Summary It has been suggested that preoperative fibrinogen plasma concentration is independently associated to postoperative blood loss after cardiac surgery.Theoretically, prophylactic infusion of concentrate may thus reduce bleeding, but this not previously investigated. Twenty elective coronary artery bypass graft (CABG) patients with levels <3.8 g/l were included in a prospective randomised pilot study. Patients receive an 2 g (FIB group) or no before surgery (control group). Primary...

BACKGROUND: Early identification of patients with increased risk excessive bleeding and transfusion after cardiac surgery offers the possibility to initiate countermeasures. Fibrinogen is a key protein in coagulation cascade thus potential biomarker for bleeding. We investigated relationship between preoperative fibrinogen plasma concentration postoperative coronary artery bypass grafting (CABG). STUDY DESIGN AND METHODS: A total 170 (mean age, 67 ± 9 years; 75% men) undergoing isolated CABG...

To evaluate the long-term use of secondary prevention medications [statins, β-blockers, renin-angiotensin-aldosterone system (RAAS) inhibitors, and platelet inhibitors] after coronary artery bypass grafting (CABG) association between medication mortality.

To determine the discriminative accuracy and calibration of EuroSCORE II in relation to age, sex, surgical risk a large nationwide coronary artery bypass grafting (CABG) cohort.All 14,118 patients undergoing isolated CABG Sweden during 2012-2017 were included. Individual patient data taken from SWEDEHEART registry. Patients divided by age (< 60, 60-69, 70-79, ≥ 80 years), (low: < 4%, intermediate: 4-8%, high: > 8%). Discriminative was determined area under receiver operating characteristic...

Background Little is known of the impact social factors on mortality after coronary artery bypass grafting ( CABG ). We explored sex- and age-specific associations between risk marital status, income, education. Methods Results This population-based register study included 110 742 patients (21.3% women) from SWEDEHEART registry (Swedish Web-system for Enhancement Development Evidence-based Care in Heart Disease Evaluated According to Recommended Therapies) operated 1992 2015. Cox regression...

Objective: We have recently reported that prophylactic fibrinogen infusion reduces bleeding after coronary artery bypass grafting (CABG) surgery. Because for the first time was administered to patients without hereditary deficiency or ongoing bleeding, a detailed analysis of effects concentrate on biomarkers coagulation, fibrinolysis, and platelet function performed. Methods: Twenty CABG with preoperative plasma levels &lt;3.8 g/L were included in prospective study. Patients randomized 2 g...

Background Low income and short education have been found to be independently associated with inferior survival after coronary artery bypass grafting ( CABG ), whereas the use of secondary prevention medications is improved survival. We investigated whether underusage contributes long‐term in patients a low education. Methods Results Patients who underwent Sweden between 2006 2015 survived at least 6 months discharge (n=28 448) were included population‐based cohort study. Individual patient...

We examined the long-term risk of dementia after coronary artery bypass grafting (CABG) in relation to age and sex.All CABG patients Sweden 1992-2015 (n = 111,335), matched controls 222,396) were included a population-based study. Adjusted hazard ratios (aHR) for all-cause dementia, vascular Alzheimer's disease calculated.There was no difference between control subjects (aHR 0.98 [95% confidence interval 0.95 1.02]). <65 years 65 74 had higher 1.29 [1.17-1.42] 1.08 [1.02-1.13],...

Excessive bleeding leading to re-exploration is a severe complication of cardiac surgical procedures, associated with early postoperative morbidity and mortality. Less known about the long-term outcome these patients. We evaluated impact after surgery on peri- mortality, as well in well-defined nationwide population.In this retrospective study, 48 060 consecutive patients undergoing coronary artery bypass grafting (CABG) and/or valve from 2006 2015 were analysed. Multivariable logistic...

Abstract Background We investigated whether fibrinogen concentrate administration to bleeding patients is associated with an increased risk of thromboembolic complications and death. Methods All consecutive who underwent first-time cardiac surgery at Sahlgrenska University Hospital from 2009 2014 were included. Patients, had received concentrate, compared those not concentrate. The primary endpoint was a composite death within 1 year after surgery. Secondary endpoints included the mortality...

To investigate the importance of blood sampling conditions for multiple electrode platelet aggregometry (MEA) in cardiac surgery patients.Eighty-one patients undergoing first time CABG were included three prospective, observational studies. MEA was used to analyze aggregability after addition adenosine-diphosphate (ADP) or thrombin activating peptide 6 (TRAP). In substudy 1, hirudin and citrate tubes compared. 2, samples from peripheral vein, central venous catheter, radial artery compared...

Fibrinogen concentrate is used clinically to improve hemostasis in bleeding patients. We investigated and compared the efficacy of three commercially available fibrinogen concentrates clot strength blood samples from cardiac surgery patients.Postoperative were collected 23 Samples each divided into four vials, supplemented with 1.125 mg one (RiaSTAP® , Fibryga® FibCLOT® ), or placebo. The dose corresponded 2.5 g per 70 kg body weight. Clot after supplementation was assessed duplicate...

Previous reports suggest that betablockers appear non-beneficial after surgical aortic valve replacement (SAVR). This study aims to clarify the associations between and long-term outcome SAVR.

Obstructive sleep apnea (OSA) is associated with atrial fibrillation (AF) in cardiac cohorts. Less known regarding the magnitude of this association a clinic cohort vs. without excessive daytime sleepiness (EDS).

Summary Objectives To investigate if supplementation with fibrinogen concentrate to blood samples collected after tranexamic acid administration improve clot formation more than what can be achieved in the absence of acid. Background It is not known combination and has additional effects individually. Methods Four were from 15 coronary artery bypass patients. Two before surgery, 2 g was administered. The preoperative diluted haematocrit 21%. a second dose Fibrinogen corresponding 3 70‐kg...

(Abstracted from Br J Anaesth,116(2):208–214, 2016) Excessive bleeding after cardiac surgery is a serious complication associated with increased morbidity and mortality linked to number of causes, including low plasma fibrinogen concentration. Fibrinogen key factor in coagulation.

Abstract Background Previous studies investigating the association between coronary artery bypass grafting (CABG) and risk for dementia show conflicting results. Purpose To compare long-term in CABG patients to matched individuals general population, identify independent predictors developing after CABG. Methods Data from SWEDEHEART registry three other mandatory national registries were merged all who underwent isolated Sweden 1992 2015 (n=111.335) with an age- sex-matched control...

Abstract BACKGROUND To determine the discriminative accuracy and calibration of EuroSCORE II in relation to age, sex, surgical risk a large nationwide coronary artery bypass grafting (CABG) cohort. METHODS All 14118 patients undergoing isolated CABG Sweden during 2012–2017 were included. Individual patient data taken from SWEDEHEART registry. Patients divided by age (&lt;60, 60–69, 70–79, ≥80 years), (low: &lt;4%, intermediate: 4–8%, high: &gt;8%). Discriminative was determined area under...