A5079682715- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- HER2/EGFR in Cancer Research
- Cancer Immunotherapy and Biomarkers
- CRISPR and Genetic Engineering
- Radiomics and Machine Learning in Medical Imaging
- Breast Cancer Treatment Studies
- Genetic factors in colorectal cancer
- PARP inhibition in cancer therapy
- Monoclonal and Polyclonal Antibodies Research
- Ovarian cancer diagnosis and treatment
- Lung Cancer Treatments and Mutations
- Endometrial and Cervical Cancer Treatments
- Cancer Cells and Metastasis
- Molecular Biology Techniques and Applications
- DNA Repair Mechanisms
- Cancer-related Molecular Pathways
- Advanced Biosensing Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Estrogen and related hormone effects
- Hepatocellular Carcinoma Treatment and Prognosis
- Metastasis and carcinoma case studies
- Lung Cancer Research Studies
- Breast Lesions and Carcinomas
- Sarcoma Diagnosis and Treatment
Catholic University of Korea
2015-2025
Seoul St. Mary's Hospital
2019-2025
Beijing University of Posts and Telecommunications
2024
Seoul National University
2019-2022
Incheon St. Mary's Hospital
2014-2018
Inje University Haeundae Paik Hospital
2012-2013
Military Manpower Administration
2009-2011
Uijeongbu St. Mary's Hospital
2009
Growing evidence suggests that the efficacy of immunotherapy in non-small cell lung cancers (NSCLCs) is associated with immune microenvironment within tumor. We aimed to explore radiologic phenotyping using a radiomics approach assess NSCLC. Two independent NSCLC cohorts (training and test sets) were included. Single-sample gene set enrichment analysis was used determine tumor microenvironment, where type 1 helper T (Th1) cells, 2 (Th2) cytotoxic cells targets for prediction computed...
Abstract Targeted next-generation sequencing (NGS) technology detects specific mutations that can provide treatment opportunities for colorectal cancer (CRC) patients. We included 145 CRC patients who underwent surgery. analyzed the mutation frequencies of common actionable genes and their association with clinicopathological characteristics oncologic outcomes using targeted NGS. Approximately 97.9% (142) showed somatic mutations. Frequent were observed in TP53 (70%), APC (60%), KRAS (49%)....
Background Spread through air spaces (STAS) has recently been demonstrated to exhibit a negative impact on lung adenocarcinoma prognosis. However, most of these studies investigated STAS in nonmucinous adenocarcinoma. Here, we the incidence invasive mucinous (IMA) and evaluated whether tumor was risk factor disease recurrence IMA. We also examined clinicoradiologic factors patients with IMA harboring STAS. Methods reviewed pathologic specimens imaging characteristics primary tumors from 132...
Aims Immunohistochemical (IHC) staining of p53 is a potential marker for TP53 mutations in various cancers. However, criteria predicting triple‐negative breast cancer (TNBC) using IHC are not yet established. We aim to correlate expression patterns with mutation status TNBC. Methods and Results A total 113 TNBC cases were analysed pattern somatic whole‐exome sequencing. Functional properties determined the National Cancer Institute (NCI) database. P53 categorized as nuclear overexpression (...
Abstract In our previous study, we developed a triple-negative breast cancer (TNBC) subtype classification that correlated with the TNBC molecular subclassification. this aimed to evaluate predictor variables of on whole slide and validate model’s performance by using an external test set. We explored characteristics investigated genomic alterations, including scar signature scores. First, was classified into luminal androgen receptor (LAR) non-luminal (non-LAR) subtypes based AR Allred...
Insulin-like growth factor 1 receptor (IGF-1R) is commonly expressed in primary breast cancers. Understanding the role of IGF-1R signaling different subtypes cancer important because each subtype has a outcome and requires treatment modalities. However, precise biological significance expression cells still unclear. In this study, we examined molecular cancer. The effects on survival rates outcomes were also examined.
Trichophyton usually causes a superficial skin infection, affecting the outermost layer of epidermis, stratum corneum. In immunocompromised patients, deeper invasion into dermis and even severe systemic infection with distant organ involvement can occur. Most cases dermal dermatophytosis described in literature so far involved pre-existing dermatophytosis. We report 68-year-old woman presented to our clinic 3-month history palpable nodules on right ankle without Magnetic resonance imaging...
We investigated the patterns and timing of recurrence death as well prognostic factors based on clinicopathological radiological in patients who underwent surgical treatment for invasive mucinous adenocarcinoma (IMA).We reviewed findings including spread through air spaces (STAS) CT IMA such morphology, solidity, margin, well-defined heterogeneous ground-glass opacity, angiogram, bronchogram signs from 121 consecutive resection. Prognostic disease-free survival (DFS) overall (OS) were...
Background One of the two copies X chromosome is randomly inactivated in females as a means dosage compensation. Loss inactivation (XCI) observed breast and ovarian cancers, frequent basal-like subtype BRCA1 mutation-associated cancers. We investigated clinical implications loss XCI cancer association between dysfunction. Materials Methods used open source data generated by The Cancer Genome Atlas (TCGA) Data Analysis Centers. Ward's hierarchical clustering method was to classify methylation...
Amelogenesis imperfecta (AI) is a collection of genetic disorders affecting the quality and/or quantity tooth enamel. More than 20 genes are, so far, known to be responsible for this condition. In study, we recruited 3 Turkish families with hypomaturation AI. Whole-exome sequence analyses identified disease-causing mutations in each proband, and these cosegregated AI phenotype all members family. The AI-causing family 1 were novel
Studies correlating specific genetic mutations and treatment response are ongoing to establish an effective strategy for gastric cancer (GC). To facilitate this research, a cost- time-effective method analyze the mutational status is necessary. Deep learning (DL) has been successfully applied hematoxylin eosin (H E)-stained tissue slide images.
Objective Poly(ADP-ribose) polymerase (PARP) inhibitors are used for targeted therapy ovarian cancer with homologous recombination deficiency (HRD). In this study, we aimed to develop a prediction model predict the genomic integrity (GI) index of SOPHiA DDM HRD Solution from Oncomine Comprehensive Assay (OCA) Plus. We also tried find cut-off value instability metric (GIM) OCA Plus that correlates GI Solution. Methods included 87 cases high-grade serous carcinoma five tertiary referral...
Amplification of the human epidermal growth factor receptor 2 (HER2) gene occurs in 18% to 20% breast cancers, and it is recognized as a prognostic predictive marker. We investigated HER2 status Korean cancer by immunohistochemistry (IHC) silver-enhanced situ hybridization (SISH), first step toward building nationwide quality assurance program for testing.A total 1,198 carcinoma samples were collected from six institutions IHC SISH performed using tissue microarrays central laboratories. The...
Accurate molecular classification of breast core needle biopsy (CNB) tissue is important for determining neoadjuvant systemic therapies invasive cancer. The researchers aimed to evaluate the concordance rate (CR) subtypes between CNBs and surgical specimens.This study was conducted with cancer patients who underwent surgery after CNB at Seoul St. Mary's Hospital December 2014 2017. Estrogen receptor (ER), progesterone (PR), human epidermal growth factor 2 (HER2), Ki67 were analyzed using...
We investigated the clinical implications of biallelic loss PTEN in clear cell renal carcinoma and whether would induce p53 dependent cellular senescence.Data were obtained using CGDS-R package from TCGA data set kirc_tcga_pub. allelic status was classified into 3 groups, including (homozygous deletion or combined heterozygous mutation), monoallelic (heterozygous mutation) absent loss. Univariate multivariate overall survival analysis performed. TP53 mean expression genes related to...
Detecting high-risk (HR) HPV is important for clinical management of women with persistent HPV-positive and Pap-negative results. The Cobas 4800 test the first FDA-approved DNA that can be used alone as a first-line screening tool. 9G chip PCR-based microarray assay. We evaluated patients consecutive HPV-positivity on without cytologic abnormalities. then compared performances tests detecting HR each other confirmed genotyping using direct sequencing. All 214 liquid-based cytology specimens...
Triple-negative breast cancer (TNBC) is an aggressive type of cancer. Currently, no effective treatment options for this condition exist. Nuclear factor erythroid 2-related 2 (NRF2), encoded by nuclear erythroid-derived 2-like (NFE2L2) gene and its endogenous inhibitor, Kelch-like ECH-associated protein 1 (KEAP1), both participate in cellular defense mechanisms against oxidative stress contribute to chemoresistance tumor progression numerous types cancers. This study aimed evaluate the...