A5037451541- Colorectal and Anal Carcinomas
- Advances in Oncology and Radiotherapy
- Radiation Dose and Imaging
- Advanced Radiotherapy Techniques
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Treatments and Studies
- Radiation Therapy and Dosimetry
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Renal cell carcinoma treatment
- Lung Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Head and Neck Cancer Studies
- Diversity and Career in Medicine
- Cancer Treatment and Pharmacology
- Cancer Genomics and Diagnostics
- Childhood Cancer Survivors' Quality of Life
- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Radiology practices and education
- Colorectal Cancer Surgical Treatments
- Biomedical Research and Pathophysiology
- Conferences and Exhibitions Management
- Palliative Care and End-of-Life Issues
- Erythrocyte Function and Pathophysiology
University of Cincinnati
2020-2025
University of Cincinnati Medical Center
2020-2025
Texas Tech University
2023
Texas Tech University Health Sciences Center
2023
Digital Health Cooperative Research Centre
2022
Digital China Health (China)
2022
University of Louisville
2015-2020
Rice Institute
2016
Centre College
2014
Plant-based transient overexpression systems enable rapid and scalable production of subunit vaccines. Previously, we have shown that cholera toxin B (CTB), an oral vaccine antigen, is N-glycosylated upon expression in transgenic Nicotiana benthamiana. Here, found aglycosylated CTB by agroinfiltration a tobamoviral vector causes massive tissue necrosis poor accumulation unless retained the endoplasmic reticulum (ER). However, re-introduction N-glycosylation to its original or alternative...
564 Background: A variety of local therapy options exist to treat Hepatocellular Carcinoma (HCC) including external radiotherapy (EBRT). Prior yttrium-90 (Y90) delivered transarterially is often a contraindication EBRT in clinical trials and guidelines due concerns cumulative hepatotoxicity, though data suggest higher rates hepatotoxicity limited. This study examines profiles after with without prior Y90 treatment using the ALBI grading system. Methods: Patients treated for HCC from 2016...
3516 Background: Bevacizumab [Avastin (BV)] is a recombinant, humanized monoclonal antibody directed against vascular endothelial growth factor. As presented at ASCO 2003, the addition of BV to IFL chemotherapy prolonged median survival from 15.61 months 20.34 (p = 0.00004). This was companion trial that studied FU/LV in subjects who were not optimal candidates for first-line irinotecan because age or performance status. Methods: Approximately 200 patients be randomized receive Roswell Park...
Abstract This article considers the concept of designing Phase I clinical trials using both clinician- and patient-reported outcomes to adaptively allocate study participants tolerable doses determine maximum tolerated dose (MTD) at conclusion. We describe an application a Bayesian form continual reassessment method (PRO-CRMB) in ongoing adjuvant hypofractionated whole pelvis radiation therapy (WPRT) endometrial cancer (NCT04458402). The study’s primary objective is MTD per fraction WPRT,...
Triosephosphate isomerase (TPI) deficiency is a rare autosomal recessive disease of infancy and childhood classified as glycolytic enzymopathy. Clinical features include hemolytic anemia, progressive neuromuscular dysfunction, increased susceptibility to infection with specific pathogenic variants resulting in severe death by age 8. Since initially described 1965,1 fewer than 50 clinically affected patients have been the literature. We describe 20-year-old patient variant TPI gene who has...
• Premise of the study: Pterospora andromedea (Ericaceae) is a mycoheterotrophic plant endemic to North America with disjunct distribution. Eastern populations are in decline compared western populations. Microsatellite loci will allow comparison genetic diversity endangered nonthreatened Methods and Results: Illumina MiSeq sequencing resulted development 12 polymorphic microsatellite from 63 perfect tested. One locus was obtained traditional enrichment method. These 13 were screened across...
We hypothesize that hematologic toxicity will be lower in anal cancer patients treated definitively with intensity modulated proton therapy (IMPT) compared radiation (IMRT).Patients enrolled on a prospective feasibility trial assessing the use of IMPT for were contemporaneous IMRT. Blood counts collected during chemoradiation. Hematologic events graded according to CTCAE version 5.0. Pelvic bone marrow (PBM) and positron emission tomography-defined active (ABM) defined contoured each...
The objectives of this study were to evaluate whether dose the vasculature is associated with local control after surgery in patients borderline resectable (BLR) and pancreatic cancer (PCA) receiving neoadjuvant radiation therapy (RT) identify a threshold for clinical use.Patients BLR PCA treated RT retrospectively reviewed. During period, institutional paradigm shifted from standard fractionation hypofractionation/stereotactic body (SBRT). A target volume (Vasc CTV) was contoured each...
The purpose of this trial was to assess the patient and physician-reported toxicity in anal cancer patients undergoing definitive chemoradiation with intensity-modulated proton therapy (IMPT).Patients stage II III were treated IMPT. All received 2 cycles 5-fluorouracil mitomycin concurrently radiation. Toxicity assessed at baseline, weekly during chemoradiation, follow-up using physician-graded common terminology criteria for adverse events (CTCAE) v 4.0 PRO-CTCAE. primary endpoint define...
3564 Background: BV (Avastin) is a monoclonal antibody to VEGF. In the pivotal trial, 813 mCRC patients were randomized IFL+placebo (411) or IFL+BV (402); added first-line IFL significantly prolonged progression-free survival (PFS) and overall (OS). phase II study, FL PFS. Evaluating changes in QOL was secondary objective both studies. Methods: Prespecified endpoints time deterioration (TDQ), measured by Functional Assessment of Cancer Therapy-Colorectal (FACT-C) colon cancer subscale (CCS),...
Sebaceous carcinoma is a rare, aggressive cutaneous malignancy most commonly arising from the periocular area. Extraocular locations of sebaceous carcinomas, particularly outside head and neck region, are rare not well-described. We report case an 89-year-old Caucasian female with right wrist. She initially presented 1.2-centimeter friable nodule on Initial shave biopsy subsequent pathologic evaluation revealed basaloid neoplasm differentiation, atypia, frequent mitoses, consistent...
We hypothesized that there may be a gender disparity in the receipt of Association Residents Radiation Oncology (ARRO) Educator Year Award and sought to elucidate factors contribute differences award receipt.
e24041 Background: Whole pelvis radiation therapy (WPRT) is often used as a definitive or adjuvant treatment in patients with genitourinary, gynecologic, and gastrointestinal (GI) malignancies. Irradiation of nearby bowel can cause acute chronic GI symptoms, which affect patients’ quality life. Radiation has been shown to alter the microbial flora may select for pathogenic species, enhance toxicity. Characteristics fecal metagenome without toxicity unknown. Severity symptoms vary between who...
4161 Background: Improved overall survival (OS) was observed in PREOPANC I after neoadjuvant hypofractionated radiation (HypoFx RT) (36 Gy/15 fractions) and chemotherapy compared with upfront surgery adjuvant localized pancreatic cancer (Pca). Long-course fractionated chemoRT (ConvFracRT) to 50.4 Gy/28 fractions is an alternative regimen which may deliver a biologically higher dose. Potential efficacy differences between HypoFxRT ConvFracRT are not well described. Methods: Efficacy outcomes...
39 Background: Pelvic radiation and myelosuppressive chemotherapy can lead to lymphopenia during the course of preoperative chemoradiation when treating rectal cancer. Lymphopenia has been associated with higher risks recurrence in other cancers, possibly due decreased immunosurveillance. The effect cancer is not well described. We hypothesize that high-grade worse progression-free survival (PFS) overall (OS) patients undergoing chemoradiation. Methods: All treated at our institution...