A5052948620- Advanced Radiotherapy Techniques
- Head and Neck Cancer Studies
- Lung Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Treatments and Mutations
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Brain Metastases and Treatment
- 3D Printing in Biomedical Research
- Colorectal and Anal Carcinomas
- Glioma Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Head and Neck Surgical Oncology
- Medical Imaging Techniques and Applications
- Chemotherapy-induced cardiotoxicity and mitigation
- Radiomics and Machine Learning in Medical Imaging
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Surgical Treatments
- Management of metastatic bone disease
- Autophagy in Disease and Therapy
- Global Cancer Incidence and Screening
University of Cincinnati
2021-2025
University of Cincinnati Medical Center
2023-2024
Sabin Vaccine Institute
2024
Los Angeles Mission College
2023
University of North Carolina Hospitals
2016-2021
University of North Carolina at Chapel Hill
2013-2021
Villanova University
2021
The University of Queensland
2019
Texas State University
2018
UNC Lineberger Comprehensive Cancer Center
2017-2018
Purpose The significance of radiotherapy (RT) -associated cardiac injury for stage III non-small-cell lung cancer (NSCLC) is unclear, but higher heart doses were associated with worse overall survival in the Radiation Therapy Oncology Group (RTOG) 0617 study. We assessed impact dose patients treated at our institution on several prospective dose-escalation trials. Patients and Methods From 1996 to 2009, 127 NSCLC (Eastern Cooperative performance status, 0 1) received dose-escalated RT 70 90...
BACKGROUND Stereotactic body radiotherapy (SBRT) is the standard of care for patients with nonoperative, early‐stage non–small cell lung cancer (NSCLC) measuring < 5 cm, but its use among tumors ≥5 cm considerably less defined, existing literature limited to small, single‐institution reports. The current multi‐institutional study reported outcomes evaluating largest such population date. METHODS Clinical/treatment characteristics, outcomes, toxicities, and patterns failure were assessed...
The 5-year overall survival of pancreas adenocarcinoma (PCa) remains less than 10%. Clinical and tumor genomic characteristics have not differentiated PCa long-term survivors (LTSs) from unselected patients. Preclinical studies using fecal transplant experiments LTSs revealed delayed growth through unknown mechanisms involving the microbiota. However, features microbiome in patients with are well described.In this cross-sectional study, comprehensive shotgun metagenomics was performed on...
Abstract Purpose: We aimed to examine the effects of multivalent binding and biomimetic cell rolling on sensitivity specificity circulating tumor (CTC) capture. also investigated clinical significance CTCs their kinetic profiles in patients with cancer undergoing radiotherapy treatment. Experimental Design: Patients histologically confirmed primary carcinoma radiotherapy, or without chemotherapy, were eligible for enrollment. Peripheral blood was collected prospectively at up five time...
564 Background: A variety of local therapy options exist to treat Hepatocellular Carcinoma (HCC) including external radiotherapy (EBRT). Prior yttrium-90 (Y90) delivered transarterially is often a contraindication EBRT in clinical trials and guidelines due concerns cumulative hepatotoxicity, though data suggest higher rates hepatotoxicity limited. This study examines profiles after with without prior Y90 treatment using the ALBI grading system. Methods: Patients treated for HCC from 2016...
Telomeres are composed of simple tandem DNA repeats that protect the ends linear chromosomes from replicative erosion or inappropriate damage response mechanisms. The mammalian Protection Of (POT1) protein interacts with single-stranded telomeric and can exert positive negative effects on telomere length. four distinct POT1 homologs in roundworm Caenorhabditis elegans, deficiency for POT-1 POT-2 resulted progressive elongation occurred because both proteins negatively regulate telomerase. We...
Computed tomography (CT), combined positron emitted and CT (PET/CT), magnetic resonance imaging (MRI) are commonly used in head neck radiation planning. Hybrid PET/MRI has garnered attention for potential added value cancer staging treatment Herein, we compare vs. planning gross tumor volume (GTV) delineation.We prospectively enrolled patients with treated definitive chemoradiation to 60-70 Gy using IMRT. We performed pretreatment contrast-enhanced gadolinium-enhanced PET/MRI. Primary nodal...
Whole-brain radiation therapy (WBRT) delivers a substantial dose to the parotid glands, but glands are not delineated for avoidance and xerostomia has never been reported as an adverse effect. Minimizing toxic effects in patients receiving palliative treatments, such WBRT, is crucial.To assess whether effect of WBRT.This observational cohort study enrolled from November 2, 2015, March 20, 2018, at 1 academic center (University North Carolina Hospitals) 2 affiliated community hospitals (High...
Background & Aims: Early-stage HCC can be treated with thermal ablation or stereotactic body radiation therapy (SBRT). We retrospectively compared local progression, mortality, and toxicity among patients SBRT in a multicenter, US cohort. Approach Results: included adult treatment-naïve lesions without vascular invasion per individual physician institutional preference from January 2012 to December 2018. Outcomes progression after 3-month landmark period assessed at the lesion level...
Abstract Background Stereotactic body radiation therapy (SBRT) has seen increasing use as a salvage strategy for selected patients with recurrent, previously-irradiated squamous cell carcinoma of the head and neck (rSCCHN). PET-CT may be advantageous tumor delineation evaluation treatment failures in SBRT. We analyzed patterns failure following SBRT rSCCHN assessed impact planning on these failure. Methods retrospectively reviewed 96 treated Seven (7%) were after surgical resection 89 (93%)...