A5102985421- Hormonal Regulation and Hypertension
- Estrogen and related hormone effects
- HIV, Drug Use, Sexual Risk
- Hypothalamic control of reproductive hormones
- Stress Responses and Cortisol
- Eicosanoids and Hypertension Pharmacology
- Peroxisome Proliferator-Activated Receptors
- Retinoids in leukemia and cellular processes
- Chronic Kidney Disease and Diabetes
- Nuclear Receptors and Signaling
- Neuroendocrine regulation and behavior
- Epigenetics and DNA Methylation
- Adrenal and Paraganglionic Tumors
- Various Chemistry Research Topics
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Acute Kidney Injury Research
- Renal and Vascular Pathologies
- Birth, Development, and Health
- 3D Printing in Biomedical Research
- Advanced optical system design
- Adrenal Hormones and Disorders
- Periodontal Regeneration and Treatments
- Pediatric Urology and Nephrology Studies
- Mesenchymal stem cell research
- Vasculitis and related conditions
The University of Kitakyushu
2023-2025
Kyoto Prefectural University of Medicine
2012-2024
Chuo University
2024
Niigata University
2014-2024
National Institutes of Health
2020
Yale University
2020
Harvard University
2020
Rockefeller University
2020
Brigham and Women's Hospital
2020
Cornell University
2020
Epigenetic histone modifications are emerging as important mechanisms for conveyance of and maintenance effects the hormonal milieu to developing brain. We hypothesized that alteration acetylation status early in development by sex steroid hormones is sexual differentiation It was found during critical period differentiation, histones associated with promoters essential genes masculinization brain (estrogen receptor α aromatase) medial preoptic area, an area necessary male behavior, were...
Adult mesenchymal stem cells secrete a variety of angiogenic cytokines and growth factors, so we proposed that these paracrine mechanisms may be used to promote vascularization for tissue engineering in vivo. We tested whether or not human adipose-derived (ASCs) formation rats. ASCs were evaluated vitro mRNA expression including the vascular endothelial factor, basic fibroblast interleukin-8 (IL-8), stromal cell-derived factor-1 (SDF-1) proliferative activity on microvascular cells. For vivo...
Oxidative stress has been suggested as a mechanism underlying skin aging, it triggers apoptosis in various cell types, including fibroblasts, which play important roles the preservation of healthy, youthful skin. Catechins, are antioxidants contained green tea, exert actions such anti-inflammatory, anti-bacterial, and anti-cancer actions. In this study, we investigated effect (+)-catechin on induced by oxidative fibroblasts. Fibroblasts (NIH3T3) under hydrogen peroxide (0.1 mM) were treated...
Gastrin-releasing peptide (GRP) has recently been identified as an itch-specific neuropeptide in the spinal sensory system mice, but there are no reports of expression and distribution GRP trigeminal mammals. We characterized compared GRP-immunoreactive (ir) neurons ganglion (TG) with those rat dorsal root (DRG). immunoreactivity was expressed 12% TG 6% DRG restricted to small- medium-sized type cells. In both DRG, many GRP-ir also substance P calcitonin gene-related peptide, not isolectin...
Peroxisome proliferator-activated receptor-γ (PPARγ) is a nuclear receptor for the antidiabetic agent thiazolidinedione, which exerts various physiological activities, independent of lowering blood glucose. However, role PPARγ in aldosterone production has not been clarified. The objective this study was to investigate effect on synthase gene (CYP11B2) expression and production. Localization normal adrenal cortex determined by immunohistochemistry. Aldosterone CYP11B2 levels were using human...
Abstract Estrogen exerts neuroprotective and promyelinating actions. The therapeutic effect has been shown in animal models of multiple sclerosis, which the myelin sheath is specifically destroyed central nervous system. However, it remains unproven whether estrogen directly involved remyelination via producing cells, oligodendrocytes, or receptors are involved. In this study, we found that membrane‐associated receptor, G protein‐coupled receptor 30 (GPR30), also known as GPER, was expressed...
Estrogen-related receptor (ERR) is a member of the nuclear superfamily that has strong homology with estrogen (ER) α. ERR three subtypes (α, β, and γ) expressed in estrogen-sensitive organs, including ovary, breast, brain. No endogenous ligands ERRs have been identified, but these receptors share common DNA element ERα control estrogen-mediated gene transcription. Recent evidence suggests role estrogen-related pathophysiology, detailed mechanisms functions tissues are unclear. Using...
Fluctuations in olfactory sensitivity are widely known to occur during pregnancy and may be responsible for hyperemesis gravidarum. These changes thought caused by structural functional alterations neurons response marked of the hormonal milieu. In this study, we examined cortex after delivery rats. Dendritic spine densities were measured piriform (PIR) posterolateral cortical amygdala (COApl), which involved olfaction. The results showed increased numbers dendritic spines PIR mid-pregnancy...
The "Summary of Japanese clinical practice guidelines for Bell's palsy (idiopathic facial palsy) - 2023 update edited by the Japan Society Facial Nerve Research" aims to review latest evidence regarding treatment and provide appropriate recommendations.
We have previously established a chamber model of tissue engineering that promotes de novo angiogenesis and vascularization engrafted cells tissues when combined with an extracellular matrix. Here we demonstrate the mouse (MC) can sustain ectopic grafts murine fetal thymus lobes and, to limited degree, human pediatric tissue, resulting in T-cell production. Silicone chambers containing Matrigel((R)) were placed around exposed epigastric vessels ends sealed bone wax, before implantation into...
ABSTRACT ATRA and a synthetic RAR agonist tamibarotene (Am80) induce granulocytic differentiation of human acute leukemia HL-60 cells have been used in antineoplastic therapy. induces CD38 antigen during cell differentiation, which interacts with CD31 on the vascular EC surface may disadvantages We here examined mechanisms ATRA-mediated induction compared difference between ATRA- tamibarotene-mediated induction. Tamibarotene-induced adhesion to ECs was 38% lower than ATRA, NB4 by equivalent...
There is accumulating evidence that fibroblasts are target cells for steroids such as sex hormones and corticoids. The characteristics of vary among tissues organs. Our aim in this study to examine differences responses steroid from different cervicothoracic regions. We compared the actions on cultured vocal folds, which considered be primary hormones, trachea esophagus adult male rats. Expression hormone receptors (androgen receptor, estrogen receptor α, glucocorticoid receptor) was...
Significance Many women exhibit a dramatic increase in itch during pregnancy, but the underlying mechanism is unknown. Here, we demonstrate that female sex steroid hormone estradiol, not progesterone, enhances itch-related scratching behavior rats elicited by histamine, prototypical mediator humans. This associated with an enhancement histamine-evoked activity of subset spinal dorsal horn neurons express neuropeptide receptor, gastrin-releasing peptide receptor (GRPR), was previously shown...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTα-Fluorostyrene: Preparation, Properties, and PolymerizationKen Matsuda, John A. Sedlak, James S. Noland, George C. GlecklerCite this: J. Org. Chem. 1962, 27, 11, 4015–4020Publication Date (Print):November 1, 1962Publication History Published online1 May 2002Published inissue 1 November 1962https://pubs.acs.org/doi/10.1021/jo01058a062https://doi.org/10.1021/jo01058a062research-articleACS PublicationsRequest reuse permissionsArticle...
Antineutrophil cytoplasmic antibody-associated vasculitis is triggered by environmental factors, including silica dust exposure. Repeated tsunami waves brought a large volume of silica-containing sludge inland after the Great East Japan earthquake in 2011. We aimed to determine if serious disaster influenced clinical features microscopic polyangiitis.This an observational retrospective study conducted single institute. A total 43 patients were included based on CHCC2012 criteria for...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and Reactions of 1-Cyanoformimidic Acid HydrazideKEN MATSUDA LUCILLE T. MORINCite this: J. Org. Chem. 1961, 26, 10, 3783–3787Publication Date (Print):October 1, 1961Publication History Published online1 May 2002Published inissue 1 October 1961https://pubs.acs.org/doi/10.1021/jo01068a038https://doi.org/10.1021/jo01068a038research-articleACS PublicationsRequest reuse permissionsArticle Views439Altmetric-Citations21LEARN ABOUT THESE...