A5101964771- Head and Neck Cancer Studies
- Endometrial and Cervical Cancer Treatments
- Brain Metastases and Treatment
- Advanced Radiotherapy Techniques
- Glioma Diagnosis and Treatment
- Management of metastatic bone disease
- Ovarian cancer diagnosis and treatment
- Head and Neck Surgical Oncology
- Meningioma and schwannoma management
- Colorectal and Anal Carcinomas
- Cervical Cancer and HPV Research
- Cancer Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Uterine Myomas and Treatments
- Lymphoma Diagnosis and Treatment
- Vascular Malformations Diagnosis and Treatment
- Lung Cancer Research Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Endometriosis Research and Treatment
- Prostate Cancer Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Ear and Head Tumors
- Angiogenesis and VEGF in Cancer
- Hepatocellular Carcinoma Treatment and Prognosis
UPMC Hillman Cancer Center
2015-2024
West Virginia University
2011-2023
University of Pittsburgh Medical Center
2011-2023
University of Pittsburgh
2012-2023
Magee-Womens Hospital
2015-2023
University of Illinois Chicago
2023
UPMC Health System
2020-2021
Neurological Surgery
2018-2020
Memorial Hospital
2017-2018
West Virginia University Hospitals
2018
<h3>Importance</h3> Although stereotactic radiosurgery (SRS) is preferred for limited brain metastases from most histologies, whole-brain radiotherapy (WBRT) has remained the standard of care patients with small cell lung cancer. Data on SRS are limited. <h3>Objective</h3> To characterize and compare first-line outcomes (without prior WBRT or prophylactic cranial irradiation) those WBRT. <h3>Design, Setting, Participants</h3> FIRE-SCLC (First-line Radiosurgery Small-Cell Lung Cancer) was a...
BACKGROUND: Postoperative stereotactic radiosurgery for brain metastases potentially offers similar local control rates and fewer long-term neurocognitive sequelae compared to whole radiation therapy, although patients remain at risk distant failure (DBF). OBJECTIVE: To describe clinical outcomes of adjuvant large identify predictors intracranial their implications on optimal patient selection criteria. METHODS: We performed a retrospective review 100 (>3 cm) in 99 managed by resection...
Introduction Oncoplastic breast conserving surgery (OBCS) can offer oncologically safe and cosmetically satisfying results for patients with cancer. However, the relative oncologic safety of high tumor-volume oncoplastic resections is largely unknown. This study investigated association between tumor-to-breast volume ratio, recurrence, surgical complications in OBCS. The relationship ratio quality life was also assessed. Methods A retrospective review performed all women who underwent OBCS...
Stereotactic body radiotherapy (SBRT) has been studied in locally recurrent previously-irradiated head and neck cancers; however, the optimum fractionation patient selection continues to be defined.Patients (n = 132) with cancer salvaged via SBRT ± cetuximab (median, 44 Gy/5 fractions) from November 2004 May 2011 were retrospectively reviewed. Disease outcomes toxicity analyzed by predictive factors including treatment duration tumor volume.At a median 6-month follow-up (range, 0-55 months),...
This retrospective study aims to assess the usefulness of SUVmax from FDG-PET imaging as a prognosticator for primary biopsy-proven stage I NSCLC treated with SBRT. includes 95 patients median age 77 years, primary, biopsy-confirmed peripheral IA/IB NSCLC. All were 60Gy in 3 fractions treatment time six days. Local, regional, and distant failures evaluated independently according terms RTOG1021. control, overall- progression-free survival estimated by Kaplan-Meier method. Cox proportional...
Aim: To provide a multi-institutional description of current practices stereotactic body radiotherapy (SBRT) for head and neck cancer. Materials & methods: 15 international institutions with significant experience in SBRT were asked to complete questionnaire covering clinical technical factors. Results: is used 10–100% the time recurrent primary cancer, 0–10% newly diagnosed disease. Five centers use constraint disease 3–5 cm 25–30 cc. Nine apply target volume expansion 1–10 mm 14 planning...
Abstract Background Stereotactic body radiotherapy (SBRT) has emerged as a promising salvage strategy for patients with recurrent, previously irradiated head and neck cancer; however, data are limited predominantly to squamous cell carcinomas. Herein, we report the efficacy of SBRT in nonsquamous cancers (NSCHNs). Methods In all, 34 pathologically proven NSCHN were reirradiated median dose 40 Gy 5 fractions (interquartile range, 30–44 Gy). Toxicity quality life followed prospectively....
Locoregional recurrence remains the primary failure pattern following salvage surgery for previously irradiated head and neck cancer; randomized trials have suggested a complimentary role adjuvant chemotherapy conventional reirradiation at expense of significant increases in toxicity. We aimed to identify if stereotactic body radiotherapy (SBRT) ± cetuximab improves tumor control while reducing treatment-related toxicity surgery.Retrospective review (2005-2011) 28 patients with high-risk...
Mammary angiosarcoma (AS) is an aggressive malignancy with high recurrence rates and poor overall survival. Limited data exist to guide treatment. We aimed identify patterns of failure in the context adjuvant radiation prognostic indicators better management.Thirty-five patients breast AS at UPMC Magee Women's Hospital from June 1994 March 2011 were retrospectively reviewed. Pathology was rereviewed for 22 by expert pathologist using objective scoring system, partly based on Rosen grading...