A5079002531- Cancer, Hypoxia, and Metabolism
- Heat shock proteins research
- ATP Synthase and ATPases Research
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Characterization and Applications of Magnetic Nanoparticles
- Eicosanoids and Hypertension Pharmacology
- Cancer Mechanisms and Therapy
- Mechanical stress and fatigue analysis
- Developmental Biology and Gene Regulation
- Connexins and lens biology
- Ubiquitin and proteasome pathways
- Cholesterol and Lipid Metabolism
- Cellular Mechanics and Interactions
- Cancer Cells and Metastasis
- Spaceflight effects on biology
- Immune cells in cancer
- RNA regulation and disease
- Pluripotent Stem Cells Research
- Marine Ecology and Invasive Species
- Myofascial pain diagnosis and treatment
- Metabolism, Diabetes, and Cancer
- Microtubule and mitosis dynamics
- Ion Transport and Channel Regulation
- Chromatin Remodeling and Cancer
Justus-Liebig-Universität Gießen
2011-2023
Technical University of Darmstadt
2017-2023
Pediatrics and Genetics
2020
Faculty (United Kingdom)
2020
University College of Osteopathy
2020
North-Western State Medical University named after I.I. Mechnikov
2020
St Petersburg University
2020
Privolzhsky Research Medical University
2020
Research Centre for Medical Genetics
2018
Friedrich-Alexander-Universität Erlangen-Nürnberg
2011
Hypoxia is a common feature of solid tumors, which controls multiple aspects cancer progression. One important function hypoxia and the hypoxia-inducible factors (HIF) maintenance stem-like cells (CSC), population tumor that possess stem cell-like properties drives growth. Among changes promoted by metabolic shift resulting in acidification microenvironment. Here, we show glioma acidosis functionally cooperate inducing HIF transcription CSC maintenance. We found these effects did not involve...
Abstract Solid tumours are exposed to microenvironmental factors such as hypoxia that normally inhibit cell growth. However, tumour cells capable of counteracting these signals through mechanisms largely unknown. Here we show the prolyl hydroxylase PHD3 restrains growth in response cues control EGFR. silencing human gliomas or genetic deletion a murine high-grade astrocytoma model markedly promotes and ability continue growing under unfavourable conditions. The growth-suppressive function is...
Tumours exploit their hypoxic microenvironment to induce a more aggressive phenotype, while curtailing the growth-inhibitory effects of hypoxia through mechanisms that are poorly understood. The prolyl hydroxylase PHD3 is regulated by and plays an important role in tumour progression. Here we identify as central regulator epidermal growth factor receptor (EGFR) activity control EGFR internalization restrain growth. controls acting scaffolding protein associates with endocytic adaptor Eps15...
Cytosine modifications diversify and structure the genome thereby controlling proper development differentiation. Here, we focus on interplay of 5-methylcytosine reader Mbd1 modifier Tet1 by analyzing their dynamic subcellular localization formation Tet oxidation product 5-hydroxymethylcytosine in mammalian cells. Our results demonstrate that enhances Tet1-mediated oxidation. We show this is due to enhancing Tet1, but not Tet2 Tet3 at heterochromatic DNA. find recruitment concomitantly its...
Glioblastoma multiforme, a highly aggressive tumor of the central nervous system, has dismal prognosis that is due in part to its resistance radio- and chemotherapy. The protein kinase C (PKC) family serine threonine kinases been implicated formation proliferation glioblastoma multiforme. Members D (PKD) family, which consists PKD1, -2 and, -3, are prominent downstream targets PKCs could play major role growth. PKD2 was expressed both low-grade high-grade human gliomas. number PKD2-positive...
Abstract Mutations in genes encoding components of BAF (BRG1/BRM-associated factor) chromatin remodeling complexes cause neurodevelopmental disorders and tumors. The mechanisms leading to the development these two disease entities alone or combination remain unclear. We generated mice with a heterozygous nervous system-specific partial loss-of-function mutation core component gene, Smarcb1 . These mutant show various brain midline abnormalities that are also found individuals Coffin–Siris...
This work examines the effect of changing ratio different surfactants in single-core iron-based nanoparticles with respect to their specific absorption rate context magnetic hyperthermia and cellular uptake by human umbilical vein endothelial cells (HUVEC). Three types were synthesized separately adding oleic acid or oleylamine a mixture both (oleic acid/oleylamine) as surfactants. A carefully controlled thermal decomposition synthesis process led monodispersed narrow size distribution....
The gene product of RSC1A1, RS1, participates in the regulation Na(+)-D-glucose cotransporter SGLT1. RS1 inhibits release SGLT1 from trans Golgi network. In subconfluent LLC-PK(1) cells, migrates into nucleus and modulates transcription SGLT1, whereas most confluent cells do not contain nuclei. We showed that confluence-dependent nuclear location is because different phases cell cycle identified a shuttling domain (RNS) with an associated protein kinase C (PKC) phosphorylation site (RNS-PKC)...
В настоящее время ишемическая болезнь сердца (ИБС) является наиболее частой причиной смерти в развитых странах, причем смертность от хронических ее форм значительно преобладает над смертностью инфаркта миокарда (ИМ). С изменением тактических подходов к лечению ИМ снизилась госпитальная летальность, однако отсроченном периоде остается высокой, достигая, по некоторым данным, 25,1%. настоящем обзоре проанализированы данные об отдаленном прогнозе после данным как российских, так и зарубежных...
На настоящий момент приверженность к медикаментозной терапии у лиц с сердечно-сосудистыми заболеваниями, в частности, после перенесенного инфаркта миокарда (ИМ) является невысокой. Низкая лечению ассоциирована неблагоприятным клиническим прогнозом, включая смерть, повторные госпитализации, острый коронарный синдром (ОКС), острое нарушение мозгового кровообращения (ОНМК), внеплановую коронарную реваскуляризацию. В данном обзоре рассмотрена факторы, ассоциированные высокий и, напротив, низкой...
<div>Abstract<p>Hypoxia is a common feature of solid tumors, which controls multiple aspects cancer progression. One important function hypoxia and the hypoxia-inducible factors (HIF) maintenance stem-like cells (CSC), population tumor that possess stem cell-like properties drives growth. Among changes promoted by metabolic shift resulting in acidification microenvironment. Here, we show glioma acidosis functionally cooperate inducing HIF transcription CSC maintenance. We found...
<div>Abstract<p>Hypoxia is a common feature of solid tumors, which controls multiple aspects cancer progression. One important function hypoxia and the hypoxia-inducible factors (HIF) maintenance stem-like cells (CSC), population tumor that possess stem cell-like properties drives growth. Among changes promoted by metabolic shift resulting in acidification microenvironment. Here, we show glioma acidosis functionally cooperate inducing HIF transcription CSC maintenance. We found...
<p>Supplementary Information including: Supplementary Materials and Methods References Figure S1: Expression of HIF target genes in cells exposed to varying O2, CO2 glucose levels. S2: Acidosis enhances the CSC phenotype. S3: Silencing HIF1/2 by siRNA. S4: HSP90 inactivation a dominant negative form reduces levels inhibits tumor growth. S5: Loss increases survival intratumoral levels.</p>
<p>Supplementary Information including: Supplementary Materials and Methods References Figure S1: Expression of HIF target genes in cells exposed to varying O2, CO2 glucose levels. S2: Acidosis enhances the CSC phenotype. S3: Silencing HIF1/2 by siRNA. S4: HSP90 inactivation a dominant negative form reduces levels inhibits tumor growth. S5: Loss increases survival intratumoral levels.</p>
In this work, a well-defined system of spherical monodispersed superparamagnetic core-shell Fe@Fe <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> O xmlns:xlink="http://www.w3.org/1999/xlink">4</inf> nanoparticles has been synthesized by thermal decomposition reaction. Before surface functionalization, the mean particle size was 14.1 nm ± 1.2 with bright shell thickness 1.3 0.4 nm. After ligand exchange more than doubled to 2.7 The...
<h2>Summary</h2> In early vertebrate development, organizer regions—groups of cells that signal to and thereby influence neighboring by secreted morphogens—play pivotal roles in the establishment maintenance cell identities within defined tissue territories. The midbrain-hindbrain drives regionalization neural into midbrain hindbrain territories with fibroblast growth factor 8 (FGF8) acting as a key morphogen. This has been extensively studied chicken, mouse, zebrafish. Here, we demonstrate...
Congenital aniridia (OMIM #106210) (ВА) is a Mendelian autosomal dominant panocular disorder with complete penetrance and variable expressivity. The incidence of 1 in 45,000-100,000 births. Aniridia characterized by congenital absence the iris foveal hypoplasia other eye abnormalities. most cases caused heterozygous mutations PAX6 gene or chromosome 11p13 rearrangements. Molecular analysis (including Sanger sequencing as well MLPA loss heterozygosity analysis) 110 patients referred from 84...