A5025704138- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Cardiac Health and Mental Health
- Acute Myocardial Infarction Research
- Atherosclerosis and Cardiovascular Diseases
- Peripheral Artery Disease Management
- Lipoproteins and Cardiovascular Health
- Cardiac, Anesthesia and Surgical Outcomes
- Blood Pressure and Hypertension Studies
- Cardiovascular Issues in Pregnancy
- Cell Adhesion Molecules Research
- Atrial Fibrillation Management and Outcomes
- Vascular Procedures and Complications
- Antiplatelet Therapy and Cardiovascular Diseases
- Cerebrovascular and Carotid Artery Diseases
- Healthcare Systems and Public Health
- Cardiac Arrhythmias and Treatments
- Cardiovascular Disease and Adiposity
- Cytokine Signaling Pathways and Interactions
- Neuroinflammation and Neurodegeneration Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Pharmaceutical Economics and Policy
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
National Medical Research Center of Cardiology
2019-2024
Institute of Experimental Cardiology
2016-2017
Background: The extent of myocardial damage largely determines both in-hospital and long-term mortality in patients with acute coronary syndrome. According to the literature, rates unstable angina (UA) are lower than those infarction (MI).
 Aim: To evaluate their predictors undergoing in-patient treatment for syndrome (MI UA) regional cardiovascular center service territory 1 million persons.
 Materials methods: This retrospective registry study enrolled 1130 (715 [63.3%] men, 415...
Immune and inflammatory reactions contribute to the progression of atherosclerosis. The walls different arteries segments have heterogeneous haemodynamic histological features. We aimed explore relationship between circulating T-cell subsets abundance carotid atherosclerosis in arteries.70 patients underwent ultrasound duplex scanning determine degree stenosis common artery (CCA), CCA bifurcation or internal (ICA). blood frequencies T-, B-, NK-cells, regulatory T cells (Treg), activated...
Background. Systems for self-determination of international normalized ratio (INR) may increase adherence to regular monitoring hemostasis parameters in patients taking vitamin K antagonists. However, evidence the effectiveness INR real-world clinical practice Russia is limited. Aim. To compare remote using CoaguChek® INRange coagulometer who have undergone mechanical heart valve implantation with traditional control by measuring it outpatient department laboratory. Materials and methods. A...
Objective. Assess time and possible predictors of restenosis after the implantation first- second-generation coronary stents bare metal (BMSs) in patients with stable artery disease elective stenting. Materials Methods. From 2010 to 2014, 3,732 (2,897 males, 60 [53; 68] years old) exertional angina functional class I–III underwent 2014 2017, 1,487 (1,173 males 314 females) returned. Repeat angiography was performed 699 patients. Results. A total 644 first-generation stents, 5,321 473 BMSs...
Aim To evaluate prescription of lipid-lowering and antithrombotic therapy in clinical practice to compare differences recommendations using the decision support service (CDSS).Material methods Electronic medical records (EMR) 300 patients from Chazov National Medical Research Center Cardiology, as well organizations controlled by Department Health Lipetsk Region Ministry Voronezh Region, were analyzed for period August - December 2022, during pilot implementation CDSS. Retrospective...
Aim . To compare the prevalence of coronary atherosclerosis in patients after stenting (CS) receiving outpatient and remote cardiology follow-up during a one-year study. Material methods We enrolled 279 aged 61,5±9,5 years with class ≥II stable angina or silent ischemia CS. Three groups were formed: group 1 (n=96) — visits before CS, 1, 3, 6 12 months Group 2 (n=95) monitoring: followed up by primary care physician involvement cardiologist via communication (e-mail, telephone, Skype) 3...
Proinflammatory status is the risk factor for coronary atherosclerosis progression after stenting (CS). Intensive statin treatment associated with hsCRP concentration decline.to evaluate prognostic significance of preprocedural level reduction intensive regimen during one year CS.We enrolled 102 patients stable angina who were on list scheduled CS. Group I (n=37) received atorvastatin 80 mg 7 days before and 3 months CS further dose adjustment according to LDL; group II (n=65) 20-40 mg/day...
Every year formed by more than 200 thousand patients who have coronary stenting and need regularly observation. A large number of live in remote areas do not the opportunity to be under regular control cardiologist.
Aim To analyze the relationship between serum concentrations of high-sensitivity C-reactive protein (hsCRP) in dynamics and development restenosis at 12 months following elective coronary stent placement (CSP). Material methods The key role atherogenesis, neointimal proliferation belongs to inflammation. This study included 91 patients (median age, 60 [56; 66] years) with stable exertional angina after an CSP using second-generation stents. Follow-up coronarography was performed for months....
В настоящее время ишемическая болезнь сердца (ИБС) является наиболее частой причиной смерти в развитых странах, причем смертность от хронических ее форм значительно преобладает над смертностью инфаркта миокарда (ИМ). С изменением тактических подходов к лечению ИМ снизилась госпитальная летальность, однако отсроченном периоде остается высокой, достигая, по некоторым данным, 25,1%. настоящем обзоре проанализированы данные об отдаленном прогнозе после данным как российских, так и зарубежных...
Objective: Proinflammatory status is the risk factor for coronary atherosclerosis progression after stenting (CS). Intensive statin treatment associated with high-sensitivity C-reactive protein (hsCRP) concentration decline. We aimed to evaluate prognostic significance of preprocedural hsCRP level reduction intensive regimen during one year CS. Design and method: enrolled 102 patients stable angina who were on list scheduled Group I (n = 37) received atorvastatin 80 mg 7 days before 3 months...
Резюме Атеросклероз — хроническое воспалительное заболевание крупных артерий, в инициации и прогрессии которого активное участие принимают различные субпопуляции Т7лимфоцитов. T7хелперы 1, 17, 9, 22, CD8+ Т7лимфоциты обладают проатерогенными свойствами, поддерживая воспалительную реакцию стенке сосуда. Регуляторные подавляют эффекторную активность вышеупомя7 нутых клеток. Экспериментальные иммунотерапевтические подходы, результате которых модулировались количество и/или функцио7 нальная ряда...
BACKGROUND: Adherence to drug therapy in patients with coronary artery disease is quite low nowadays, both myocardial infarction and chronic forms of disease.
 AIMS: our work was assess adherence (aspirin statins) control risk factors for undergoing stenting 12 months after endovascular treatment.
 MATERIALS AND METHODS: The study included 279 patients, whom 3 groups were formed. Patients group 1 (n=96) personally visited the National Medical Research Center Cardiology Ministry...
Modern pathogenetic therapy of idiopathic pulmonary arterial hypertension (IPAH), a severe life-threatening cardiovascular disease unknown etiology, leads to positive clinical effect due reverse remodeling the vessels microvasculature lungs. Highly effective drugs specific that act on main targets pathogenesis have now been introduced into practice. The presented case patient with diagnosed in 2014 IPAH an initial functional class III according WHO classification demonstrates high long-term...
Aim. Coronary stenting is the evidence-based treatment approach of stable angina. The objective was to determine incidence restenosis or atherosclerosis progression which led need for coronary angiography according a single center registry data. Materials and methods. procedure clinical data 3732 (2897 males) consecutive artery disease patients undergoing stenting, over five years between March 2010 September 2014, were subject this study. Over next 4 years, 1487 (1173 re-evaluated due...