A5019754480- Acute Myeloid Leukemia Research
- Retinoids in leukemia and cellular processes
- Quantum Chromodynamics and Particle Interactions
- Erythrocyte Function and Pathophysiology
- Particle physics theoretical and experimental studies
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- High-Energy Particle Collisions Research
- Immune Cell Function and Interaction
- Platelet Disorders and Treatments
- Trace Elements in Health
- Acute Lymphoblastic Leukemia research
- Ubiquitin and proteasome pathways
- SARS-CoV-2 and COVID-19 Research
- Chronic Lymphocytic Leukemia Research
- Protein Degradation and Inhibitors
- Lymphoma Diagnosis and Treatment
- Tuberculosis Research and Epidemiology
- Growth Hormone and Insulin-like Growth Factors
- EFL/ESL Teaching and Learning
- Cell Adhesion Molecules Research
- Monoclonal and Polyclonal Antibodies Research
- Chronic Myeloid Leukemia Treatments
- Glycosylation and Glycoproteins Research
Tohoku Medical and Pharmaceutical University Hospital
2018-2024
Tohoku Medical and Pharmaceutical University
2019-2024
The University of Tokyo
1989-2024
Tohoku University
2012-2022
Kitasato University
2007-2021
London Health Sciences Centre
2017-2018
Western University
2016-2017
Saitama Medical University
2016
Saiseikai Ibaraki Hospital
2015
University of Health and Allied Sciences
2013
The NF-E2-binding sites or Mafrecognition elements (MARE) are essentialcis-acting in the regulatory regions of erythroid-specific genes recognized by erythroid transcription factor NF-E2, composed p45 and MafK. Recently, two p45-related factors Nrf1 Nrf2 were isolated, they now collectively grouped as Cap'n' collar (CNC) family. CNC bind to MARE through heterodimer formation with small Maf proteins. We report here identification characterization a novel factor, Nrf3, encoding predicted...
Sorafenib, a kinase inhibitor active against various solid tumours, induces oxidative stress and ferroptosis, new form of necrosis, in some cancer cells. Clinically-applicable biomarkers that reflect the impact sorafenib on redox metabolism cells are lacking.We used gene expression microarrays, real-time PCR, immunoblot, protein-specific ELISA, reporter constructs encoding enzyme luciferase to study response panel sorafenib. Tumour explants prepared from surgical hepatocellular carcinoma...
Abstract MRL/Mp-lpr/lpr (MRL/lpr) mice spontaneously develop lethal glomerulonephritis (GN) similar to human lupus nephritis, associated with the expression of lymphoproliferation gene lpr. To examine whether a particular IgG subclass is responsible for development GN in these mice, first quantitative analysis subclasses serum and kidney eluates was performed. Although IgG2a dominant throughout lifespan IgG3 level three times higher than that at 16 wk age, which time onset severe GN. In sera...
The DONuT experiment collected data in 1997 and published first results 2000 based on four observed $ν_τ$ charged-current (CC) interactions. final analysis of the is presented this paper, $3.6 \times 10^{17}$ protons target using 800 GeV Tevatron beam at Fermilab. number CC interactions 9, from a total 578 neutrino We calculated energy-independent part tau-neutrino cross section ($ν+ \bar ν$), relative to well-known $ν_e$ $ν_μ$ sections. ratio $σ(ν_τ)$/$σ(ν_{e,μ})$ was found be...
Breast cancer resistance protein (BCRP/ABCG2) is a membrane-bound efflux transporter important in cellular detoxification and multidrug resistance. Some aryl hydrocarbon receptor (AHR) agonists were reported to induce BCRP expression human colon carcinoma cells. However, direct involvement of AHR transcriptional regulation remains unexplored. In this study, we show that induction by ligands occurs intestinal, liver, mammary cells primary colonocytes hepatocytes. Increased activity consistent...
Protein kinase B (PKB)/Akt reportedly plays a role in the survival and/or proliferation of cells. We identified novel protein, which binds to PKB, using yeast two-hybrid screening system. This association was demonstrated not only vivo by overexpressing both proteins or coimmunoprecipitation endogenous proteins, but also vitro glutathione S-transferase fusion proteins. Importantly, this protein specifically associates with C terminus PKB other AGC kinases and enhances phosphorylation...
B lymphocyte-induced maturation protein 1 (Blimp-1) is a key regulator for plasma cell differentiation. Prior to the terminal differentiation into cells, Blimp-1 expression suppressed in cells by transcription repressors BTB and CNC homology 2 (Bach2) lymphoma 6 (Bcl6). Bach2 binds Maf recognition element (MARE) of promoter upstream region gene (Prdm1) forming heterodimer with MafK. Bcl6 were found interact each other cells. While both possess domain which mediates protein-protein...
Abstract Fms‐like tyrosine kinase‐3 (FLT3) is a commonly mutated gene in acute myeloid leukemia (AML). The two most common mutations are the internal‐tandem duplication domain (ITD) mutation and kinase (TKD) mutation. FLT3‐ITD FLT3‐TKD exhibit distinct protein stability, cellular localization, intracellular signaling. To understand underlying mechanisms, we performed proximity labeling with TurboID to identify proteins that regulate or ‐TKD differently. We found BRCA1/BRCA2‐containing...
ABSTRACT Previous investigators have reported the occurrence of both allergic and non‐allergic systemic complications due to exposure formaldehyde gas. However, little is known about pathogenic link between formaldehyde‐induced clinical symptoms patch test results, or long‐term effects exposure. In present study, a questionnaire was administered 143 medical students, 60 them were tested by for at beginning end human anatomy laboratory course. Another group 76 students who had finished course...
Differentiation therapy using all-trans retinoic acid (ATRA) for acute promyelocytic leukemia (APL) is well established. However, because the narrow application and tolerance development of ATRA need to be improved, we searched another efficient myeloid differentiation inducer. Kinase activation involved in biology block. To identify novel inducers, used a Inhibitor Screening Library. Using nitroblue tetrazolium dye reduction assay real-time quantitative PCR NB4 APL cells, revealed that,...
Coherent double neutral-pion photoproduction on the deuteron, $\gamma{d}${$\to$}$\pi^0\pi^0{d}$, has been experimentally studied at incident photon energies ranging from 0.75 to 1.15 GeV. The total cross section as a function of $\gamma{d}$ center-of-mass energy shows resonance-like behavior, which peaks approximately 2.47 and 2.63 measured angular distribution deuteron emission is rather flat, cannot be reproduced by kinematics quasi-free $\pi^0\pi^0$ production with coalescence. In $\pi^0d...
Resistance to cytosine arabinoside (Ara-C) is a major problem in the treatment of patients with acute myeloid leukemia (AML). In order investigate mechanisms involved Ara-C resistance, gene expression profile Ara-C-resistant K562 human cells (K562/AC cells) was compared that Ara-C-sensitive (K562 by using cDNA microarray platform. Correspondence analysis demonstrated insulin-like growth factor I (IGF-I) upregulated K562/AC cells. The biological significance IGF-I overexpression further...