Paula Holinski

ORCID: 0000-0003-3341-4712
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About
Contact & Profiles
Research Areas
  • Mechanical Circulatory Support Devices
  • Cardiac Structural Anomalies and Repair
  • Congenital Heart Disease Studies
  • Cardiac Arrest and Resuscitation
  • Tracheal and airway disorders
  • Congenital Diaphragmatic Hernia Studies
  • Acute Myocardial Infarction Research
  • Heart Failure Treatment and Management
  • Cardiac Arrhythmias and Treatments
  • Esophageal and GI Pathology
  • Airway Management and Intubation Techniques
  • Sepsis Diagnosis and Treatment
  • Cardiac pacing and defibrillation studies
  • Respiratory Support and Mechanisms
  • Cardiovascular Issues in Pregnancy
  • Immune Response and Inflammation
  • Trauma, Hemostasis, Coagulopathy, Resuscitation
  • COVID-19 Clinical Research Studies
  • Bacterial Infections and Vaccines
  • Vascular Anomalies and Treatments
  • Hemodynamic Monitoring and Therapy
  • Metabolomics and Mass Spectrometry Studies
  • Cardiovascular and Diving-Related Complications
  • Cardiac electrophysiology and arrhythmias
  • Pulmonary Hypertension Research and Treatments

Stollery Children's Hospital
2016-2024

University of Alberta
2013-2024

Women's & Children's Health Research Institute
2023

Women and Children’s Health Research Institute
2023

McMaster University
2008-2009

Background Distances between delivery and cardiac services can make the care of fetuses with disease at risk acute cardiorespiratory instability birth a challenge. In 2013 we implemented fetal echocardiography‐based algorithm targeting considered high for ≤2 hours in our pediatric operating room children's hospital, and, herein, examine experience. Methods Results We reviewed maternal postnatal medical records all encountered January to March 2022 instability. Secondary analysis was...

10.1161/jaha.123.031184 article EN cc-by-nc-nd Journal of the American Heart Association 2024-03-18

To use screening cardiac troponin (cTn) measurements and electrocardiograms (ECGs) to determine the incidence of elevated cTn myocardial infarction (MI) in patients admitted intensive care unit (ICU), assess whether these findings influence prognosis. This is a prospective study. We enrolled consecutive general medical-surgical ICU over two months. All underwent systematic with ECGs on admission, then daily for first week ICU, alternate days up one month weekly thereafter until death or...

10.1186/cc6815 article EN cc-by Critical Care 2008-01-01

Pump thrombosis represents a significant cause of morbidity and mortality in patients on continuous flow ventricular assist devices (CF-VAD). the pediatric CF-VAD population has been reported between 11% 44%, with largest series from PediMACS registry reporting rate approximately 15%. We report our early experience four who developed pump CF-VAD. Our limited suggests that treatment VAD can be approached similar principles to adult population. current strategy includes:i. Initiating...

10.1097/mat.0000000000000606 article EN ASAIO Journal 2017-06-09

Congenital tracheal stenosis is an uncommon malformation that portends a poor outcome in children who are symptomatic the neonatal period. Over time, management of significant disease has been consolidated at high-volume centers, and increasingly complex patients have undergone surgical repair. We present premature newborn boy was diagnosed with critical multi-level airway cardiac decompensated remote site, requiring extracorporeal membrane oxygenation support for transport. He underwent...

10.1177/2150135117696490 article EN World Journal for Pediatric and Congenital Heart Surgery 2017-08-20

Objectives: Pediatric patients implanted with a durable ventricular assist device are initially managed in the pediatric cardiac ICU but eligible for discharge to ward. Our objectives were characterize and readmission of ICU, identify risk factors readmission, determine whether or is associated mortality. Design: Retrospective study. Setting: Stollery Children’s Hospital. Patients: Patients at less than 18 years old between 2005 2016. Interventions: None. Measurements Main Results: There 44...

10.1097/pcc.0000000000002456 article EN Pediatric Critical Care Medicine 2020-07-29

Background and aims: Delayed sepsis diagnosis in the Emergency Department (ED) or Pediatric Intensive Care Unit (PICU) is associated with adverse outcome. Metabolomics may allow for early children. Aims: Determine utility of metabolomics pediatric severe sepsis. Methods: Patients 6-17yr (systemic inflammatory response syndrome, blood culture drawn, intravenous antibiotics prescribed) requiring (n=60) not (n=38) PICU admission, non-sepsis controls (having procedural sedation, n=39) presenting...

10.1097/01.pcc.0000449371.98387.91 article EN Pediatric Critical Care Medicine 2014-05-01

Pediatric patients on ventricular assist devices (VAD) are at risk of thromboembolic (TE) complications. Our objective was to identify factors associated with TE events, including the role initial anticoagulation strategy and device type in pediatric VAD population.

10.1016/j.xjon.2024.05.007 article EN cc-by-nc-nd JTCVS Open 2024-05-01

Short-term continuous-flow ventricular assist devices (STCF-VADs) are increasingly being utilized in pediatrics. End-stage liver disease (ELD) models have been associated with outcomes adult patients on mechanical circulatory support. We sought to determine the relationship between children STCF-VADs and three ELD models: model for end-stage disease-excluding international normalized ratio (MELD-XI; all) MELD-XI (> 1 year), PELD, a novel score, PedMELD-XI. All (< 19 years) supported...

10.1097/mat.0000000000001078 article EN ASAIO Journal 2019-09-25

ABSTRACT Background Distances between delivery centers and cardiac services can make the care of fetuses with disease(CD) at risk acute cardiorespiratory instability(ACRI) birth a challenge. In 2013 we implemented fetal echocardiography(FE)-based algorithm targeting considered high-risk for ACRI ≤2 hours Caesarian section(CS) in our pediatric operating room(PCOR) children’s hospital. We examine experience outcomes affected newborns. Methods reviewed maternal postnatal medical records all CD...

10.1101/2023.03.13.23287237 preprint EN medRxiv (Cold Spring Harbor Laboratory) 2023-03-21

Background: Pediatric patients on ventricular assist device (VAD) support are at risk of thromboembolic (TE) complications which include pump thrombosis, ischemic stroke, and transient attack. Methods: We conducted a retrospective chart review pediatric implanted with Paracorporeal Pulsatile (PP) or Continuous (PC) VADs between 2005-2022, the Stollery Children's Hospital (Edmonton, AB). Patients that transitioned from PC to PP were classified in combination group. Patient related factors,...

10.1097/01.mat.0000943668.04254.09 article EN ASAIO Journal 2023-06-01

Congenital malformations of the trachea are rare but often life-threatening. Limited data have been published on outcomes tracheal reconstruction for congenital stenosis. We sought to describe patients undergoing over 10 years at our centre.

10.1016/j.cjcpc.2023.10.003 article EN cc-by CJC Pediatric and Congenital Heart Disease 2023-10-13
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