A5079220910- Pancreatic and Hepatic Oncology Research
- Metabolism, Diabetes, and Cancer
- Lung Cancer Treatments and Mutations
- Chemotherapy-induced cardiotoxicity and mitigation
- Melanoma and MAPK Pathways
- Lung Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Pancreatic function and diabetes
- Colorectal Cancer Treatments and Studies
- Microtubule and mitosis dynamics
- Dermatological diseases and infestations
- Brain Metastases and Treatment
- Cancer Treatment and Pharmacology
- Dermatology and Skin Diseases
- Cutaneous Melanoma Detection and Management
- Myasthenia Gravis and Thymoma
- Head and Neck Anomalies
- CAR-T cell therapy research
- Cancer Mechanisms and Therapy
- Psoriasis: Treatment and Pathogenesis
- Radiopharmaceutical Chemistry and Applications
- Cancer Genomics and Diagnostics
- FOXO transcription factor regulation
- Autoimmune Bullous Skin Diseases
- Mathematical Biology Tumor Growth
University of North Carolina at Chapel Hill
2016-2024
University Dermatology
2022
UNC Lineberger Comprehensive Cancer Center
2016-2020
Segeberger Kliniken
2020
University of North Carolina Hospitals
2017
University of California, San Francisco
2017
Duke University Hospital
2017
Elekta (Switzerland)
2017
Morpho (United States)
2017
Accuray (United States)
2017
Purpose The significance of radiotherapy (RT) -associated cardiac injury for stage III non-small-cell lung cancer (NSCLC) is unclear, but higher heart doses were associated with worse overall survival in the Radiation Therapy Oncology Group (RTOG) 0617 study. We assessed impact dose patients treated at our institution on several prospective dose-escalation trials. Patients and Methods From 1996 to 2009, 127 NSCLC (Eastern Cooperative performance status, 0 1) received dose-escalated RT 70 90...
Over 55,000 people in the United States are diagnosed with pancreatic ductal adenocarcinoma (PDAC) yearly, and fewer than 20% of these patients survive a year beyond diagnosis. Chemotherapies considered or used nearly every PDAC case, but there is limited understanding complex signaling responses underlying resistance to common treatments. Here, we take an unbiased approach study protein kinase network changes following chemotherapies patient-derived xenograft (PDX) models facilitate design...
There is currently tremendous interest in developing anti-cancer therapeutics targeting cell signaling pathways important for both cancer metabolism and growth. Several epidemiological studies have shown that diabetic patients taking metformin a decreased incidence of pancreatic cancer. This has prompted efforts to evaluate metformin, drug with negligible toxicity, as therapeutic modality Preclinical line xenografts one study patient-derived xenograft (PDX) models were promising, while...
Numerous aspects of cellular signaling are regulated by the kinome-the network over 500 protein kinases that guides and modulates information transfer throughout cell. The key role played both individual assemblies organized into functional subnetworks leads to kinome dysregulation driving many diseases, particularly cancer. In case pancreatic ductal adenocarcinoma (PDAC), a variety associated pathways have been identified for their in establishment disease as well its progression. However,...
ABSTRACT Numerous aspects of cellular signaling are regulated by the kinome – network over 500 protein kinases that guides and modulates information transfer throughout cell. The key role played both individual assemblies organized into functional subnetworks leads to dysregulation being a driver many diseases, particularly cancer. In case pancreatic ductal adenocarcinoma (PDAC), variety associated pathways have been identified for their in establishment disease as well its progression....
Abstract not available.