A5087278678- Congenital Heart Disease Studies
- Cardiac Valve Diseases and Treatments
- Cardiovascular Conditions and Treatments
- Coronary Artery Anomalies
- Pulmonary Hypertension Research and Treatments
- Cardiovascular and Diving-Related Complications
- Cardiac Arrhythmias and Treatments
- Mechanical Circulatory Support Devices
- Vascular anomalies and interventions
- Kawasaki Disease and Coronary Complications
- Cardiovascular Issues in Pregnancy
- Cardiac Structural Anomalies and Repair
- Cardiovascular Function and Risk Factors
- Aortic Disease and Treatment Approaches
- Coronary Interventions and Diagnostics
- Congenital heart defects research
- Tracheal and airway disorders
- Renal and Vascular Pathologies
- Infective Endocarditis Diagnosis and Management
- Wireless Power Transfer Systems
- Transplantation: Methods and Outcomes
- Cardiac Imaging and Diagnostics
- Central Venous Catheters and Hemodialysis
- Cerebrovascular and Carotid Artery Diseases
- Aortic aneurysm repair treatments
Showa University Hospital
2010-2024
Showa University
2009-2021
Showa University Northern Yokohama Hospital
2008-2019
Kyoto Prefectural University of Medicine
2019
Abbott (Sweden)
2015
Valve (United States)
2015
Cardiovascular Research Center
2013-2014
Cambridge University Press
2013
National Cerebral and Cardiovascular Center
1985-2010
Japan Pediatric Society
2010
Abstract Recently, GATA4 and NKX2.5 were reported as the disease genes of atrial septal defect (ASD) but relationship between locations their mutations phenotypes is not clear. We analyzed in 16 familial ASD cases, including four probands with atrioventricular conduction disturbance (AV block) two pulmonary stenosis (PS), by PCR direct sequencing, examined clinically. Five mutations, three identified 31.3% ASD, them novel. The without AV block S52F E359Xfs (c.1075delG) that was previously,...
We analyzed retrospectively the relationship between coagulation profile, and either hepatic function or hemodynamics, in patients who had undergone a Fontan-type procedure, comparing them, first, with control group of 12 without significant hemodynamic abnormality, and, second, 14 not Fontan but whose mean right atrial pressure exceeded 8 mmHg. Follow-up catheterization been performed all 30 submitted to operation. Prothrombin time, factor XIII, were significantly lower those procedure than...
The outcome of stent implantation and redilatation was investigated in 4 pediatric patients with 7 stenotic lesions the pulmonary vein (PV), paying particular attention to late neointimal proliferation. minimal diameter increased from 0.8-3.6 (2.3±1.1) mm 3.6-8.4 (5.1±1.6) immediately after implantation. Although pressure gradient across lesion not measured patient 4, 1-3, it decreased 4-34 (18±13) mmHg 3-15 (7±4) mmHg. Except for case who achieved a 8.4 initial dilatation, other 6 all...
Abstract Background : Pulse wave velocity (PWV) and ankle brachial index (ABI) are a useful method to estimate atherosclerosis in adults, while history of Kawasaki disease (KD) may be risk factor for later systemic arteries. PWV ABI patients with KD have not been reported. Method In total, 90 ranging age from 4 25 years who had previously, any time 1 month 19 ago, were studied. As control group, 119 other trivial cardiovascular diseases such as small ventricular, an atrial septal defect or...
Background: Medium- and long-term efficacy of intravascular stenting for congenital heart disease (CHD) has not been determined in Japan. Methods Results: The study comprised a retrospective survey Palmaz or Genesis stent implantation pulmonary artery stenosis (PA), aortic coarctation, superior inferior vena cava lesions (SIVC) from May 1995 to February 2009, occurring association with pre- postoperative CHD at 14 leading hospitals. Stents were implanted 255 patients 312 (PA, 253 199...
Pompe disease is an autosomal recessive, lysosomal glycogen storage caused by acid α-glucosidase deficiency. Infantile-onset (IOPD) the most severe form and characterized cardiomyopathy, respiratory distress, hepatomegaly, skeletal muscle weakness. Untreated, IOPD generally results in death within first year of life. Enzyme replacement therapy (ERT) with recombinant human alpha glucosidase (rhGAA) has been shown to markedly improve life expectancy patients IOPD. However, efficacy ERT...
Left ventricular noncompaction (LVNC) is a hereditary type of cardiomyopathy. Although it associated with high morbidity and mortality, the related ion channel gene variants in children have not been fully investigated. This study aimed to elucidate genetic landscape LVNC identify genotype-phenotype correlations large Japanese cohort.We enrolled 206 from 2002 2017 Japan. was classified as follows: congenital heart defects, arrhythmia, dilated phenotype, or normal function. In patients, 182...
We report on 5 patients who developed hemolysis (the Hemolysis group) following coil occlusion for PDA, and compare their data to 66 cases which were not complicated by despite residual leak No group). A significant with a heart murmur was more frequent in the group than group. The ratio of sum loop diameter coils minimal ductus (C/D) those persistent that needed second intervention (2.2 ± 0.4) significantly smaller (3.1 1.1). Persistent can occur if shunt remains after implantation small...
The factors that may determine the evolution of right coronary cusp prolapse (RCCP) and regurgitation (AR) associated with a ventricular septal defect in outlet septum (outlet VSD) have not been clarified.The Doppler echocardiograms 316 patients were grouped according to both development RCCP, values deformity index (RCCD) imbalance (R/L). All detected AR was </= slight, progressive RCCD <0.30 R/L <1.30. Moderate either >/=0.30 or >/=0.30. Rupture sinus Valsalva identified A significantly...
Background Coils are the only devices available for transcatheter occlusion of patent ductus arteriosus (PDA) in Japan. Since April 1999, we have introduced a 0.052-inch Gianturco coil (0.052-inch coil) to close PDA ≥2.5 mm. Methods and Results A retrospective survey outcome occlusions mm before after became found that (1) frequency among all candidates significantly increased availability (p<0.01); (2) deployment complicated by migration (p<0.01), prolonged procedure time (p<0.05) were...
Background:The aim of this study was to investigate the feasibility static balloon atrial septostomy (BAS) with double technique for infants. TMP PED catheter, newly designed BAS in small children, used 3 The catheter has a low profile, short and round shoulder, smooth deflation without slippage.Methods Results:Three infants (transposition great arteries, n=2; pulmonary atresia intact ventricular septum, n=1) underwent restrictive interatrial communication between December 2014 March 2015....
Abstract Transcatheter pulmonary valve replacement (TPVR), also known as percutaneous implantation, refers to a minimally invasive technique that replaces the by delivering an artificial prosthesis through catheter into diseased under guidance of X‐ray and/or echocardiogram while heart is still beating not arrested. In recent years, TPVR has achieved remarkable progress in device development, evidence‐based medicine proof and clinical experience. To update knowledge timely fashion, according...
Our purpose was to determine the feasibility and safety of transcatheter coil occlusion a perimembranous VSD.Transcatheter ventricular septal defect (VSD) may be useful treatment; however, there are few reports on its technical aspects outcome.We attempted closure VSD in 41 patients. We approached via right ventricle (RV) 16, left (LV) simultaneously deployed two coils from RV (RV/RV) three, two, or four LV (RV/LV) six. Coils (0.038'' flipper, 0.052'' Gianturco, 0.035'' platinum coil) were...
The Harmonization By Doing (HBD) program was established in 2003 as a partnership among stakeholders of academia, industry and regulatory agencies Japan the United States, with primary focus on streamlining processes global medical device development for cardiovascular devices. While HBD has traditionally focused devices intended to treat conditions prevalent adults, 2016, "HBD-for-Children" program, which focuses pediatric use lags behind that adults both countries.
Abstract We report a 3‐month‐old girl with Costelio syndrome complicating fatal hypertrophic obstructive cardio‐myopathy. She had typical findings of this syndrome, slight dyspnea and persistent wheezing. Doppler echocardiography revealed asymmetric septal hypertrophy systolic anterior movement the mitral leaflet. There was grade 1 regurgitation. Although once her heart failure been controlled medically, she died suddenly following deterioration condition. can complicate cardiomyopathy.
The etiology of Kawasaki disease (KD) remains unknown, although some infectious organism has been suggested as the cause. Recent studies suggest that bacterial toxins with superantigen activity are involved in its pathogenesis, but no specific toxin yet identified. Throat swabs for culture were obtained from 21 patients KD and 20 other febrile illnesses controls. Mitogenic supernatants individual strains was measured by lymphocyte proliferation assay. Sixty-one isolated patients, 62 control...
Coil occlusion has been widely indicated for the closure of patent ductus arteriosus (PDA). Although many reports have shown efficacy and safety coil occlusion, long-term outcome in patients remains controversial. Here, we analyzed with PDA Japan.We collected longitudinal data who underwent between 1995 2009. A total 310 occlusions were performed 298 PDA. The median minimum duct diameter was 1.4mm. Successful achieved 286 (96.0%), adverse events seen only 28 cases (9.0%). follow-up period 50...