A5044550530- Pharmacogenetics and Drug Metabolism
- Pharmaceutical studies and practices
- Antibiotics Pharmacokinetics and Efficacy
- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Drug Solubulity and Delivery Systems
- Blood Coagulation and Thrombosis Mechanisms
- Drug Transport and Resistance Mechanisms
- Statistical Methods in Clinical Trials
- Cardiac Arrhythmias and Treatments
- Photoacoustic and Ultrasonic Imaging
- Optical Imaging and Spectroscopy Techniques
- Advanced Drug Delivery Systems
- Computational Drug Discovery Methods
- Receptor Mechanisms and Signaling
- Analytical Chemistry and Chromatography
- Blood Pressure and Hypertension Studies
- Cardiac electrophysiology and arrhythmias
- Pneumonia and Respiratory Infections
- Metabolism and Genetic Disorders
- Analytical Methods in Pharmaceuticals
- Acute Myocardial Infarction Research
- Synthesis and Biological Evaluation
- Non-Invasive Vital Sign Monitoring
- Trypanosoma species research and implications
Bayer (Germany)
2015-2024
Columbus Oncology and Hematology Associates
2019-2021
University of Florida
2019
Helios Universitätsklinikum Wuppertal
2018
Hospital for Sick Children
2008
Heinrich Heine University Düsseldorf
1998-2005
Goethe University Frankfurt
2004
The aim of this tutorial is to introduce the fundamental concepts physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling with a special focus on their practical implementation in typical PBPK model building workflow. To illustrate basic steps building, for ciprofloxacin will be constructed and coupled pharmacodynamic simulate antibacterial activity treatment.
A physiologically based model for gastrointestinal transit and absorption in humans is presented. The can be used to study the dependency of fraction dose absorbed (F(abs)) both neutral ionizable compounds on two main physicochemical input parameters (the intestinal permeability coefficient (P(int)) solubility fluids (S(int))) as well physiological such gastric emptying time time. For permeability-limited compounds, produces established sigmoidal dependence between F(abs) P(int). In case...
Administering codeine to breast-feeding mothers had been considered safe until the recent death of a breast-fed neonate whose mother prescribed codeine. We investigated risk opioid poisoning neonates using coupled physiologically based pharmacokinetic models for and child. Neonatal morphine plasma concentrations were simulated various combinations cytochrome P450 2D6 (CYP2D6) genotype clearance, assuming typical schedules maternal doses ≤2.5 mg/kg/day. The simulations demonstrated that...
Because of the vulnerability and frailty elderly adults, clinical drug development has traditionally been biased towards young middle-aged adults. Recent efforts have begun to incorporate data from paediatric investigations. Nevertheless, often remain underrepresented in trials, even though persons aged 65 years older receive majority prescriptions. Consequently, a knowledge gap exists with regard pharmacokinetic (PK) pharmacodynamic (PD) responses subjects, leaving safety efficacy medicines...
Oral and intravenous formulations of ciprofloxacin have established efficacy safety profiles in respiratory infections. A dry powder for inhalation (DPI) that uses Novartis' PulmoSphere™ technology has been developed to deliver high concentrations the lung with low systemic exposure using a portable convenient passive inhaler (Novartis' T-326 inhaler). The primary objective was investigate tolerability DPI healthy male subjects, secondary pharmacokinetics after administration. This phase I,...
Proteins are an increasingly important class of drugs used as therapeutic well diagnostic agents. A generic physiologically based pharmacokinetic (PBPK) model was developed in order to represent at whole body level the fundamental mechanisms driving distribution and clearance large molecules like proteins. The built extension PK-Sim for small incorporating (i) two-pore formalism drug extravasation from blood plasma interstitial space, (ii) lymph flow, (iii) endosomal (iv) protection by...
Venous thromboembolism has been increasingly recognised as a clinical problem in the paediatric population. Guideline recommendations for antithrombotic therapy patients are based mainly on extrapolation from adult trial data, owing to limited number of trials populations. The oral, direct Factor Xa inhibitor rivaroxaban approved several thromboembolic disorders, and its well-defined pharmacokinetic pharmacodynamic characteristics efficacy safety profiles adults warrant further investigation...
Dose selection for "first in children" trials often relies on scaling of the pharmacokinetics from adults to children. Commonly used approaches are physiologically-based pharmacokinetic modeling (PBPK) and allometric (AS) combination with maturation clearance early life. In this investigation, a comparison two was performed provide insight into physiological meaning AS functions their interchangeability. The analysis focused established using paracetamol morphine paediatric data after...