A5033210375- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Thyroid Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Nutrition and Health in Aging
- Pelvic floor disorders treatments
- Colorectal Cancer Surgical Treatments
- Myasthenia Gravis and Thymoma
- Cancer Genomics and Diagnostics
- Tracheal and airway disorders
- Pituitary Gland Disorders and Treatments
- Diverticular Disease and Complications
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Immunotherapy and Biomarkers
- Thyroid and Parathyroid Surgery
- Immune cells in cancer
- Neuroendocrine Tumor Research Advances
- Renal cell carcinoma treatment
- Frailty in Older Adults
- Intraperitoneal and Appendiceal Malignancies
- Cancer Diagnosis and Treatment
- Pregnancy-related medical research
- Glioma Diagnosis and Treatment
- Bariatric Surgery and Outcomes
Red Cross Hospital
2023-2024
Japanese Red Cross Asahikawa Hospital
2023-2024
Akebono (Japan)
2024
Obihiro Kosei General Hospital
2019-2024
Hokkaido University
2016-2023
Krankenhaus vom Roten Kreuz
2023
Asahikawa City Hospital
2016
Gifu University
2006
Abstract The efficacy of preoperative neoadjuvant chemoradiotherapy ( NAC ) in cases pancreatic cancer with extremely poor prognoses has been reported. In this study, we aimed to identify novel biomarkers that reflect following using tertiary lymphoid organs TLO expressed the tumor microenvironment. Resected specimens were obtained from 140 patients. We retrospectively investigated clinical relevance by categorizing patients into those who underwent upfront surgery (surgery first [ SF ]) and...
Tumour budding is a risk factor for poor prognosis in various cancers. buds may present an epithelial-mesenchymal transition (EMT) morphological phenotype. This study aimed to elucidate the prognostic impact of tumour grade and its association with clinicopathological EMT-related features perihilar cholangiocarcinoma (PHCC) or distal (DCC).Subjects included 195 PHCC 115 DCC patients. The numbers different patients were stratified postoperative survival using recursive partitioning technique....
The epithelial–mesenchymal transition (EMT) contributes to the metastatic cascade in various tumors. C-C chemokine receptor 7 (CCR7) interacts with its ligand, (C-C motif) ligand 19 (CCL19), promote EMT. However, association between EMT and CCR7 extrahepatic cholangiocarcinoma (EHCC) remains unknown. This study aimed elucidate prognostic impact of expression clinicopathological features EHCC. status was examined via immunohistochemical staining tumor sections from 181 patients perihilar...
Previous studies on the accuracy of 5-aminolevulinic-acid-mediated photodynamic diagnosis (5-ALA PDD) have been reported for various cancers and brain surgery. However, biliary tract cancer is rare. Therefore, 5-ALA PDD has not fully evaluated in cancers. Small lesions such as peritoneal dissemination, liver metastases, lymph node metastases are negative prognosticators patients with cancer. The purpose this exploratory study was to determine if could detect small murine models...
Objective: IgG4-related sclerosing cholecystitis is generally associated with cholangitis and presents diffuse, circumferential thickening of the gallbladder wall. We report a rare case localized without cholangitis, which was difficult to differentiate from cancer preoperatively. Patient: A 56-year-old man suspected disease or admitted our ward. The serum IgG4 level elevated at 721 mg/dL. Computed tomography (CT) demonstrated focal wall fundus. Drip infusion cholecystocholangiography CT...
Abstract Background Pancreatic ductal carcinoma (PDAC) is an extremely poor prognostic disease. Even though multidisciplinary treatment for PDAC has developed, supportive therapies, such as nutritional therapy or perioperative rehabilitation to sustain and complete aggressive treatment, have not yet been well-established in PDAC. The aim of this study was elucidate the relationship between combined index using psoas muscle mass (PMI) values controlling status (CONUT) score prognosis. Methods...
Primary malignant melanoma of the esophagus (PMME) is a rare disease with poor prognosis. There are few reports early-stage cases in which tumor invasion reached lamina propria or muscularis mucosae, as present case. A standard treatment for PMME has not yet been established. The study aimed to summarize previous and discuss indications surgical primary esophagus. 70-year-old woman was referred our hospital. She underwent thoracoscopic laparoscopic subtotal esophagectomy lymphadenectomy....
Pancreatoduodenectomy with resection of the portal vein or superior mesenteric confluence has been safely performed in patients pancreatic head cancer associated infiltration vein. In recent years, left-sided hypertension, a late postoperative complication, received focus owing to increased long-term survival advances chemotherapy. Left-sided hypertension may sometimes cause fatal gastrointestinal bleeding because rupture varices. Here, we present case colonic varices caused by after...
Chromosome 16 open reading frame 74 (C16orf74) is highly expressed in pancreatic ductal adenocarcinoma (PDAC) and involved cancer cell proliferation invasion through binding to calcineurin (CN). Therefore, C16orf74 a good target for the development of PDAC treatment. A cell-permeable dominant-negative (DN) peptide that can inhibit C16orf74/CN interaction was designed examine whether this vitro vivo.TheDN-C16orf74 peptide, which corresponds portion interacts with CN, synthesized, we assessed...
症例は75歳，女性．早朝，排便時に肛門からの脱出感を自覚し近医を受診したところ，子宮脱と肛門から小腸脱出を認めたため，当科外来へ緊急搬送となった．診察上，子宮脱と肛門から小腸が1m以上にわたり脱出していた．子宮は容易に還納できたが，脱出した小腸は絞扼され暗赤色調であり，還納を試みるも激しい疼痛により不可能であった．直腸穿孔による小腸脱出を疑い緊急手術を施行した．術中所見は直腸前壁に約8cmの縦走裂孔を認め，その穿孔部を通じて回腸が経肛門的に脱出していた．速やかに回腸を還納した後，直腸穿孔部を単純縫合閉鎖した．脱出した回腸にも壊死による穿孔を認めたため縫合閉鎖し，双孔式S状結腸人工肛門を造設して手術を終了した．術後経過は良好で第29病日に退院となった．
Soft coagulation is a hemostatic system of electrosurgical units that automatically regulates its output to avoid carbonization or incision. This widely used in invasive procedures, including thoracic surgery. Few reports exist on the harmful effects these devices. Herein, we encountered case an esophagopleural fistula caused by soft coagulation.
横隔膜交通症は腹膜透析や肝硬変など腹水が貯留する病態に合併するまれな疾患である．症例報告は散見されるが，標準的治療は未だ定まっていない．当科で2018年から2022年の間に経験した7例の横隔膜交通症に対する手術について検討した．男性6例，女性1例，平均年齢は56.4歳であった．原因疾患は慢性腎不全による腹膜透析2例，肝硬変による肝性胸水5例で，全例が右側病変だった．術中横隔膜交通部同定はインジゴカルミンによる色素法またはCO2による気腹法で行い，同定率は57.1％であった．治療は交通部が同定できた症例では交通部の切除または縫縮を行いポリグリコール酸シートとフィブリン糊で補強，同定できなかった症例では同材料で横隔膜全体を被覆した．全例で再発を認めなかった．文献的考察も加え，標準的手術治療について考察する．
BACKGROUND Reversed intestinal malrotation is an extremely rare disease, with incidence of 1 in 250 000. In Japan, application robotic-assisted colorectal cancer surgery expected to increase. There are no reports robot-assisted for cecal reversed malrotation. CASE REPORT An 84-year-old Japanese man epigastric pain and abdominal distention was referred our hospital's Department Gastroenterology thorough examination. Colonoscopy revealed a semicircumferential type 2 tumor the cecum ascending...
Purpose This study aimed to elucidate the relationship between early-stage weight loss (WL) during hospitalization after pancreatic surgery and prognosis investigate risk factors affecting WL. Methods We included 68 patients diagnosed with ductal adenocarcinoma (PDAC) who underwent radical surgery. The %WL value was calculated based on percentage of body at discharge compared admission. High WL defined as >10%. initially evaluated association postoperative survival using Kaplan-Meier method....
症例は76歳，男性．胸部下部食道癌の診断とされ，術前化学療法としてDCF療法を施行後，胸腔鏡腹腔鏡下胸部食道亜全摘術を施行した．再建は胸骨後経路頸部食道胃管再建を行った．術後反回神経麻痺を認めず，嚥下に問題もないため，術後7日目に経口摂取を開始した．術後9日目に嘔吐し，胸部X線上，胃管の拡張を認めた．経鼻胃管を挿入し症状は改善したが，経鼻胃管抜去により胃管拡張が再発した．CT上，胃管の捻じれはなく，たわみによる胃管の屈曲と診断した．一時的にself-expandable metallic stent （SEMS）を留置し，症状は改善し経口摂取可能となった．その後，頸部食道胃管吻合部狭窄を認め，内視鏡的拡張術を施行．狭窄が改善した後，ステント留置41日目にステント抜去した．ステント抜去後も胃管拡張なく経過．術後14カ月，胃管拡張，食道癌の再発なく経過している．
Abstract Pancreatic cancer is one of malignant diseases with poor prognosis. Despite the recent progress for preoperative neoadjuvant chemoradiotherapy, long term prognosis still to make forward new treatment strategy. We have recently reported novel mechanism anticancer reagents impact patients' improving tumor microenvironment other than its direct cytotoxic effects (Ann Surg Oncol 2013, Cancer Sci 2014). The underlying include inhibition HLA class I down regulation and Treg infiltration,...
特発性食道破裂は食道内圧の上昇により食道壁が全層で破裂する疾患で,時間とともに重症化し致命的となる.早急な治療が必要であり,これまで開胸手術が外科治療の中心であったが,近年は鏡視下手術の報告が増えている.当院では2013年12月から2018年10月に特発性食道破裂に対する腹腔鏡手術を5例経験したため,その有用性について検討した.穿孔部位は胸部下部食道左側が1例,腹部食道左側が4例で,全例で穿孔部の縫合閉鎖と胃穹窿部による被覆が行われた.手術時間は中央値で190分,出血量は10 mlであった.合併症は2例に胸水貯留と1例に肺炎を認めたが,縫合不全は認めなかった.死亡例はなかった.腹腔鏡手術は緊急手術としても許容しうる手術時間で,より低侵襲かつ確実な穿孔部の処置が可能であり,胸部下部および腹部食道における特発性食道破裂において有用な術式となりうることが示唆された.