A5018469291- Congenital Heart Disease Studies
- Cardiovascular and Diving-Related Complications
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Conditions and Treatments
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac Structural Anomalies and Repair
- Cardiac Arrhythmias and Treatments
- Coronary Artery Anomalies
- Mechanical Circulatory Support Devices
- Cardiomyopathy and Myosin Studies
- Viral Infections and Immunology Research
- Tracheal and airway disorders
- Cardiovascular Issues in Pregnancy
- Renal and Vascular Pathologies
- Transplantation: Methods and Outcomes
- Infective Endocarditis Diagnosis and Management
- Pregnancy and preeclampsia studies
- Congenital Diaphragmatic Hernia Studies
- Neonatal Respiratory Health Research
- Cardiovascular Effects of Exercise
- Blood disorders and treatments
- Acute Myeloid Leukemia Research
University of Helsinki
2015-2024
Helsinki University Hospital
2013-2024
Hospital Universitario Virgen de la Arrixaca
2024
Turku University Hospital
2022-2023
ERN GUARD-Heart
2023
University of Turku
2022
Children's Hospital
2015
University of Toronto
1999-2007
Hospital for Sick Children
1999-2001
SickKids Foundation
1999-2001
In a double blind study of 58 episodes fever and profound neutropenia, children with cancer received either recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) or placebo, combined identical antimicrobial therapy, i.e. imipenem, on admission. The criteria for discontinuation therapy were identical. A difference was demonstrated both in the number hospital days, totaling 252 days rhGM-CSF group 354 placebo group, receiving antibiotics (220 vs. 322), resolution...
Transcatheter (TC) atrial septal defect (ASD) closure has been the mainstay of therapy for secundum-type ASDs over 20 years.This nationwide cohort evaluated long-term outcome transcatheter-closed ASDs.The study enrolled every transcatheter ASD performed in Finland from 1999 to 2019. Five age, sex, and municipality-matched controls per patient were gathered general population. The median follow-up period was 5.9 years (range 0-20.8). We used hospital discharge register gather all visits...
Objective To evaluate whether a nationwide prenatal anomaly screening programme improves detection rates of univentricular heart ( UVH ) and transposition great arteries TGA ), maternal risk factors for severe fetal disease affect detection. Design Population‐based cohort study. Setting Nationwide data from Finnish registries 2004–14. Population A total 642 456 parturients 3449 terminated pregnancies due to anomaly. Methods Prenatal were calculated in three time periods (prescreening,...
Surgical strategy to construct a two-coronary system for patient with anomalous origin of left coronary artery from pulmonary (ALCAPA) has evolved time. Limited long-term follow-up data are available on these children. We report population-based in children operated ALCAPA. In total, 29 patients underwent aortic reimplantation ALCAPA between 1979 and 2006. Twenty (69%) were repaired direct implantation, five (17%) modified tubular extension technique, four (14%) an intrapulmonary baffling...
The purpose of this study was to evaluate the long-term outcomes Ross procedure in a nationwide follow-up. This retrospective involved all children treated with Finland between 1994 and 2009. clinical records were reviewed for demographic anatomical characteristics, operation data, surgical history status at latest median follow-up time 11.5 (range 2.4–19.2) years. Fifty-one patients underwent either (n = 37) or Ross-Konno 14) age 4.8 0.02–16.3) years, including 13 infants (<1 year age)....
Abstract Objective: This study was to review an institutional experience with transcatheter closure of Fontan fenestrations and its impact on clinical care. Background: An interatrial fenestration improves postoperative outcomes in high‐risk children undergoing a repair. While technical feasibility has been well defined, the subsequent is not defined. Methods: Transcatheter surgically created or additional communication attempted 152 at median interval 13.8 months after surgery. The records...
To evaluate serum levels of cardiac troponin I (cTnI), autoantibodies against (cTnAAbs) and natriuretic peptides during the treatment protocol in children with hypoplastic left heart syndrome (HLHS). In a prospective study, we had 18 consecutive HLHS, for whom samples were analysed before Norwood operation, bidirectional Glenn (BDG) at age one year total cavo-pulmonary connection (TCPC). addition, performed cross-sectional study 22 examined TCPC. Controls comprised 34 healthy children. was...
To evaluate the prevalence of cardiac troponin I (cTnI) and autoantibodies to cTn in children with congenital heart defects volume or pressure overload fulfilling criteria for treatment, healthy children.The study groups comprised 78 caused by an atrial septal defect a patent ductus arteriosus, 60 coarctation aorta stenosis aortic pulmonary valve, 74 controls. Serum levels natriuretic peptides, cTnI, were analyzed at baseline, prior treatment 64 patients 6 months after treatment.At one child...
The aim of the study was to evaluate cardiopulmonary exercise tolerance in children and adolescents after chest irradiation anticancer chemotherapy.We studied 30 subjectively asymptomatic patients aged 8 25 years treated for pediatric malignancies with (XRT) +/- chemotherapy. median interval since XRT 7 (range, 2 13) years. dose mediastinum and/or lungs 2550 1000 5100) cGy. cumulative anthracyclines 250 0 480) mg/m2. Cardiac function were evaluated by electrocardiography, echocardiography,...
A restrictive interatrial communication can complicate the management of complex congenital heart disease. The purpose this report is to present a new technique achieve patent and reliable by using an endovascular stent. stent was successfully implanted across fenestrated extracardiac conduit in two patients with low cardiac output after Fontan operations septum patient double inlet left ventricle severe atrioventricular stenosis. procedures were uncomplicated all showed immediate...
Abstract Objectives : Hemodynamic effects of surgical and percutaneous closure atrial septal defect (ASD) were evaluated. Background ASD causes volume overload right ventricle (RV) is associated with distortion dysfunction left (LV). The amount timing hemodynamic changes after are not well known. Methods study group consisted 7 children treated surgically 17 in the catheterization laboratory. In control group, there 51 healthy children. RV size LV end‐diastolic systolic dimensions, volumes,...
AimsVelocity vector imaging (VVI) is an echocardiographic technique based on speckle tracking, which has been validated for the left ventricle (LV). It not to assess systemic right (RV) in patients with hypoplastic heart syndrome (HLHS). The aim of this study was evaluate whether VVI measurements reliably reflect RV systolic function HLHS when compared ejection fraction (EF) calculated using magnetic resonance (MRI).
Mutations in the LMNA gene coding for nuclear lamina proteins lamin A and its smaller splice form C associate with a heterogeneous group of diseases collectively called laminopathies. Here, we describe 2-year-old patient previously undescribed phenotype including right ventricular cardiomyopathy, progeroid features, premature death. Sequencing revealed novel heterozygous de novo mutation p.L306R located α-helical rod domain A-type lamins. Fibroblasts from showed reduced proliferation early...
Abstract Twenty children 1–17 (median, 5.5) years of age received GM‐CSF during chemotherapy‐induced neutropenia at the dose 5 μg/kg/day, continued until absolute neutrophil count (ANC) exceeded 500 × 10 6 /liter. Twelve with solid tumors after courses conventional chemotherapy (VP‐16 + ifosfamide or “6 in 1”). One course followed by was compared to identical without same patients. Eight recurrent/poor risk malignancies marrow‐ablative therapy and autologous bone marrow transplantation...
Hypoplasia of the transverse aortic arch is commonly associated with coarctation. Persistent or recurrent obstruction can occur at this level after successful repair native coarcted segment. The purpose report to present a new technique treat such lesions, namely implantation balloon-expandable stent. This approach was used successfully in 4 children hypoplasia occurring Implantation led both anatomical and physiological relief all. patients tolerated procedure, there were no major adverse events.
We studied the long-term survival and rejection episodes of paediatric heart transplant recipients.We included all patients (≤18 years) who underwent transplantation during 1991-2014 in Finland. Data were obtained retrospectively from a cardiac surgery database. Patient status was received Finnish population registry. All yearly routine postoperative endomyocardial biopsies coronary angiographies.Between 1991 2014, 68 transplantations performed. The early mortality (<30 days after surgery)...