A5032924715- Hepatitis B Virus Studies
- Hepatitis C virus research
- Congenital Heart Disease Studies
- Liver Disease Diagnosis and Treatment
- Cardiovascular Issues in Pregnancy
- Prenatal Screening and Diagnostics
- Fetal and Pediatric Neurological Disorders
- Uterine Myomas and Treatments
- Pregnancy and preeclampsia studies
- Antioxidant Activity and Oxidative Stress
- Tracheal and airway disorders
- Hepatitis Viruses Studies and Epidemiology
- Pituitary Gland Disorders and Treatments
- Aortic Disease and Treatment Approaches
- Congenital Diaphragmatic Hernia Studies
- Coronary Artery Anomalies
- Gallbladder and Bile Duct Disorders
- HIV/AIDS drug development and treatment
- Cardiac Structural Anomalies and Repair
- Minimally Invasive Surgical Techniques
- Cerebrospinal fluid and hydrocephalus
- Spinal Dysraphism and Malformations
- Lipid metabolism and biosynthesis
- Mechanical Circulatory Support Devices
- Coenzyme Q10 studies and effects
Hospital for Sick Children
2014-2023
University of Toronto
2001-2023
SickKids Foundation
2014-2023
Mount Sinai Hospital
2015-2023
Centre for Social Innovation
2020-2023
Sinai Hospital
2022
Children's National
2019
Broomfield Hospital
2012-2019
GlaxoSmithKline (India)
2019
Case Western Reserve University
2012
Abstract Background and Aim Certain hepatitis B virus (HBV) genotypes have been alleged to be associated with the development of cirrhosis hepatocellular carcinoma (HCC), response interferon therapy in Taiwanese patients. We undertook study prevalence significance HBV Indian subcontinent. Methods One hundred thirty histopathologically proven chronic HBV‐infected patients, including 52 incidentally detected asymptomatic surface antigen (HBsAg)‐positive subjects (IDAHS) infection (group I), 48...
Prenatal detection (PND) has benefits for infants with hypoplastic left heart syndrome (HLHS) and transposition of the great arteries (TGA), but associations between sociodemographic geographic factors PND have not been sufficiently explored. This study evaluated whether socioeconomic quartile (SEQ), public insurance, race ethnicity, rural residence, distance residence (distance driving time from a cardiac surgical center) are associated or timing PND, secondary aim to analyze differences...
Adiponectin is an adipokine with potent anti-inflammatory properties. However, the mechanisms by which adiponectin suppresses macrophage function are not well understood. Treatment of RAW264.7 macrophages for 18 h decreased lipopolysaccharide (LPS)-stimulated tumor necrosis factor-alpha (TNF-alpha) production. Here we demonstrate that globular (gAcrp) initially increased TNF-alpha expression in macrophages; this then contributed to interleukin-10, turn was required development tolerance...
ace and ethnicity, socioeconomic status (SES), geography have been associated with differential outcomes in congenital heart disease death.In patients hypoplastic left syndrome (HLHS), lower SES has increased complications 1-year survival. 1o previous study examined how sociodemographics affect neonatal death among prenatally diagnosed HLHS.The goal was to investigate infants a prenatal diagnosis of HLHS understand associations between maternal patient characteristics hospital discharge...
Specific mutations of the p53 tumor suppressor gene in hepatocellular carcinoma (HCC) have been reported from several parts world, but to authors' knowledge date status this has not studied HCC patients India, where is one major cancers and frequency chronic hepatitis B virus (HBV) as well C (HCV) infection exposure dietary aflatoxin B(1) very high. The most frequent mutation an AGG(Arg) AGT(Ser) missense at codon 249 exon 7.Liver biopsy specimens 21 10 healthy controls were obtained through...
The response to vaccination with recombinant hepatitis B virus (HBV) vaccine is poor in haemodialysis patients. A defect the antigen‐presenting cells may be responsible for this hyporesponsiveness. To overcome and improve HBV dialysis patients, we used granulocyte–macrophage colony‐stimulating factor (GM‐CSF) as a adjuvant. Fifteen consecutive patients chronic renal failure (CRF), commenced on dialysis, were stratified receive either 40μg (Engerix‐B) at 0, 1, 2 6 months (group A, n =9) or...
Abstract Objective The objective of this study was to compare the preoperative management and outcome neonates with duct-dependent critical CHD fetal versus postnatal diagnosis. Methods Patients referred our centre from January 1, 2009 December 31, 2010 were enrolled prospectively. Live births a form CHD, gestational age ⩾36 weeks weight ⩾2 kg at birth, intention-to-treat included in sub-study. Excluded lethal non-cardiac and/or genetic anomalies. Results In total, 129, 63 66 postnatal,...
Ultrasound assessment of the fetal anatomy and echocardiography are feasible in first trimester pregnancy. This study was designed to assess performance a comprehensive high-risk population at tertiary medicine unit.A retrospective review patients undergoing ultrasound between 11 weeks 13 + 6 gestation conducted. Findings early scan were compared with those second scan, birth outcomes or post-mortem results.Early ultrasounds performed 765 patients. The sensitivity for detecting anomalies...
Lamivudine results in the selection of resistant hepatitis B virus (HBV) variants. Because surface gene HBV overlaps completely polymerase gene, incidence and profile mutations were investigated prospectively chronic patients who on lamivudine therapy. Twenty-six with liver disease confirmed histologically included this study. Extracted DNA from sera samples subjected to PCR amplification for mutation prone regions genes genome. The emergence mutant forms biochemical derangements studied...
Household contacts of HBV-related chronic liver disease patients constitute a high-risk group for acquisition HBV infection. Some the HBsAg mutants are associated with and some reported to be transmitted vertically. There is limited information on horizontal transmission Gly 145 Arg (G145R) mutant related contacts. Its possible an unrelated third degree contact in present study. An patient; index patient, his 11 household were studied. This included four 1°, three 2°, one 3°, sexual contact....
Abstract There is limited data on the patterns of HBV mutation in family contacts chronic liver disease (CLD) patients India. DNA sequence analysis an important tool to study this viral epidemiology. Transmission and prevalence mutations S pre‐C gene region infected close HBV‐related CLD were studied. Twelve HBsAg + index their 20 studied detail. The ORF sequenced using direct PCR products. S‐gene sequencing included 32 specimens (12 cases all contacts). Pre‐C 26 14 irrespective HBeAg...
There are eight naturally occurring forms of the dietary antioxidant vitamin E. Of these, only α-tocopherol is retained at high levels in vertebrate plasma and tissues. This selectivity achieved part by action hepatic transfer protein (TTP), which facilitates selective incorporation into circulating lipoproteins. We examined effects E on TTP expression cultured hepatocytes. Treatment with precipitated a time- dose-dependent increase steady-state TTP. stabilization was caused...
<b><i>Introduction:</i></b> Antibody-mediated complete atrioventricular block (CAVB) is considered irreversible. We sought to examine the effects of transplacental steroids on fetal AV conduction. <b><i>Methods:</i></b> Fifty-nine fetuses diagnosed with CAVB at our center from 1996 2018 were reviewed. Routine dexamethasone administration birth was used limit cardiac inflammatory damage. Restoration conduction classified as “unexpected”...
Abstract Background : Nearly 14% of non‐alcoholic chronic liver disease in India is related to hepatitis B virus (HBV) and C (HCV) dual infection. There are no clear data available from the literature on therapeutic management these patients who often suffer an unfavourable course. Methods Fourteen consecutive cases biopsy‐proven fulfilling following criteria were included: Child’s A or disease, surface antigen positive, HBV‐DNA antibody HCV positive HCV‐RNA positive. Seven had (group I),...
Aorto-left ventricular tunnel (ALVT) accounts for <0.1% of congenital heart defects. Evidence on the prognosis from a fetal perspective is limited. With this retrospective international case series, we provide information outcome fetuses with ALVT.All members Association European Pediatric and Congenital Cardiology's (AEPC) working group medicine units worldwide were invited participation. We observed antenatal parameters, neonatal postnatal follow-up. Additionally, systematic search...