A5023973397- Advanced Radiotherapy Techniques
- Head and Neck Cancer Studies
- Prostate Cancer Diagnosis and Treatment
- Radiation Therapy and Dosimetry
- Brain Metastases and Treatment
- Lung Cancer Diagnosis and Treatment
- Management of metastatic bone disease
- Glioma Diagnosis and Treatment
- Oral health in cancer treatment
- Medical Imaging Techniques and Applications
- Advanced X-ray and CT Imaging
- Head and Neck Surgical Oncology
- Effects of Radiation Exposure
- Prostate Cancer Treatment and Research
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Ear and Head Tumors
- Electron Spin Resonance Studies
- Neonatal Respiratory Health Research
- Nitric Oxide and Endothelin Effects
- Meningioma and schwannoma management
- Radiopharmaceutical Chemistry and Applications
- Ovarian cancer diagnosis and treatment
- Vascular Tumors and Angiosarcomas
WinnMed
2019-2025
Mayo Clinic Hospital
2022-2025
Mayo Clinic in Florida
2019-2024
University of Pennsylvania
2019
Mayo Clinic in Arizona
2017-2018
Radiation Oncology Associates
2016-2017
Children's Hospital of Los Angeles
2017
University of California, Los Angeles
2017
VA Greater Los Angeles Healthcare System
2017
Hospital of the University of Pennsylvania
2017
Objectives: Large brain metastases (>3 cm) present a therapeutic dilemma, as the dose delivered by stereotactic radiosurgery (SRS) in single fraction is limited toxicity to adjacent tissues, resulting suboptimal local control. This study assessed efficacy and safety of fractionated SRS for treatment large metastases. Materials Methods: We identified 36 patients with 37 treated SRS. The median was 24 Gy (range, 12 27 Gy) 2 5 fractions volume 15.6 mL 10 82.7 mL). Kaplan-Meier analysis used...
BACKGROUND Existing data supporting the use of proton‐beam therapy (PBT) for limited‐stage small cell lung cancer (LS‐SCLC) are limited to a single 6‐patient case series. This is first prospective study evaluate clinical outcomes and toxicities PBT LS‐SCLC. METHODS prospectively analyzed patients with primary, nonrecurrent LS‐SCLC definitively treated concurrent chemotherapy from 2011 2016. Clinical backup intensity‐modulated radiotherapy (IMRT) plans were generated each patient compared...
To retrospectively investigate empirical relative biological effectiveness (RBE) for mandible osteoradionecrosis (ORN) in head and neck (H&N) cancer patients treated with pencil-beam-scanning proton therapy (PBSPT). We included 1,266 H&N patients, of which, 931 were volumetric-modulated arc (VMAT) 335 PBSPT. Among them, 26 VMAT 9 PBSPT experienced ORN (ORN group), while all others the control group. minimize impact possible imbalance clinical factors between dosimetric comparison these two...
Stereotactic body radiotherapy (SBRT) has been studied in locally recurrent previously-irradiated head and neck cancers; however, the optimum fractionation patient selection continues to be defined.Patients (n = 132) with cancer salvaged via SBRT ± cetuximab (median, 44 Gy/5 fractions) from November 2004 May 2011 were retrospectively reviewed. Disease outcomes toxicity analyzed by predictive factors including treatment duration tumor volume.At a median 6-month follow-up (range, 0-55 months),...
Myxofibrosarcoma (MFS) is reported to have a higher risk of local recurrence (LR) following definitive surgical excision relative other soft tissue sarcomas. We reviewed our clinical experience treating MFS investigate predictors LR.We retrospectively treatment outcomes for patients treated at institution between 1999 and 2015. A total 52 were identified. Median age was 65 years (range, 21 86 y). Site disease was: upper extremity (27%), lower (46%), trunk (15%), pelvic (8%), head neck (4%)....
The NCCN Guidelines for Testicular Cancer provide recommendations the multidisciplinary approach to diagnostic workup, treatment, and follow-up testicular germ cell tumors, including both seminoma nonseminoma. These Insights discuss current treatment supporting clinical data seminomas as presented in Version 2.2025 of Cancer.
Abstract Background Stereotactic body radiotherapy (SBRT) has emerged as a promising salvage strategy for patients with recurrent, previously irradiated head and neck cancer; however, data are limited predominantly to squamous cell carcinomas. Herein, we report the efficacy of SBRT in nonsquamous cancers (NSCHNs). Methods In all, 34 pathologically proven NSCHN were reirradiated median dose 40 Gy 5 fractions (interquartile range, 30–44 Gy). Toxicity quality life followed prospectively....
Abstract Background Inter‐fractional and intra‐fractional positioning motion monitoring based on implanted fiducials through kilovoltage (kV) imaging is a cost‐effective approach to enhance intact prostate radiotherapy treatment accuracy. However, comprehensive studies for three‐dimensional (3D) position extraction the corrective action threshold are lacking. Purpose To develop verify fiducial system with 3D information triggered kV images taken during delivery, comprehensively evaluate...
<i>Purpose:</i> The aim of this study was to analyze results stereotactic radiosurgery (SRS) as adjuvant therapy for resected brain metastases. <i>Methods:</i> Medical records patients treated at a single institution with SRS the postoperative cavity metastases were retrospectively reviewed. Patients who completed prescribed regimen following gross-total resection and had no previous whole radiotherapy included in study. Kaplan-Meier analyses used estimate local (LC)...
Both dose and linear energy transfer (LET) could play a substantial role in adverse event (AE) initialization of cancer patients treated with pencil-beam-scanning (PBS) proton therapy. However, not all the voxels within AE regions are directly induced from LET effect. It is important to study synergistic effect by only including subset that dosimetrically important.To perform exploratory investigation effects upon PBS using seed spots analysis.A total 113 head-and-neck (H&N) receiving...
The effect of deletion the nitric oxide synthase 1 gene (NOS1−/−) on radiosensitivity was determined. In vitro, long-term cultures bone marrow stromal cells derived from NOS1−/− were more radioresistant than C57BL/6NHsd (wild-type), NOS2−/− or NOS3−/− mice. Mice each strain received 20 Gy thoracic irradiation 9.5 total-body (TBI), and mice sensitive to both. To determine etiology radiosensitivity, studies histopathology, lower esophageal contractility, gastrointestinal transit, blood counts,...
Management of recurrent presacral rectal cancer is often not amenable to curative surgery. The goal this study evaluate the safety and efficacy cyberknife stereotactic body radiotherapy (SBRT) in management recurrences.Between April 2003 October 2008, 14 patients with tumors from adenocarcinoma were SBRT treated. Eleven treated 36 Gy 3 fractions single fraction 12, 16 or 18 Gy. Tumor response was assessed using evaluation criteria solid tumor (RECIST) criteria. Toxicities common terminology...
Background: The purpose of this study was to compare dosimetric differences related target volume and organs-at-risk (OAR) using 3D-conformal radiotherapy (3DCRT), volumetric modulated arc therapy (VMAT), TomoTherapy (Tomo), proton (PRT), carbon ion (CIRT) as part postoperative thymoma irradiation.Material methods: This single-institutional analysis included 10 consecutive patients treated with adjuvant between December 2013 September 2016. CT-datasets respective RT-structures were...
Abstract Purpose To assess the practicality of employing a commercial knowledge‐based planning tool (RapidPlan) to generate adapted intact prostate and bed volumetric modulated arc therapy (VMAT) plans on iterative cone‐beam computed tomography (iCBCT) datasets. Methods materials Intact RapidPlan models were trained utilizing data from 50 44 clinical cases, respectively. ensure that refined capable producing adequate with single optimization, tested CT datasets by comparing dose‐volume...
Abstract Background Stereotactic body radiation therapy (SBRT) has seen increasing use as a salvage strategy for selected patients with recurrent, previously-irradiated squamous cell carcinoma of the head and neck (rSCCHN). PET-CT may be advantageous tumor delineation evaluation treatment failures in SBRT. We analyzed patterns failure following SBRT rSCCHN assessed impact planning on these failure. Methods retrospectively reviewed 96 treated Seven (7%) were after surgical resection 89 (93%)...