A5010545013- Cardiac Structural Anomalies and Repair
- Congenital Heart Disease Studies
- Cardiac Valve Diseases and Treatments
- Pulmonary Hypertension Research and Treatments
- Mechanical Circulatory Support Devices
- Cardiac Arrhythmias and Treatments
- Cardiovascular Function and Risk Factors
- Cardiovascular Issues in Pregnancy
- Connective tissue disorders research
- Cardiomyopathy and Myosin Studies
- Cardiac Arrest and Resuscitation
- Cardiac pacing and defibrillation studies
- Pleural and Pulmonary Diseases
- Infectious Aortic and Vascular Conditions
- Heart Failure Treatment and Management
- Colorectal Cancer Surgical Treatments
- Cardiovascular and Diving-Related Complications
- Poisoning and overdose treatments
- Muscle Physiology and Disorders
- Liver Disease and Transplantation
- Cardiovascular Effects of Exercise
- Surgical Sutures and Adhesives
- Aortic Disease and Treatment Approaches
- Respiratory Support and Mechanisms
- Congenital heart defects research
Osaka University
2014-2025
Kanazawa Medical University
2018
Osaka City General Hospital
2014-2015
Kinan Hospital
2012-2014
Osaka International Cancer Institute
2013-2014
San Diego Cardiac Center
2014
Abstract A 50-year-old man presented with shortness of breath. The patient underwent ventricular septation for a single ventricle L-malposition the great arteries at 6 years age. Examinations revealed that calcified patch was torn and perforated, resulting in left-to-right shunt. We report rare case who survived after 40 ago reoperation due to patch.
Fibroblast-to-myofibroblast transition (FMT) is the primary inducer of cardiac fibrosis. ONO-1301, a synthetic prostacyclin agonist, reportedly promotes tissue fibrosis repair by enhancing anti-fibrotic cytokine production. We hypothesized that ONO-1301 attenuates pressure-overloaded modulating FMT and generated murine model via transverse aortic constriction (TAC) to evaluate in vivo effects ONO-1301. Cardiac fibrosis, left ventricular dilatation, systolic dysfunction were established 4...
Clinical outcomes of pulmonary arterial hypertension (PAH) may be improved using targeted delivery system. We investigated the efficacy ONO1301 (prostacyclin agonist) nanospheres (ONONS) in Sugen5416/hypoxia rat models PAH. The rats were injected with saline (control) or ONONS (n = 10, each) on days 21 and 28, respectively. Hepatocyte growth factor (HGF)-expressing fibroblasts inflammatory cytokines measured. Cardiac performance was assessed monitored vivo, Texas red-labeled nanoparticles....
Abstract OBJECTIVES The clinical significance of persistent end-diastolic forward flow (EDFF) after pulmonary valve replacement (PVR) remains unclear in patients with repaired tetralogy Fallot. This study aimed to identify the characteristics these and impact EDFF on outcomes. METHODS Of 46 consecutive who underwent PVR for moderate severe regurgitation between 2003 2019, 23 (50%) did not show before [group (−)]. In remaining PVR, was diminished 13 (28%) (+, −)] persisted 10 (22%) +)]....
Abstract OBJECTIVES This study aimed to identify the histological characteristics associated with bridge recovery using Berlin Heart EXCOR® (BHE) in paediatric patients <10 kg dilated cardiomyopathy. METHODS Of 10 consecutive cardiomyopathy who underwent BHE implantation between 2013 and 2018, 4 showed improvement left ventricular (LV) function, resulting successful explantation (recovery group). The remaining 6 persistent LV dysfunction heart transplantation (non-recovery following...
Atrial arrhythmia and right ventricular (RV) diastolic dysfunction are associated with increased morbidity mortality in patients repaired tetralogy of Fallot (TOF). This study was performed to determine whether the preoperative atrial (RA) volume can predict development after pulmonary valve replacement (PVR) TOF.Forty-seven consecutive adult TOF underwent PVR from 2003 2018. Seventeen showed Maze procedure concomitantly. The RA evaluated computed tomography image analysis software.The...
Loeys–Dietz syndrome (LDS) is a recognized connective tissue disorder characterized by progressive aortic aneurysm and dissection. Patients are at high risk of dissection or rupture an early age, but to our knowledge, surgery on the great arteries has never been attempted in neonatal period. We report case LDS with dilated pulmonary interrupted arch complex neonate. performed bilateral artery banding, 12 days after procedure, infant died distal portion banding sites following massive dilatation.
Key Teaching Points•Ectopic atrial tachycardia originating from aneurysms of the right appendage is very rare among children.•Aneurysms having structural abnormalities such as pectinate muscles and saccular form would prevent catheter insertion radiofrequency ablation.•Surgical treatment often effective for patients with aneurysm multiple tachycardia; however, location or size important surgical treatment.•A combination medications, surgery, ablation should be considered foci aneurysms. •Ectopic
Tissue-engineered vascular grafts (TEVGs) are in urgent demand for both adult and pediatric patients. Although several approaches have utilized smooth muscle cells (SMCs) endothelial as cell sources TEVGs, these a limited proliferative capacity that results an inability to reconstitute neotissues. Skeletal myoblasts attractive they possess high capacity, already being tested clinical trials patients with ischemic cardiomyopathy. Our previous study demonstrated periodic hydrostatic...
Colorectal anastomotic leakage is one of the most feared and fatal complications colorectal surgery. To date, no external coating material that can prevent has been developed. As myoblasts possess anti-inflammatory capacity improve wound healing, we developed a multilayered human skeletal muscle myoblast (HSMM) sheet by periodic exposure to supraphysiological hydrostatic pressure during repeated cell seeding. We assessed whether application an HSMM promote healing process after colonic...
Atrial function in Fontan patients is unknown. Our goal was to report the relationship of atrial with cardiac index and clinical outcome through longer follow-up periods.Twelve were followed up for over 20 years after their first operation. function, including expansion index, ejection fraction, passive fraction active examined using computed tomography. The failing analysed.Twelve included. median period operation 27 (range, 21-33) years, age those 33.5 24-60) years. There 6 male (50%)....
A 6-year-old boy with pulmonary regurgitation after complete repair of congenital heart disease underwent an alternative surgical for valve replacement. Trileaflet reconstruction using expanded polytetrafluoroethylene membrane is a clinically feasible technique in such young child whom large-sized bioprosthetic valves cannot be implanted.
Background:Pulmonary valve replacement (PVR) is a common reoperation, typically required approximately 10 years following right ventricular outflow tract reconstruction and especially true in cases of tetralogy Fallot. However, an improved prosthetic required.Methods Results:A fresh decellularized pulmonary allograft was used for PVR to correct regurgitation 35-year-old man 33 Fallot repair. The postoperative course short-term function were excellent. This the first case...
A 9-year-old patient with massive destruction of the mitral apparatus caused by active infective endocarditis underwent valve plasty using a modified commissural autologous pericardial patch repair. This procedure is clinically relevant and feasible technique for pediatric patients endocarditis.
新生児Marfan症候群は希少な疾患で，わが国においての文献的報告は12例に留まる．出生直後ないし乳児期早期より特徴的な外表奇形と重篤な心肺機能不全を呈し予後不良である．症例は5歳女児．日齢2に哺乳不良と嘔吐を主訴に他院に入院．クモ様指と老人様顔貌があり，心エコーにて大動脈基部拡大，僧帽弁逆流，僧帽弁逸脱が確認され，新生児Marfan症候群と診断された．日齢26に当科に紹介され，生後1ヵ月よりpropranolol，生後2ヵ月よりlosartanの内服を開始．さらに，利尿薬，アンジオテンシン変換酵素阻害薬を併用していたが僧帽弁閉鎖不全が進行し，5歳時に僧帽弁置換術が施行された．また，経過中，側彎の進行と水晶体亜脱臼がみられた．遺伝子検査でFBN1遺伝子の変異［Gly1013Arg］が認められた．手術所見では，僧帽弁は弁尖が全体に肥厚し，粘液腫様変性を呈していた．弁尖，弁下組織は切除し，St. Jude Medical valve 25...
Abstract Background Diaphragmatic hernia is a rare complication of ventricular assist device (VAD), mainly developing after explantation the device. We herein report case diaphragmatic that developed following implantation VAD. Case presentation A 4-month-old girl with diagnosis dilated cardiomyopathy underwent VAD for bridge to heart transplantation. Three months later, intermittent vomiting developed, and left-sided was confirmed on plain X-ray computed tomography. Without any findings...
Transhepatic approachで心臓カテーテル治療を行った2例を報告した．症例1（1歳1ヵ月，体重5.8kg）はファロー四徴，低形成肺動脈，姑息的右室流出路再建術後で，左肺動脈狭窄に対して経皮的血管形成術を行った．両側大腿静脈，右内頸静脈，右鎖骨下静脈の閉塞，および左上大静脈遺残のため，transhepatic approachを選択した．症例2（25歳，体重51kg）は多脾症で，屈曲蛇行した動脈管に対しコイル閉鎖術を行った．大動脈側からの動脈管へのアプロ－チは急角度のため留置用カテーテルの安定した操作が得られず，肺動脈側からのアプローチは下大静脈欠損，右内頸静脈閉塞のため困難で，transhepatic approachを選択した．...