A5019292973- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- RNA modifications and cancer
- Histone Deacetylase Inhibitors Research
- Caveolin-1 and cellular processes
- Autophagy in Disease and Therapy
- Genomics and Chromatin Dynamics
- MicroRNA in disease regulation
- Lipid metabolism and biosynthesis
- Pluripotent Stem Cells Research
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Neonatal Health and Biochemistry
- Protein Interaction Studies and Fluorescence Analysis
- Crystallography and molecular interactions
- Clusterin in disease pathology
- Lipid Membrane Structure and Behavior
- RNA Research and Splicing
- Ferroptosis and cancer prognosis
- Prostate Cancer Treatment and Research
- COVID-19 Clinical Research Studies
- Hedgehog Signaling Pathway Studies
- Biomedical Research and Pathophysiology
National Institute of Technology Rourkela
2016-2025
National Institute of Technology
2022-2024
Maulana Azad National Institute of Technology
2024
Indian Institute of Technology BHU
2021-2024
Banaras Hindu University
2021-2024
Haldia Institute of Technology
2023
S.N. Bose National Centre for Basic Sciences
2023
Ispat General Hospital
2019
Indian Institute of Technology Kanpur
2015
Chhatrapati Shahu Ji Maharaj University
2015
In the present study, we report aqueous extract of Pithophora oedogonia to produce silver nanoparticles (AgNPs) by reduction nitrate. It was noted that synthesis process considerably rapid and were generated within few minutes ions coming in contact with algal extract. A peak at 445 nm corresponding plasmon absorbance AgNPs UV–vis spectrum medium contained ions. Scanning electron microscopic (SEM) dynamic light scattering analysis colloidal indicated size 34.03 nm. Energy-dispersive X-ray...
Abstract Recent studies have shown that cytosine‐5 methylation at CpG islands in the regulatory sequence of a gene is one key mechanisms inactivation. The enzymes responsible for are DNA methyltransferase (DNMT) 1, DNMT3a, and DNMT3b, enzyme demethylation demethylase (MBD2). Studies on methylation‐demethylation lacking human prostate cancer. We hypothesize MBD2 activity repressed DNMT1 elevated To test this hypothesis, we analyzed activities, mRNA, protein levels DNMT1, DNMT3b cancer cell...
Abstract Mechanical forces may be generated within a cell due to tissue stiffness, cytoskeletal reorganization, and the changes (even subtle) in cell's physical surroundings. These of impose mechanical tension intracellular protein network (both cytosolic nuclear). could released by series protein–protein interactions often facilitated membrane lipids, lectins sugar molecules thus generate type signal drive cellular processes, including differentiation, polarity, growth, adhesion, movement,...
DNA methylation mediates gene silencing primarily by inducing repressive chromatin architecture via a common theme of interaction involving methyl-CpG binding (MBD) proteins, histone modifying enzymes and remodelling complexes. Hence, targeted inhibition MBD protein function is now considered potential therapeutic alternative for thwarting hypermethylation prompted neoplastic progress. We have analyzed the expression level principal factors responsible silencing, that is, DNMT proteins in...
Four novel dimeric bis-μ-imido bridged metal–metal bonded oxidomolybdenum(V) complexes [MoV2O2L′21–4] (1–4) (where L′1–4 are rearranged ligands formed in situ from H2L1–4) and a new mononuclear dioxidomolybdenum(VI) complex [MoVIO2L5] (5) synthesized salen type N2O2 reported. This rare series of imido-bridged have been furnished H3L′1–4 ligands, containing an aromatic diimine (o-phenylenediamine) "linker", where Mo assisted hydrolysis followed by −C═N bond cleavage one the arms ligand H2L1–4...
SOX2 plays a crucial role in tumor development, cancer stem cell maintenance, and progression. Mechanisms of gene regulation human breast prostate cancers are not established yet.SOX2 expression tissues lines was determined by qRT-PCR, Western blot, immunochemistry, followed the investigation pro-tumorigenic properties like proliferation, migration, apoptosis knockdown treatment with epigenetic modulators ChIP.Prostate showed very high SOX2. All DU145 PC3 (prostate) MCF7 MDA-MB-231 (breast)...
Mitophagy involves the selective elimination of defective mitochondria during chemotherapeutic stress to maintain mitochondrial homeostasis and sustain cancer growth. Here, we showed that CLU (clusterin) is localized induce mitophagy controlling damage in oral cells. Moreover, overexpression knockdown establish its mitophagy-specific role, where acts as an adaptor protein coordinately interacts with BAX LC3 recruiting autophagic machinery around damaged response cisplatin treatment....