A5068706764- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Mycobacterium research and diagnosis
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Retinoids in leukemia and cellular processes
- Drug Transport and Resistance Mechanisms
- Clinical Laboratory Practices and Quality Control
- Hematological disorders and diagnostics
- Lymphoma Diagnosis and Treatment
- Hepatitis C virus research
- Hematopoietic Stem Cell Transplantation
- Tuberculosis Research and Epidemiology
- Folate and B Vitamins Research
- SARS-CoV-2 detection and testing
- RNA Interference and Gene Delivery
- Advanced Chemical Sensor Technologies
- Lung Cancer Treatments and Mutations
- Olfactory and Sensory Function Studies
- Hepatitis B Virus Studies
- DNA and Nucleic Acid Chemistry
- Colorectal Cancer Treatments and Studies
- Diagnosis and treatment of tuberculosis
- Liver Disease Diagnosis and Treatment
- Cancer therapeutics and mechanisms
Tokai University
2015-2024
Nitobe Bunka College
2023-2024
Tokai University Hospital
2001-2022
Toho University
2018
Kanagawa Dental University
2018
Ministry of Education, Culture, Sports, Science and Technology
2018
Creative Commons
2018
National Institutes of Health
2014
Biology of Infection
2007-2013
Hospital Clínic de Barcelona
2013
Artesunate (ART) is a semi-synthetic derivative of artemisinin, the active principle Chinese herb Artemisia annua. ART reveals remarkable activity against otherwise multidrug-resistant Plasmodium falciparum and P. vivax malaria. has now been analyzed for its anti-cancer 55 cell lines Developmental Therapeutics Program National Cancer Institute, USA. was most leukemia colon cancer (mean GI50 values: 1.11+/-0.56 microM 2.13+/-0.74 , respectively). Non-small lung showed highest mean value...
Three multicentre studies of reference intervals were conducted recently in Japan. The Committee on Common Reference Intervals the Japan Society Clinical Chemistry sought to establish common for 40 laboratory tests which measured three and regarded as well harmonized Japan.The study protocols comparable with recruitment mostly from hospital workers body mass index ≤28 no medications. Age sex distributions made equal obtain a final data size 6345 individuals. Between-subgroup differences...
Conventional automated hematology analyzers have limitations in platelet measurements such as poor accuracy and precision the low count range interference by nonplatelet particles. In order to improve it, newly developed XN-Series (Sysmex Corporation, Kobe, Japan) been installed with a new dedicated channel for analysis (PLT-F), which is based on fluorescence flow cytometry method uses of novel fluorescent dye specifically staining platelets. We evaluated basic performance this PLT-F...
Gene alterations are a well-established mechanism leading to drug resistance in acute leukemia cells. A full understanding of the mechanisms these cells will facilitate more effective chemotherapy. In this study, we investigated mechanism(s) human cell line MOLT-3 and its idarubicin-resistant derivative MOLT-3/IDR through complete mitochondrial nuclear DNA analyses. We identified genetic differences between two lines. The ND3 mutation site (p.Thr61Ile) sequence was unique Moreover, five...
A series of clinical isolates drug-resistant (DR) Acinetobacter baumannii with diverse drug susceptibility was detected from eight patients in the emergency intensive care unit Tokai University Hospital. The initial isolate obtained March 2010 (A. strain 1); subsequently, seven were strains 2-8) and one an air-fluidized bed used by five during 3 months August to November 2011. classified into three types antimicrobial resistance patterns (RRR, SRR SSR) according their (S) or (R) imipenem,...
Multidrug resistance is an important mechanism responsible for refractoriness of leukemia and worse outcome patients. Overexpression the multidrug gene, MDR1, prognostic relevance in acute myeloid leukemia, while its role lymphoblastic (ALL) still under debate. Single nucleotide polymorphisms (SNP) have been detected MDR1 gene. The C3435T polymorphism this gene seems to functional clinical consequences. In present investigation, we analyzed SNP drug prognosis human ALL. was 20 T-ALL cell...
Reports of the metabolomic characteristics esophageal cancer are limited. In present study, we thus conducted metabolome analysis paired tumor tissues (Ts) and non-tumor (NTs) using capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS). The Ts surrounding NTs were surgically excised pair-wise from 35 patients with cancer. Following tissue homogenization metabolite extraction, a total 110 compounds absolutely quantified by CE-TOFMS. We compared concentrations metabolites...
The purpose of this study is to compare the efficacy and safety combination therapy (HD-ECM) including high-dose cytarabine in initial induction with that (ECM) involving continuous administration for previously untreated, newly diagnosed patients AML at <18 years age. This a seamless Phase II-III clinical trial, consisting II III parts. In part, experimental treatment will be examined. Subsequently, HD-ECM standard ECM. primary endpoint early mortality rate. endpoints are 3-year event-free...
To assess the usefulness of ultrasonography in differential diagnosis cervical tuberculous lymphadenitis versus malignant lymph nodes. Ultrasonography nodes was performed with a real‐time linear scanner using 7.5‐ or 11‐MHz probe both. Ultrasonographic findings were retrospectively reviewed 73 patients: 49 lymphoma, 15 lymphadenitis, and 9 metastatic features specific to strong echoes (33.3%) an echogenic thin layer (86.7%). When had at least 1 these 2 features, diagnosed sensitivity 100%...
The promyelocytic leukemia–retinoic acid receptor α (PML-RARα) protein of acute leukemia (APL) is oncogenic in vivo. It has been hypothesized that the ability PML-RARα to inhibit RARα function through PML-dependent aberrant recruitment histone deacetylases (HDACs) and chromatin remodeling key initiating event for leukemogenesis. To elucidate role HDAC this process, we have generated HDAC1–RARα fusion proteins tested their activity oncogenicity vitro vivo transgenic mice (TM). In parallel,...
We examined the effects of suppressing multidrug resistance-associated protein (MRP) and resistance 1 (MDR1) gene expression in HCT-8DDP human colon cancer cell lines, which showed both cisplatin resistance. Hammerhead ribozymes, designed to cleave MRP mRNA (anti-MRP Rz) MDR1 (anti-MDR1 Rz), were transfected into cells. Drug sensitivity was estimated by MTT assay vitro. The HCT-8DDP/anti-MRP Rz cells more sensitive doxorubicin (DOX) etoposide (VP-16) 2.5- 4.1-fold, respectively, compared...