI）の救命率は近年著しく改善しているが，ELBWIにおける心疾患に対する治療報告はいまだ少ない．ELBWIに高肺血流性心疾患を合併し，長期呼吸管理を要した症例に対し，積極的治療を行い根治術に到達した4症例を報告する．症例：①女児．心房中隔欠損症：在胎29週504 g．抜管困難であり，生後2ヵ月より肺高血圧を呈したため，シルデナフィルを開始し，生後4ヵ月で根治術を施行した．②男児．完全型房室中隔欠損症：在胎26週670 g．21トリソミー．生後2ヵ月で肺動脈絞扼術を施行した後，生後4ヵ月に根治術を施行した．③男児．心室中隔欠損症：在胎27週412 g．生後6ヵ月で重度の肺高血圧を認め，酸素療法とシルデナフィルを開始した．生後11ヵ月で肺高血圧の改善を確認し，根治術を施行した．④女児．総動脈幹症：在胎29週752...
Abstract We report the case of an 11‐year‐old boy who was diagnosed with catecholaminergic polymorphic ventricular tachycardia (CPVT). The patient had a medical history three episodes syncope. last episode cardiac arrest while swimming. After resuscitation using automated external defibrillator, he placed under cerebral hypothermia, examined for long QT syndrome, and underwent insertion implantable cardioverter defibrillator. He subsequently discharged from hospital without any adverse...
人膀胱癌培養細胞株T24, 253Jの性ホルモン感受性を colony formation method で検討した. 6種類の性ホルモンおよび cnotrol である cortisol を5μg/ml～160μg/mlの各濃度で, 24時間および48時間, 細胞に接触させた. 7種類のステロイドホルモン中, estrone (E1), testosterone (T), dehydroepiandrosterone sulfate (DHEA-S), (F) の殺細胞効果が軽度であつたのに比し, estradiol-17β (E2) には高度の, progesterone (P) および estriol (E3) には中等度の殺細胞効果を認めた. 性ホルモンおよび に対する感受性については, T24細胞と253J細胞の間に有意差は認められなかつた. 両細胞に対する性ホルモンの殺細胞作用は濃度依存性および時間依存性を有するものであつた.