Keisuke Okamura

ORCID: 0000-0002-6702-7190
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About
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Research Areas
  • Pancreatic and Hepatic Oncology Research
  • Cholangiocarcinoma and Gallbladder Cancer Studies
  • Gallbladder and Bile Duct Disorders
  • Blood Pressure and Hypertension Studies
  • Neuroendocrine Tumor Research Advances
  • Pancreatitis Pathology and Treatment
  • Gastric Cancer Management and Outcomes
  • Esophageal and GI Pathology
  • Gastrointestinal Tumor Research and Treatment
  • Metastasis and carcinoma case studies
  • Hormonal Regulation and Hypertension
  • Cancer Mechanisms and Therapy
  • Gastrointestinal disorders and treatments
  • Pediatric Hepatobiliary Diseases and Treatments
  • Cancer Research and Treatments
  • Hepatocellular Carcinoma Treatment and Prognosis
  • Cancer therapeutics and mechanisms
  • Mast cells and histamine
  • Renal and Vascular Pathologies
  • Lung Cancer Research Studies
  • Renal cell carcinoma treatment
  • Viral-associated cancers and disorders
  • Biliary and Gastrointestinal Fistulas
  • Cardiac Imaging and Diagnostics
  • Adrenal Hormones and Disorders

Imamura Hospital
2024-2025

Fukuoka University
2013-2024

Kanagawa University
2024

Hokkaido University
2014-2023

Hokkaido hospital
2009-2023

Yan'an Hospital Affiliated To Kunming Medical University
2018

Kunming Medical University
2018

Yokohama National University
2018

Nagoya University
2017

Chang Gung Memorial Hospital
2017

Abstract Renal denervation is a promising new non-pharmacological treatment for resistant hypertension. However, there lack of data from Asian patients. The REQUIRE trial investigated the blood pressure-lowering efficacy renal in treated patients with hypertension Japan and South Korea. Adults (seated office pressure ≥150/90 mmHg 24-hour ambulatory systolic ≥140 mmHg) suitable artery anatomy were randomized to ultrasound or sham procedure. primary endpoint was change baseline at 3 months. A...

10.1038/s41440-021-00754-7 article EN cc-by Hypertension Research 2021-10-15

The high frequency of surgical site infections (SSIs) after hepato-pancreato-biliary (HPB) surgery is a problem that needs to be addressed. This prospective, randomized, controlled study examined whether perioperative prophylactic use antibiotics based on preoperative bile culture results in HPB could decrease SSI.Participants comprised 126 patients who underwent (bile duct, gallbladder, ampullary, or pancreatic) cancer with biliary reconstruction at Hokkaido University Hospital between...

10.1002/jhbp.453 article EN Journal of Hepato-Biliary-Pancreatic Sciences 2017-03-29

Objective The aim of this study was to examine the association between medication adherence and illness perceptions, explore factors associated with poor in atrial fibrillation (AF) patients receiving direct oral anticoagulants (DOACs) a real-world clinical setting. Methods An observational cross-sectional pilot conducted at single Japanese university hospital. One hundred twenty-nine who were diagnosed AF taking DOACs recruited from outpatients January 4th April 25th, 2017. We evaluated...

10.1371/journal.pone.0204814 article EN cc-by PLoS ONE 2018-09-28

Abstract The efficacy of preoperative neoadjuvant chemoradiotherapy ( NAC ) in cases pancreatic cancer with extremely poor prognoses has been reported. In this study, we aimed to identify novel biomarkers that reflect following using tertiary lymphoid organs TLO expressed the tumor microenvironment. Resected specimens were obtained from 140 patients. We retrospectively investigated clinical relevance by categorizing patients into those who underwent upfront surgery (surgery first [ SF ]) and...

10.1111/cas.14023 article EN cc-by-nc Cancer Science 2019-04-18

Renovascular hypertension (RVHT) is most commonly caused by renal artery stenosis (RAS) secondary to arteriosclerosis. Other causes of RVHT include fibromuscular dysplasia (FMD) and other rare causes, such as Takayasu arteritis (TA). A male patient in his early 20s presented with hypertension. Laboratory findings were positive for hypokalemia well elevations plasma renin activity aldosterone concentration. Plain computed tomography revealed atrophy the right kidney, magnetic resonance...

10.14740/jocmr6187 article EN Journal of Clinical Medicine Research 2025-03-01

// Takashi Ueno 1, 2 , Takahiro Tsuchikawa 1 Kanako C. Hatanaka Yutaka Tomoko Mitsuhashi Yoshitsugu Nakanishi Takehiro Noji Toru Nakamura Keisuke Okamura Yoshihiro Matsuno and Satoshi Hirano Department of Gastroenterological Surgery II, Division Surgery, Faculty Medicine, Graduate School Hokkaido University, Sapporo, Hokkaido, Japan Surgical Pathology, University Hospital, Correspondence to: Tsuchikawa, email: tsuchi-t@med.hokudai.ac.jp Keywords: extrahepatic cholangiocarcinoma; PD-L1; tumor...

10.18632/oncotarget.25050 article EN Oncotarget 2018-04-13

Abstract Background and Aim Lymph node metastasis is an important prognostic factor for intrahepatic cholangiocarcinoma (ICC), but accurate preoperative diagnosis difficult. The aim of this study was to measure the concentration serum carbohydrate antigen 19‐9 (s‐CA19‐9) as a predictor lymph metastasis. Methods In our department, curative‐intent hepatectomy ICC has been performed only once absence metastases in para‐aortic nodes (PALN) confirmed from intraoperative frozen‐section...

10.1111/jgh.14124 article EN Journal of Gastroenterology and Hepatology 2018-02-10

Inappropriate dosing of direct oral anticoagulants (DOACs) has been associated with clinical safety and efficacy; however, little is known about data an inappropriate DOAC in Japan. In addition, there no report which the appropriateness between prescription for inpatients outpatients was examined. this study, we aimed to investigate prevalence factors DOACs patients atrial fibrillation (AF).The retrospective cohort study conducted at a single Japanese university hospital. Both outpatients,...

10.1186/s40780-020-0157-z article EN cc-by Journal of Pharmaceutical Health Care and Sciences 2020-02-11

Whether concomitant hepatic artery resection (HAR) improves the prognosis for advanced perihilar cholangiocarcinoma remains controversial. The aim of present study was to compare short- and long-term surgical results HAR versus standard (SR) using propensity score matching.Among 209 patients with who underwent in our department, 28 HAR, remaining 181 SR. To adjust differences clinicopathological factors, including difficulty surgery, between groups, matching used at a 1:1 ratio, resulting...

10.1002/jhbp.363 article EN Journal of Hepato-Biliary-Pancreatic Sciences 2016-05-23

Laparoscopic spleen-preserving distal pancreatectomy (LSPDP) is an ideal procedure in selected patients with benign or low-grade malignant tumors the body/tail of pancreas. We describe our and experience splenic vessel-preserving LSPDP (SVP-LSPDP) a retrospective case series.Six consecutive underwent SVP-LSPDP from January 2011 to September 2013. evaluated courses artery by preoperative computed tomography applied individualized approach (the superior inferior approach) artery.All operations...

10.1097/sle.0000000000000182 article EN cc-by-nc-nd Surgical Laparoscopy Endoscopy & Percutaneous Techniques 2015-06-27

The surgical indications for patients with pancreatic head cancer (PHC) clinical portal vein (PV) invasion (cPV) remain controversial. present study aimed to determine the ability of computed tomography (CT) diagnose pathological PV involvement (pPV) in PHC.We evaluated morphological features (length and circumference) two sets diagnostic criteria cPV determined from preoperative CT findings 112 consecutive who underwent pancreatoduodenectomy PHC. This is listed UMIN Clinical Trials Registry...

10.1002/jhbp.387 article EN Journal of Hepato-Biliary-Pancreatic Sciences 2016-09-05

Abstract Background Conversion surgery ( CS ) is expected as a new therapeutic strategy for patients with unresectable pancreatic cancer UR ‐ PC ). We analyzed outcomes of and evaluated the survival benefit . Methods Thirty‐four diagnosed according to National Comprehensive Cancer Network guideline underwent in our hospital. Resectability was considered by multimodal images who nonsurgical treatment NST more than 6 months. performed only were judged be able undergo R0 resection. Results...

10.1002/jhbp.565 article EN Journal of Hepato-Biliary-Pancreatic Sciences 2018-05-24
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