A5068209853- Congenital Heart Disease Studies
- Cardiovascular Conditions and Treatments
- Cardiovascular Issues in Pregnancy
- Congenital Diaphragmatic Hernia Studies
- Aortic Disease and Treatment Approaches
- Tracheal and airway disorders
- Cardiovascular Function and Risk Factors
- Neonatal Respiratory Health Research
- Cardiac Valve Diseases and Treatments
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Non-Invasive Vital Sign Monitoring
- Metabolism and Genetic Disorders
- Mechanical Circulatory Support Devices
- Cardiovascular and Diving-Related Complications
- Monoclonal and Polyclonal Antibodies Research
- Infant Development and Preterm Care
- Cardiac Arrhythmias and Treatments
- Hemodynamic Monitoring and Therapy
- Ultrasound in Clinical Applications
- Retinopathy of Prematurity Studies
- Coronary Artery Anomalies
- Systemic Lupus Erythematosus Research
- Diabetes Management and Research
- Cardiac Imaging and Diagnostics
- Transplantation: Methods and Outcomes
University of Gothenburg
1990-2025
Sahlgrenska University Hospital
2015-2025
University of California, San Francisco
2022
Drottning Silvias barn- och ungdomssjukhus
2001-2020
University of Birmingham
2019
National Center on Birth Defects and Developmental Disabilities
2019
Centers for Disease Control and Prevention
2019
William Paterson University
2019
Starship Children's Health
2018-2019
Leiden University Medical Center
2019
<b>Objective</b> To evaluate the use of pulse oximetry to screen for early detection life threatening congenital heart disease. <b>Design</b> Prospective screening study with a new generation oximeter before discharge from well baby nurseries in West Götaland. Cohort comparing rate duct dependent circulation Götaland that other regions not using screening. Deaths at home undetected were included. <b>Setting</b> All 5 maternity units and supraregional referral centre neonatal cardiac surgery....
Isolated complete atrioventricular block in the fetus is a rare but potentially lethal condition which effect of steroid treatment on outcome unclear. The objective this work was to study risk factors associated with death and influence outcome.We studied 175 fetuses diagnosed second- or third-degree (2000-2007) retrospectively multinational, multicenter setting. In 80% 162 pregnancies documented antibody status, maternal anti-Ro/SSA antibodies. Sixty-seven cases (38%) were treated...
Background— Prenatal diagnosis of aortic coarctation suffers from high false-negative rates at screening and poor specificity. Methods Results— This retrospective study tested the applicability published arch ductal Z scores (measured just before descending aorta in 3-vessel tracheal view) their ratio on 200 consecutive normal controls a median 22±0 gestational weeks (range, 15±4 to 38±4 weeks). Second, this ability serial distinguish fetuses with within cohort ventricular and/or great...
Prenatal screening for foetal cardiac abnormalities has been increasingly practiced in Sweden during the last 25 years. A prenatal diagnosis may have medical benefits but also cause sustained parental psychological distress. The aim of this study was to explore pregnant women’s, and their partner’s, experiences counselling need support continued pregnancy following a defect. second use information propose structured follow-up programme after first counselling. Design: Qualitative study,...
Prenatal diagnosis of isolated coarctation the aorta suffers from high false positive and negative rates. The aim our study was to develop Z-scores for aortic isthmus in normal fetuses as a reference with suspected coarctation.The isthmal diameter, immediately proximal insertion arterial duct, measured prospectively transverse (three vessel trachea) sagittal views 221 at 18 37 weeks' gestation. ductal diameter before it entered descending same view. All measurements were repeated three times...
To determine what proportion of newborns with critical heart defects are discharged undiagnosed from the maternity ward.Data were retrieved retrospectively for infants born in our referral area 1993 to 2001 and undergoing surgical or catheter-based intervention before 2 mo age because defects.259 full-term had defects. Duct-dependent systemic circulation was present 129, duct-dependent pulmonary 106, 24 not duct dependent but critically ill. In 51 (20%) defect suspected discharge ward. Such...
To investigate whether prenatal screening is effective in the detection of total anomalous pulmonary venous connection (TAPVC) and to identify common features.This was a retrospective collaborative study involving 19 pediatric cardiac centers UK, Ireland Sweden. Cases with TAPVC born between January 1, 1998 December 31, 2004, prenatally diagnosed cases whose estimated dates delivery were within this time frame, identified. functionally univentricular circulation or atrial isomerism excluded....
Fetal aortic valvuloplasty (FV) aims to prevent fetal valve stenosis progressing into hypoplastic left heart syndrome (HLHS), which results in postnatal univentricular (UV) circulation. Despite increasing numbers of FVs performed worldwide, the natural history disease life remains poorly defined. The primary aim this study was describe stenosis, and a secondary test previously published criteria designed identify cases emerging HLHS with potential for biventricular (BV) outcome after FV.From...
Abstract Aim : To evaluate the feasibility of detecting duct‐dependent congenital heart disease before hospital discharge by using pulse oximetry. Design Case‐control study. Setting A supra‐regional referral centre for paediatric cardiac surgery in Sweden. Patients 200 normal term newborns with echocardiographically hearts (median age 1.0 d) and 66 infants critical (CCHD; median 3 d). Methods: Pulse oximetry was performed right hand one foot a new‐generation oximeter (NGoxi)...
Objective Congenital heart block may develop in the fetuses of Ro/SSA-positive and La/SSB-positive mothers. Recurrence rates only 10–20% despite persisting maternal antibodies indicate that additional factors are critical for establishment block. The authors investigated influence other fetal on development a Swedish population-based cohort. Methods gender, age, parity time birth was analysed 145 families, including Ro/La-positive (n=190) Ro/La-negative (n=165) pregnancies. Results There...
Fetal aortic stenosis may progress to hypoplastic left heart syndrome. valvuloplasty (FV) has been proposed improve hemodynamics and maintain biventricular (BV) circulation. The aim of this study was assess FV efficacy by comparing survival postnatal circulation between fetuses that underwent those did not.This a retrospective multicenter with 2005 2012, compared contemporaneously enrolled natural history (NH) cases sharing similar characteristics at presentation but not undergoing FV. Main...
Pulse oximetry screening of newborn infants increases early detection critical congenital heart disease and minimises the risk circulatory collapse before surgery. This study provides an update on implementation pulse in Nordic countries proposes standardised guidelines.A questionnaire exploring screening, clinical examination routines availability echocardiography was distributed to all 157 delivery units June 2013.We received responses from 156 units, 116 (74%) were using by September...
OBJECTIVES: To determine what contribution prenatal ultrasound screening and neonatal pulse oximetry (POS) make to the timely diagnosis of coarctation aorta (CoA). METHODS: We identified infants fetuses diagnosed with isolated CoA in our referral area between 2003 2012 who died without surgery, underwent surgical repair before 2 months age, or were terminated after a diagnosis. Clinical data collected from hospital charts. RESULTS: Only 3 90 cases prenatally. Two born alive 1 case couple...
ABSTRACT Aim Newborn infants with critical aortic arch obstruction are often undiagnosed at discharge, despite screening. This study investigated if adding the perfusion index improved early detection. Methods We retrospectively studied 38 newborn obstruction, who were routinely screened in 2014–2019 by 13 Swedish hospitals using pulse oximetry and index. They identified through surgery records national mortality databases. The controls 512 healthy from one hospital. Optimal cut‐offs...
Abstract Introduction: A diagnosis of congenital heart disease (CHD) in offspring triggers psychological distress parents. Results previous studies have been inconsistent regarding the impact a prenatal versus postnatal diagnosis. The aim this study was to evaluate influence time on levels parental distress. Methods: Pregnant women and their partners with fetus diagnosed complex CHD, parents children postnatally pregnant uncomplicated pregnancies were invited participate. Data collected...
This report evaluates results of a screening program on prenatal detection congenital heart defects in geographical cohort western Sweden between January 1st, 2013 and June 31st, 2017. During the study period 88,230 children were born VGR.Retrospective data pregnant women from Västra Götaland region that referred to fetal cardiologists Gothenburg retrieved. To determine rate, all neonates who underwent surgery or catheter intervention for critical defect 2014 December 2016 included. The...
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ABSTRACT. A group of 91 children with birthweights below 2000 g and 48 healthy full‐term children, reference group, were examined for mineralization disturbances the enamel deciduous teeth. Perinatal data collected retrospectively from obstetric neonatal records. Within low birthweight hypoplasia had on 5% level a significantly lower intake breast milk during first week life than without disturbances. The only perinatal complication associated development defects was IRDS. Infants IRDS,...
The objective of the study was to investigate antigen specificity and occurrence individual autoantibodies in mothers children diagnosed with atrioventricular (AV) block a nation-wide setting. Patients AV detected before 15 years age were identified using national quality registries as well network pediatric adult cardiologists rheumatologists at six university hospitals Sweden. gross heart malformations, surgically or infectiously induced blocks excluded. Blood samples obtained from...
Background Norwood surgery provides a palliative surgical option for hypoplastic left heart syndrome and has been available in Sweden since 1993. The practice of prenatal ultrasound screening was gradually implemented the same era, resulting an increased detection rate. Our primary aims were to study changes incidence live births, rate, termination pregnancies over time. secondary proportion live-borns undergoing identify factors that influenced whether or not performed. Methods Results...
We aimed to investigate the frequency of necrotising enterocolitis (NEC) in infants with critical congenital heart disease (CCHD) hypothesising that preoperative enteral feeding does not increase risk NEC.When NEC affects term infants, underlying factors such as asphyxia, sepsis or CCHD are often found. Due fear development great caution is practised many countries defer feeding, but Sweden this routinely provided.An observational study all born who were admitted Queen Silvia Children's...
Early diagnosis of critical congenital heart defects (CCHD) improves survival. We evaluated the relative contributions prenatal ultrasound, neonatal pulse oximetry screening (POS), and physical examination (NPE) to early detection (before discharge) CCHD in context increasing detection, POS being a national standard since 2013.Retrospective, nationwide population-based study. All full-term live-born infants with Sweden between 2014 2019 were included. was defined as defect requiring surgery...