A5101601428- Congenital Heart Disease Studies
- MicroRNA in disease regulation
- Congenital heart defects research
- RNA modifications and cancer
- Ethnobotanical and Medicinal Plants Studies
- Essential Oils and Antimicrobial Activity
- Joseph Conrad and Literature
- Protease and Inhibitor Mechanisms
- Genomics and Rare Diseases
- DNA Repair Mechanisms
- Circular RNAs in diseases
- Cardiac Valve Diseases and Treatments
- Genetic Syndromes and Imprinting
- Cancer, Stress, Anesthesia, and Immune Response
- Plant tissue culture and regeneration
- Coronary Artery Anomalies
- Medicinal Plants and Neuroprotection
- Extracellular vesicles in disease
- Cancer-related Molecular Pathways
- RNA Interference and Gene Delivery
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Seed and Plant Biochemistry
- Cancer Cells and Metastasis
- Histone Deacetylase Inhibitors Research
Indian Institute of Chemical Biology
2020-2025
Chittaranjan National Cancer Institute
2020-2024
Stanford University
2017-2023
Indian Agricultural Research Institute
2022-2023
Lucile Packard Children's Hospital
2019-2023
Seattle Children's Hospital
2021-2023
University of Washington
2020-2023
Bangladesh Agricultural University
2022
Jadavpur University
2022
R. G. Kar Medical College and Hospital
2021
Although lower-complexity cardiac malformations constitute the majority of adult congenital heart disease (ACHD), long-term risks adverse cardiovascular events and relationship with conventional risk factors in this population are poorly understood. We aimed to quantify associated ACHD that is unmeasured by factors.A multitiered classification algorithm was used select individuals without for comparison among >500 000 British adults UK Biobank. diagnoses were subclassified as isolated aortic...
Biomedical repositories such as the UK Biobank provide increasing access to prospectively collected cardiac imaging, however these data are unlabeled, which creates barriers their use in supervised machine learning. We develop a weakly deep learning model for classification of aortic valve malformations using up 4,000 unlabeled MRI sequences. Instead requiring highly curated training data, weak supervision relies on noisy heuristics defined by domain experts programmatically generate...
Abstract Exosomes are nano‐scale vesicles involved in intercellular communication and have a significant role cancer progression. Tetraspanins, transmembrane proteins enriched exosomes. These exosome biogenesis, cargo sorting,and target‐cell interactions, influencing tumor development therapeutic response. Exosomal tetraspanins, including CD9, CD63, CD81, Tspan8, contribute to cell proliferation, angiogenesis, extracellular matrix remodelling, immune evasion, promote metastasis. Their...
Abstract Background and Purpose Chemoresistance tumour relapse pose significant challenges in achieving successful chemotherapy outcomes. Targeting DNA polymerase eta (Pol ƞ)‐mediated mutagenic translesion synthesis (TLS) has emerged as a promising strategy for improving chemotherapy. However, the identification of small molecule inhibitors targeting Pol ƞ ‐ mediated TLS with high vivo efficacy remains challenge. Experimental Approach The was identified through silico screening. η inhibitory...
This paper takes a closer look at Babasaheb: The Grand Musical, theatrical production put together by the Delhi state government in 2022. musical tells story of Dr. Bhim Rao Ambedkar, one India's most influential figures, who played key role shaping country’s Constitution. While generated lot buzz and drew large crowds, it also raises important questions about how Ambedkar’s legacy is represented today. By analyzing through frameworks popular aesthetics, culture, cultural labor, argues that...
Ruta chalepensis L. (Rutaceae), a perennial herb with wild and cultivated habitats, is well known for its traditional uses as an anti-inflammatory, analgesic, antipyretic agent, in the treatment of rheumatism, nerve diseases, neuralgia, dropsy, convulsions mental disorders. The antimicrobial activities crude extracts from fruits, leaves, stem roots R. were initially evaluated against two Gram-positive Gram-negative bacterial strains strain fungus Candida albicans. Phytochemical investigation...
Abstract Loss of function variants in NOTCH1 cause left ventricular outflow tract obstructive defects (LVOTO). However, the risk conferred by rare and noncoding for LVOTO remains largely uncharacterized. In a cohort 49 families affected hypoplastic heart syndrome, severe form LVOTO, we discovered predicted loss 6% individuals. Rare or low‐frequency missense were found 16% families. To make quantitative estimate genetic posed studied associations 400 coding 1,085 cases 332,788 controls from...
Deletion of a non-imprinted 500kb genomic region at chromosome 15q11.2, between breakpoints 1 and 2 the Prader-Willi/Angelman locus (BP1-BP2 deletion), has been associated in previous studies with phenotypes including congenital cardiovascular malformations (CVM). Previous investigating association BP1-BP2 deletion CVM have tended to recruit cases rarer more severe phenotypes; impact on relatively unselected population cohorts, anticipated contain chiefly less but commoner CHD phenotypes, is...
Background Neurocognitive impairment is a common complication of congenital heart disease (CHD) as well acquired cardiovascular disease. Data are limited on neurocognitive function in adults with CHD (ACHD). Methods and Results A total 1020 individuals mild‐to‐moderate ACHD 497 987 without from the volunteer‐based UK Biobank study underwent tests for fluid intelligence, reaction time, numeric memory, symbol‐digit substitution, trail making at enrollment follow‐up. Performance scores were...