A5030814358- Bladder and Urothelial Cancer Treatments
- interferon and immune responses
- Immune cells in cancer
- Immune responses and vaccinations
- Single-cell and spatial transcriptomics
- Travel-related health issues
- Inflammasome and immune disorders
- Epigenetics and DNA Methylation
- Immune Response and Inflammation
- Island Studies and Pacific Affairs
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- HIV Research and Treatment
- Bacterial Identification and Susceptibility Testing
- Peptidase Inhibition and Analysis
- Kawasaki Disease and Coronary Complications
- vaccines and immunoinformatics approaches
- Cytomegalovirus and herpesvirus research
- Chemokine receptors and signaling
- Amino Acid Enzymes and Metabolism
- Influenza Virus Research Studies
- Cancer Research and Treatments
- Glycosylation and Glycoproteins Research
- COVID-19 epidemiological studies
- CAR-T cell therapy research
Institut Pasteur
2009-2023
Université Paris Cité
2022-2023
Centre National de la Recherche Scientifique
2020-2023
Inserm
2009-2017
Multisystem inflammatory syndrome in children (MIS-C) is a rare and severe condition that follows benign COVID-19. We report autosomal recessive deficiencies of OAS1 , OAS2 or RNASEL five unrelated with MIS-C. The cytosolic double-stranded RNA (dsRNA)–sensing generate 2′-5′-linked oligoadenylates (2-5A) activate the single-stranded RNA–degrading ribonuclease L (RNase L). Monocytic cell lines primary myeloid cells OAS1, OAS2, RNase produce excessive amounts cytokines upon dsRNA acute...
Humans display substantial interindividual clinical variability after SARS-CoV-2 infection1-3, the genetic and immunological basis of which has begun to be deciphered4. However, extent drivers population differences in immune responses remain unclear. Here we report single-cell RNA-sequencing data for peripheral blood mononuclear cells-from 222 healthy donors diverse ancestries-that were stimulated with or influenza A virus. We show that induces weaker, but more heterogeneous,...
No AccessJournal of UrologyAdult Urology1 Apr 2009Molecular Analyte Profiling the Early Events and Tissue Conditioning Following Intravesical Bacillus Calmette-Guerin Therapy in Patients With Superficial Bladder Canceris accompanied byIncreased Infiltration Tumor Associated Macrophages is Poor Prognosis Carcinoma In Situ After InstillationPrevention Treatment Transitional Cell Carcinomatosis Intraperitoneal Chemotherapy a Rat Model Aurélie Bisiaux, Nicolas Thiounn, Marc-Olivier Timsit, Ahmed...
There is considerable inter-individual and inter-population variability in response to viruses. The potential of monocytes elicit type-I interferon responses has attracted attention their role viral infections. Here, we use single-cell RNA-sequencing characterize the cellular heterogeneity human variation monocyte influenza A virus (IAV) exposure. We show widespread percentage IAV-infected monocytes. Notably, individuals with high susceptibility IAV are characterized by a lower activation at...
The ready access to commercially available multiplex assays and the importance of inflammation in disease pathogenesis has resulted an abundance studies aimed at identifying surrogate biomarkers for different clinically important questions. Establishing a link between biomarker pathogenesis, however, is quite complex, some instances this complexity compounded by post-translational modifications use immunoassays that do not always discriminate forms same protein. Herein, we provide detailed...
Bacillus Calmette-Guerin (BCG) is used as a vaccine and diagnostic test for tuberculosis, well immunotherapy in the treatment of bladder cancer. While clinically useful, response to mycobacterial stimulation complex induced protein signature remains poorly defined. We characterized cell types directly engaged by BCG, cytokine loops that transmit signal(s) bystander cells. Standardized whole blood stimulations mechanistic studies on single purified populations identified distinct patterns...
Treatment for non-muscle invasive carcinoma of the bladder represents one few examples successful tumor immunity. Six weekly intravesical instillations Bacillus Calmette-Guerin (BCG), often followed by maintenance schedule, result in up to 50–70% clinical response. Current models suggest that mechanism action involves non-specific activation innate effector cells, which may be capable acting absence an antigen-specific For example, recent evidence suggests BCG-activated neutrophils possess...
Background French Polynesia is a overseas collectivity in the Southeast Pacific, comprising 75 inhabited islands across five archipelagoes. The human settlement of region corresponds to last massive migration humans empty territories, but its timeline still debated. Despite their recent population history and geographical isolation, inhabitants experience health issues similar those continental countries. Modern lifestyles increased longevity have led rise non-communicable diseases (NCDs)...
Abstract Introduction: Forty years ago Zbar and colleagues demonstrated that bacillus calmette guérin (BCG) is capable of provoking an immune response against experimentally induced tumors. The conditions for successful tumor immunity were defined by a i) limited number cells in ii) close contact with iii) sufficient bacteria iv) the ability organism to mount BCG specific response. These findings led development what currently standard care treatment patients non-muscle invasive bladder...
Abstract Humans display vast clinical variability upon SARS-CoV-2 infection 1–3 , partly due to genetic and immunological factors 4 . However, the magnitude of population differences in immune responses mechanisms underlying such variation remain unknown. Here we report single-cell RNA-sequencing data for peripheral blood mononuclear cells from 222 healthy donors various ancestries stimulated with or influenza A virus. We show that induces a weaker, but more heterogeneous...
Abstract There is considerable inter-individual and inter-population variability in response to viruses. The potential of monocytes elicit type-I interferon responses has attracted attention their role viral infections. Here, we use an ex vivo model characterize the cellular heterogeneity human variation monocyte influenza A virus (IAV) exposure. Using single-cell RNA-sequencing, show widespread percentage IAV-infected monocytes. We that cells escaping infection display increased mRNA...
Abstract Background French Polynesia is a overseas collectivity in the Southeast Pacific, comprising 75 inhabited islands across five archipelagoes. The human settlement of region corresponds to last massive migration humans empty territories, but its timeline still debated. Despite their recent population history and geographical isolation, inhabitants experience health issues similar those continental countries. Modern lifestyles increased longevity have led rise non-communicable diseases...
You have accessJournal of UrologyBladder Cancer: Basic Research1 Apr 2011883 CONNAUGHT VERSUS TICE: COMPARISON OF THEIR EFFECTS IN VITRO AND THE INTRAVESICAL IMMUNE RESPONSE VIVO Claire Biot, Bisiaux Aurèlie, Helen Law, Joël Gsponer, Thomas Gasser, Alexander Bachmann, Matthew Albert, and Cyrill Rentsch BiotClaire Biot Paris, France More articles by this author , AurèlieBisiaux Aurèlie LawHelen Law GsponerJoël Gsponer Basel, Switzerland GasserThomas Gasser Liestal, BachmannAlexander Bachmann...
s: Abstracts for the 20th Annual Scientific Meeting of International Society Biological Therapy Cancer (Primary Authors are Italicized): IMMUNE MONITORING