Valeria Sgambati
A5070174389- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Genetic factors in colorectal cancer
- Ferroptosis and cancer prognosis
- Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Boron Compounds in Chemistry
Memorial Sloan Kettering Cancer Center
2023-2025
As cancers progress, they become increasingly aggressive—metastatic tumours are less responsive to first-line therapies than primary tumours, acquire resistance successive and eventually cause death1,2. Mutations largely conserved between metastatic from the same patients, suggesting that non-genetic phenotypic plasticity has a major role in cancer progression therapy resistance3–5. However, we lack an understanding of cell states mechanisms by which transition. Here, cohort biospecimen...
Abstract Inflammation has long been recognized to contribute cancer development, particularly across the gastrointestinal tract. Patients with inflammatory bowel disease have an increased risk for cancers, and it posited that a field of genetic changes may underlie this risk. Here, we define clinical features, genomic landscape, germline alterations in 174 patients colitis-associated cancers sequenced 29 synchronous or isolated dysplasia. TP53 alterations, early highly recurrent event occur...
Metastasis is the principal cause of cancer death, yet we lack an understanding metastatic cell states, their relationship to primary tumor and mechanisms by which they transition. In a cohort biospecimen trios from same-patient normal colon, colorectal cancer, show that while tumors largely adopt LGR5 + intestinal stem-like metastases display progressive plasticity. Loss states accompanied reprogramming into highly conserved fetal progenitor state, followed non-canonical differentiation...