A5081904331- PARP inhibition in cancer therapy
- Ovarian cancer diagnosis and treatment
- Breast Cancer Treatment Studies
- CRISPR and Genetic Engineering
- Cancer Genomics and Diagnostics
- DNA Repair Mechanisms
- Cancer Diagnosis and Treatment
- BRCA gene mutations in cancer
- Pregnancy and preeclampsia studies
- Genetic factors in colorectal cancer
- Gestational Diabetes Research and Management
- Bariatric Surgery and Outcomes
- Surgical Simulation and Training
- Epigenetics and DNA Methylation
- Pancreatic and Hepatic Oncology Research
- Economic and Financial Impacts of Cancer
- Metabolism, Diabetes, and Cancer
- Iron Metabolism and Disorders
- Genetic Syndromes and Imprinting
- HER2/EGFR in Cancer Research
- Anatomy and Medical Technology
- Adrenal Hormones and Disorders
- Ethics in Clinical Research
- Surgical Sutures and Adhesives
- Sex and Gender in Healthcare
University Hospital of Basel
2020-2025
University of Basel
2025
Walter and Eliza Hall Institute of Medical Research
2023-2024
The University of Melbourne
2023-2024
National Cancer Centre Japan
2022
Heidelberg University
2012
University Hospital Leipzig
2000
Epigenetic alterations, including aberrant DNA methylation, are now recognized as bone fide hallmarks of cancer, which can contribute to cancer initiation, progression, therapy responses and resistance. Methylation gene promoters have a range impacts on risk, clinical stratification therapeutic outcomes. We provide several important examples genes, be silenced or activated by promoter methylation highlight their implications. These include the mismatch repair genes MLH1 MSH2, homologous...
In clinical practice, gestational diabetes mellitus (GDM) is treated as a homogenous disease but emerging evidence suggests that the diagnosis of GDM possibly comprises different metabolic entities. this study, we aimed to assess early pregnancy characteristics entities classified according presence fasting and/or post-load hyperglycaemia in diagnostic oral glucose tolerance test performed at mid-gestation.In prospective cohort 1087 pregnant women received broad risk evaluation and...
Background Endocrine therapy is standard of care maintenance treatment for estrogen receptor (ER) positive breast cancers and increasingly used in low-grade serous ovarian cancer. However, its therapeutic role the early setting ER high-grade cancer (HGSC) remains undefined. Methods A retrospective analysis was conducted on clinicopathological data from patients with newly diagnosed HGSC following completion adjuvant chemotherapy. Patients received either or without aromatase inhibitor...
DNA methyltransferase 1 inhibitor (DNMT1i) therapy is a promising option for increasing immune response as part of combination cancer therapy. High–grade serous ovarian carcinoma (HGSOC) highly aggressive with poor survival outcomes, where DNMT1i being increasingly explored. HGSOC epigenetically silenced BRCA1 has been shown to respond PARP (PARPi) treatment – core targeted HGSOC. However, loss silencing even single allele causes PARPi and platinum chemotherapy resistance. We tested whether...
Background: Endocrine therapy is the standard-of-care maintenance treatment for estrogen receptor (ER)-positive breast cancers and increasingly used in low-grade serous ovarian cancer. However, its therapeutic role early setting ER-positive high-grade cancer (HGSC) remains undefined. Methods: A retrospective analysis was conducted on clinicopathological data from patients with newly diagnosed HGSC following completion of adjuvant chemotherapy. Patients received either or without aromatase...
Findings from clinical trials have led to advancement of care for patients with gynecologic malignancies. However, restrictive inclusion into has been widely criticized inadequate representation the real-world population. Ideally, enrolled in should represent a broader population enhance external validity and facilitate translation outcomes across all relevant groups. Specifically, there systematic lack data underrepresented groups, many studies failing report or differentiate study...
Background We aim to evaluate the impact of prepregnancy overweight on treatment modalities Gestational Diabetes Mellitus (GDM). assessed association increased pregravid Body Mass Index (BMI) with dosing basal and rapid acting insulin as well pregnancy outcome. Methods included 509 gestational diabetic women (normal weight: 200, overweight: 157, obese: 152), attending outpatient clinic at Department Obstetrics Gynecology, Medical University Vienna, in this retrospective study. used a...
In ovarian and breast cancer, promoter methylation of
splice isoforms Δ11 and Δ11q can contribute to PARP inhibitor (PARPi) resistance by splicing-out the mutation-containing exon, producing truncated, partially-functional proteins. However, clinical impact underlying drivers of
ObjectiveTying knots during suturing is one of the most challenging tasks in laparoscopic surgery. Therefore, measures aimed at ensuring both ease and speed knot tying not only benefit surgeon but can also reduce operating time significantly. This study compared extracorporeal intracorporeal techniques using a Szabo pelvic trainer model from Gynaecological Endoscopic Surgical Education Assessment program.DesignThe students tied intra- closed- open-jaw pushers. Using an artificial tissue pad...
Insulin-like growth factor 2 (IGF2) is the predominant IGF in adults and regulates cell growth. In contrast to normal tissues, where IGF2 imprinted only expressed from paternal allele, loss of imprinting (LOI) biallelic expression are observed many cancers including prostate cancer (PCa). We here studied whether LOI circulating peripheral blood lymphocytes can predict increased PCa risk.We analyzed protein levels, 820G/A genotype status, as well methylation status control region (ICR) 113...
Contralateral axillary lymph node metastasis (CALNM) in breast cancer (BC) is considered a distant metastasis, marking stage 4cancer. Therefore, it generally treated as an incurable disease. However, clinical practice, staging and treatment remain controversial due to paucity of data, the St. Gallen 2021 consensus panel recommended curative approach patients with oligometastatic Aberrant (LN) drainage following previous surgery or radiotherapy common. CALNM may be regional event rather than...
Pituitary apoplexy is caused by haemorrhage or infarction of the pituitary gland. Presenting signs and symptoms often include severe headache, visual disturbance, ophthalmoplegia, altered consciousness impaired function. The management has very rarely been described during pregnancy there no existing data for further pregnancies affected women. We present a case woman with recurrent due to haemorrhages in adenoma her third fourth pregnancies. In both pregnancies, was managed conservatively,...
<h3>Introduction/Background</h3> Poly-ADP ribose polymerase inhibitors (PARPi) provide impressive therapeutic responses in carcinomas with deficiencies the homologous recombination (HR) DNA repair pathway. After BRCA1/2 mutations, epigenetic silencing of BRCA1 is next most common HR defect high grade serous ovarian (HGSOC), present 7–17% cases. promoter hypermethylation (meBRCA1), when homozygous, silences gene expression and correlates clinical response to PARPi. Loss meBRCA1 after...
Purpose The pregnancy cohort was established to examine the prevalence and variety of haemoglobinopathies in a high-risk group pregnant women. Participants is located Department Obstetrics Antenatal Care, University Hospital Basel. women were recruited first trimester between June 2015 May 2019. Family origin questionnaires used screen for risk haemoglobin variant. Based on questionnaire, divided into two groups: with high low In risk, red blood cell indices, iron status chromatography...
Abstract Purpose Applying current treatment guidelines to elderly breast cancer (BC) patients is challenged by limited trial guidance, higher toxicities, and non-cancer related mortality. This study investigated adherence multidisciplinary team meeting (MDTM) recommendations in women with HER2 positive BC (HER2+BC) its impacts on patient survival. Methods retrospective multicentre cohort collected data from 305 primary diagnosis of HER2+BC. Women aged ≥65 years were classified into...
Abstract Introduction Contralateral axillary lymph node metastasis (CALNM) in breast cancer (BC) is considered a distant metastasis, marking stage IV cancer. Therefore, it generally treated as an incurable disease. However, clinical practice, staging and treatment remain controversial due to paucity of data, the St. Gallen 2021 consensus panel recommended curative approach patients with oligometastatic Aberrant (LN) drainage following previous surgery or radiotherapy common. CALNM may be...
Abstract Background: The gamification of laparoscopy using physical computing is an attempt to incentivize training and generate data for analysis. Here, we evaluate a laparoscopic dexterity game box (LDGB) in pelvitrainer model by comparing the performance validated Laparoscopic Skills Training Testing 3 (LASTT 3) exercise from Gynaecological Endoscopic Surgical Education Assessment (GESEA) program. Methods: Sixty medical students with no experience were randomized into three groups 20...