A5035847805- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Viral Infections and Immunology Research
- Cardiomyopathy and Myosin Studies
- Cardiovascular Effects of Exercise
- Cardiac pacing and defibrillation studies
- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Congenital Heart Disease Studies
- Sarcoidosis and Beryllium Toxicity Research
- Cardiac Arrhythmias and Treatments
- Rheumatoid Arthritis Research and Therapies
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Cardiac electrophysiology and arrhythmias
- Transplantation: Methods and Outcomes
- Systemic Lupus Erythematosus Research
- Atomic and Subatomic Physics Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Acute Lymphoblastic Leukemia research
- Cardiac Fibrosis and Remodeling
- Nuclear Structure and Function
- Sports injuries and prevention
- Acute Myocardial Infarction Research
Helsinki University Hospital
2015-2024
University of Helsinki
2013-2024
Hospital District of Helsinki and Uusimaa
2019
Research International (United States)
1988
The purpose of this study was to identify early features lamin A/C gene mutation related dilated cardiomyopathy (DCM) with cardiovascular magnetic resonance (CMR). We characterise myocardial and functional findings in carriers facilitate the recognition these patients using method. also investigated connection between fibrosis conduction abnormalities.
Background: Autosomal dominantly inherited PRKAG2 cardiac syndrome is due to a unique defect of the cell metabolism and has distinctive histopathology with excess intracellular glycogen, prognosis different from sarcomeric hypertrophic cardiomyopathy.We aimed define distinct characteristics using cardiovascular magnetic resonance (CMR).Methods: CMR (1.5 T) genetic testing were performed in two families harboring mutations.On CMR, segmental analysis left ventricular (LV) hypertrophy (LVH),...
Mutations in the LMNA gene encoding lamins A and C of nuclear lamina are a frequent cause cardiomyopathy accounting for 5-8% familial dilated (DCM). Our aim was to study disease onset, presentation progression among mutation carriers.Clinical follow-up data from 27 carriers 78 patients with idiopathic DCM without an were collected. In addition, ECG collected analysed systematically 20 healthy controls.Kaplan-Meier analysis revealed no difference event-free survival (death, heart transplant,...
Background Magnetic resonance imaging (MRI) in patients with cardiac pacing devices has become available despite previously being considered absolutely contraindicated. However, most institutional safety protocols have included several limitations on patient selection, leaving MRI unavailable for many patients. Purpose To evaluate the first 1000 examinations conducted at Helsinki University Hospital any potential hazards and also to long-term functionality of protocol “real-life” clinical...
Suspected nonischemic cardiomyopathy (NICM) is a common clinical setting with highly variable prognosis. Early noninvasive risk-stratification important for justification of invasive examinations, specific treatment and patient surveillance. We studied the additional prognostic value late gadolinium enhancement (LGE) segmental wall motion abnormality (SWMA) extent on cardiovascular magnetic resonance (CMR) compared to traditional risk factors in suspected NICM. In this observational cohort...
The present series describes a group of adults with left-to-right shunts including partial anomalous pulmonary venous return (PAPVR) and/or an atrial septal defect (ASD) evaluated ECG-gated 128-slice multidetector computed tomography (MDCT). PAPVR is defined as shunt where one or more, but not all, veins drain into systemic vein the right atrium. involving upper can be associated sinus venosus ASD. presence, course, number and cardiovascular defects reliably observed by MDCT angiography.
Background Some myocardial diseases, such as cardiac sarcoidosis, predispose to complete atrioventricular block. The European Society of Cardiology Guidelines on pacing in 2021 recommend disease screening patients with conduction disorder requiring pacemaker multimodality imaging, including magnetic resonance (CMR) imaging. ability CMR imaging detect a temporary wire is not well documented. Methods and Results Our protocol based using an active fixation lead connected reusable extracorporeal...
Abstract Objectives Cardiac implantable electronic device (CIED)–induced metal artefacts possibly significantly diminish the diagnostic value of magnetic resonance imaging (MRI), particularly cardiac MR (CMR). Right-sided generator implantation, wideband late-gadolinium enhancement (LGE) technique and raising ipsilateral arm to during CMR scanning may reduce CIED-induced image artefacts. We assessed impact location arm-raised position on in CMR. Methods included all clinically indicated CMRs...
Abstract Background Early studies have suggested increased risk of fatal cardiac complications in infants with Shwachman–Diamond syndrome (SDS), an inherited bone marrow failure syndrome. Patients undergoing stem cell transplantation (STC) appeared susceptible to organ toxicity, including involvement. Procedure This study assessed anatomical and functional features the heart SDS. Eight patients (mean age 24.1 years, range 7–37 seven males) SDS confirmed SBDS mutations were prospectively for...
The atrial appendages are a tissue reservoir for cardiac stem cells. During on-pump coronary artery bypass graft (CABG) surgery, part of the right appendage can be excised upon insertion cannula heart-lung machine. In operating room, removed easily cut into micrografts transplantation. This trial aims to assess safety and feasibility epicardial transplantation in patients undergoing CABG surgery. Autologous made from leftover during 6 patients. Atrial is mechanically processed consisting...
Background Magnetic resonance imaging (MRI) of pacemaker patients has become available despite previous contraindications. However, pacing systems containing ferromagnetic material may hamper the diagnostic quality cardiac MR (CMR) images. Purpose To study methods for reducing susceptibility-based artifacts in CMR examinations patients. Material and Methods Altogether 16 were scanned with 1.5T MRI scanner using cine balanced steady-state free-precession (bSSFP) spoiled gradient echo (SPGR)...
Large myocardial infarction (MI) is associated with adverse left ventricular (LV) remodeling (LVR). We studied the nature of LVR, specific attention to non-transmural MIs, and association peak CK-MB recovery chronic phase scar size LVR. Altogether 41 patients underwent prospectively repeated cardiovascular magnetic resonance at a median 22 (interquartile range 9–29) days 10 (8–16) months after first revascularized MI. Transmural MI was defined as ≥75% enhancement in least one segment. Peak...
Aortic valve stenosis (AS) is the most prevalent valvular disease in developed countries. Four-dimensional (4D) flow cardiovascular magnetic resonance (CMR) an emerging imaging technique, which has been suggested to improve evaluation of AS severity compared two-dimensional (2D) and transthoracic echocardiography (TTE). We investigated reliability CMR 2D 4D techniques measuring aortic transvalvular peak systolic patients with severe AS. prospectively recruited 90 referred for replacement due...
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiac disease, involving changes in myocardial tissue and leading to fatal arrhythmias. Mutations desmosomal genes are thought be the main cause of ARVC. However, exact molecular genetic etiology disease still remains largely inconclusive, this along with large variabilities clinical manifestations complicate diagnostics. We report two families (n = 20) which a desmoglein-2 (DSG2) missense variant c.1003A > G,...
Background Long-term symptoms are frequent after coronavirus disease 2019 (COVID-19). We studied the prevalence of post-acute myocardial scar on cardiac magnetic resonance imaging (CMR) in patients hospitalized due to COVID-19 and its association with long-term symptoms. Materials methods In this prospective observational single-center study, 95 formerly underwent CMR at median 9 months acute COVID-19. addition, 43 control subjects were imaged. Myocardial characteristic infarction or...
Fibrosis after myocardial damage can be determined by cardiac magnetic resonance (CMR) with late gadolinium enhancement (LGE). We studied whether ventricular LGE is visible in the ventricles of pediatric and adolescent TOF (tetralogy Fallot) patients measuring investigating fibrosis correlated right volume, pulmonary regurgitation, N-terminal pro-brain natriuretic peptide (NT-proBNP) or aminoterminal propeptide type III procollagen (PIIINP). also if patient's age, post-operative follow-up...
Finnish gelsolin amyloidosis (AGel amyloidosis) is an inherited systemic with well-known ophthalmological, neurological and cutaneous symptoms. Additionally, cardiomyopathies, conduction disorders need of cardiac pacemakers occur in some patients. This study focuses on electrocardiographic (ECG) findings AGel their relation to magnetic resonance (CMR) changes. We also assessed whether ECG abnormalities were associated pacemaker implantation mortality.In this cohort study, 51 genetically...
Background: Familial dilated cardiomyopathy (DCM) is a monogenic disorder typically inherited in an autosomal dominant pattern. We have identified two Finnish families with familial that not explained by variant any previously known gene. describe the cardiac phenotype related to homozygous truncating GCOM1 variants. Methods and Results: This study included probands their relatives. All participants are of ethnicity. Whole-exome sequencing was used test probands; bi-directional Sanger...
We evaluated the capability of multichannel magnetocardiography (MCG) to detect healed myocardial infarction (MI).Multichannel MCG over frontal chest was recorded at rest in 21 patients with MI, detected by cine- and contrast-enhanced magnetic resonance imaging, 26 healthy controls. Of MI patients, 11 had non-Q wave 10 Q MIs. QRS, ST-segment, T ST-T integrals, ST-segment amplitudes, QRS field map orientations were measured.The repolarization indexes, such as ST segment separated group from...
Background Pathogenic variants in DSP associate with cardiac and cutaneous manifestations including arrhythmogenic right ventricular cardiomyopathy, dilated curly or wavy hair, palmoplantar keratoderma (PPK). Episodes of myocardial inflammation associated cardiomyopathy might be confused clinical work myocarditis other etiologies such as viral. Cardiac magnetic resonance imaging (CMR) may help differential diagnosis. Methods results This study comprised 49 Finnish patients: 34 participants...