A5010636992- Cancer, Stress, Anesthesia, and Immune Response
- Gut microbiota and health
- Hematological disorders and diagnostics
- Plasma and Flow Control in Aerodynamics
- Colorectal Cancer Screening and Detection
- Pluripotent Stem Cells Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Boron Compounds in Chemistry
- Medication Adherence and Compliance
- Long-Term Effects of COVID-19
- COVID-19 and Mental Health
- RNA Interference and Gene Delivery
- Computational Fluid Dynamics and Aerodynamics
- Electronic Health Records Systems
- CRISPR and Genetic Engineering
- Mobile Health and mHealth Applications
- Cancer Cells and Metastasis
- Cancer Diagnosis and Treatment
- Gas Dynamics and Kinetic Theory
- Cancer Research and Treatments
Memorial Sloan Kettering Cancer Center
2024-2025
Kettering University
2024
Cornell University
2022-2024
United States Air Force Academy
2023
University of California, Los Angeles
2020
Universidad Católica de Santiago de Guayaquil
2019
As cancers progress, they become increasingly aggressive—metastatic tumours are less responsive to first-line therapies than primary tumours, acquire resistance successive and eventually cause death1,2. Mutations largely conserved between metastatic from the same patients, suggesting that non-genetic phenotypic plasticity has a major role in cancer progression therapy resistance3–5. However, we lack an understanding of cell states mechanisms by which transition. Here, cohort biospecimen...
Monogenic disorders of the blood system have potential to be treated by autologous stem cell transplantation ex vivo genetically modified hematopoietic and progenitor cells (HSPCs). The sgRNA/Cas9 allows for precise modification genome at single nucleotide resolution. However, is reliant on endogenous cellular DNA repair mechanisms mend a Cas9-induced double stranded break (DSB), either non-homologous end joining (NHEJ) pathway or cell-cycle regulated homology-directed (HDR) pathway. Here,...
Abstract Background: The incidence of early onset (EO) colorectal cancer (CRC) (age <50) is rising with a left-sided predominance. Response to chemotherapy and anti-EGFR therapies differ in left- right-sided colon cancers after accounting for genomic differences. intestinal microbiome may contribute CRC pathogenesis response therapy; how organisms drive metastasis treatment resistance not known. Purpose: To define the contribution EO-CRC by analyzing longitudinal samples from...
Villacrs, Camila Quinde; Ochoa G, Sebastian; Schettino, Marissa; Benitez, Elizabeth; Hilbron, Alberto Sanchez; Cuenca, John Author Information