Go for gold: As-prepared insulin–Au nanoclusters (NCs) show intense red fluorescence, excellent biocompatibility, and preservation of natural insulin bioactivity in lowering the blood-glucose level. Their versatility applications is demonstrated by fluorescence imaging, X-ray computed tomography, insulin–inhibitor interactions (see picture; IDE=insulin-degrading enzyme).

Stevioside is a natural plant glycoside isolated from the Stevia rebaudiana which has been commercialized as sweetener in Japan for more than 20 years. Previous animal studies have shown that stevioside an antihypertensive effect. This study was to designed evaluate effect of human hypertension.

The antihyperglycemic action of andrographolide, an active principle in the leaves Andrographis paniculata (Burm. f.) Nees, was investigated streptozotocin-induced diabetic rats (STZ-diabetic rats). Oral treatment andrographolide decreased plasma glucose concentrations STZ-diabetic a dose-dependent manner. Similar with also normal and maximal effect more marked than that rats. Andrographolide at effective dose (1.5 mg/kg) significantly attenuated increase induced by intravenous challenge...

The antihyperglycemic action of puerarin, purified from the roots Pueraria lobata, was investigated in streptozotocin-induced diabetic rats (STZ-diabetic rats). Bolus intravenous injection puerarin decreased plasma glucose concentrations a dose-dependent manner STZ-diabetic rats. Similar treatment with also normal rats, although effect not as great that Puerarin at effective dose (15.0 mg/kg) significantly attenuated increase induced by an challenge test In isolated soleus muscle enhanced...

Sinapic acid is a hydroxycinnamic contained in plants. In an attempt to know the hyperglycemic effect of sinapic acid, this study applied streptozotocin (STZ) induce type 1-like diabetic rats and fed fructose-rich chow 2-like rats. dose-dependently reduced hyperglycemia STZ-diabetic (9.8 ± 1.8%, 11.6 0.7%, 19.4 3.2% at 5 mg/kg, 10 25 respectively). Also, attenuated postprandial plasma glucose without changing insulin Repeated treatment increased gene expression GLUT4 soleus muscle Moreover,...

The antihyperglycemic effect of caffeic acid, one the phenolic compounds contained in fruit Xanthium strumarium, was investigated. After an intravenous injection acid into diabetic rats both streptozotocin-induced and insulin-resistant models, a dose-dependent decrease plasma glucose observed. However, similar not produced normal rats. An insulin-independent action can thus be considered. Otherwise, this compound reduced elevation level receiving challenge test. Also, uptake isolated...

We have studied the effects of stevioside on glucose and insulin metabolism in 2 models diabetes rats, STZ-induced diabetic rats NIDDM induced by feeding with fructose. Stevioside (0.5 mg/kg), lowered blood levels peaking at 90 min. administered twice daily also demonstrated dose-dependent lowering both rat models. reduced rise during tolerance testing normal rats. dose-dependently decreased protein phosphoenol pyruvate carboxykinase (PEPCK) PEPCK mRNA after 15 days treatment. resistance...

To better understand the insulin-independent plasma glucose–lowering action of metformin, we used streptozotocin (STZ)-induced diabetic rats to investigate possible mechanisms. Oral intake metformin decreased glucose STZ-induced with a parallel increase β-endorphin–like immunoreactivity (BER). Mediation opioid μ-receptors in was identified by blockade receptors antagonist and failure μ-receptor knockout mice. Release BER from adrenal glands characterized, using bilateral adrenalectomy...

Paeoniflorin and 8-debenzoylpaeoniflorin were isolated from the dried root of Paeonia lactiflora Pall. (Ranunculaceae). They produced a significant blood sugar lowering effect in streptozotocin-treated rats had maximum at 25 min after treatment. This hypoglycemic action was also observed normoglycemic only 1 mg/kg. The antihyperglycemic activity seems lower than that paeoniflorin. Plasma insulin not changed paeoniflorin-treated indicating an insulin-independent action. Also, this glucoside...

Low levels of melatonin in circulation had been reported to be related the development diabetes. Melatonin administration animals increases hepatic glycogen content lower blood glucose. However, signaling pathway for these effects is still unclear. The present study shows that intraperitoneal injection 10 mg/kg ameliorated glucose utilization and insulin sensitivity high fat diet-induced diabetic mice with an increase improvement liver steatosis. We used HepG2 cells investigate pathways...

Catalpol is one of the active principles from roots Rehmannia glutinosa Steud (Scrophulariaceae) that widely used to treat diabetic disorders in Chinese traditional medicine using name Di-Huang, which investigate mechanisms for lowering plasma glucose streptozotocin-induced rats (STZ-diabetic rats). decreased a dose-related manner, and this action was reduced by pretreatment with naloxone or naloxonazine. An increase β-endorphin catalpol also observed parallel. The deleted bilateral...

BACKGROUND: The underlying mechanism of exercise on the development diabetes-associated neuropathic pain is not well understood. We investigated in rats whether regulates functional recovery and heat shock protein 72 (Hsp72), tumor necrosis factor (TNF)-α, interleukin (IL)-6 expression streptozotocin (STZ)-induced diabetes. METHODS: Male Wistar were divided into 4 groups: normal sedentary rats, with exercise, STZ-diabetic (SS) exercise. Diabetes was induced STZ (65 mg/kg IV). trained ran...

Ginsenoside Rh2 (Rh2) is an active principal ingredient contained in ginseng (Panax Meyer), a medicinal herb used to enhance health worldwide. The present study designed investigate the effect of on myocardial fibrosis diabetic rats. In streptozotocin-induced model type-1 rats (STZ-diabetic rats), increased fasting blood glucose levels and heart weight/body weight (HW/BW) ratio were substantially alleviated by Rh2. Moreover, improved cardiac performance STZ-diabetic Histological results from...

The effect of tramadol on the plasma glucose level streptozotocin (STZ)-induced diabetic rats was investigated. A dose-dependent lowering seen in fasting STZ-induced 30 min after intravenous injection tramadol. This abolished by pretreatment with naloxone or naloxonazine at doses sufficient to block opioid μ-receptors. However, response not changed receiving p-chlorophenylalanine a dose deplete endogenous 5-hydroxytrptamine (5-HT). Therefore, mediation 5-HT this action is ruled out. In...

The antihyperglycemic action of myricetin, purified from the aerial part Abelmoschus moschatus (Malvaceae), was investigated in streptozotocin-induced diabetic rats (STZ-diabetic rats). Bolus intravenous injection myricetin decreased plasma glucose concentrations a dose-dependent manner STZ-diabetic rats. Myricetin at effective dose (1.0 mg/kg) significantly attenuated increase induced by an challenge test normal A stimulatory effect on uptake soleus muscles isolated obtained...

Guava is a plentiful fruit in Taiwan and it was taken from the plants of Psidium guajava Linn. (Myrtaceae). According to folklore Chinese Medicine, gauva useful treatment diabetes mellitus. In present study, acute i.p. with 1 g/kg guava juice produced marked hypoglycemic action normal alloxan-treated diabetic mice. Although effective duration more transient less potent than chlorpropamide metformin, blood glucose lowering effect also can be obtained by oral administration maturity-onset...

1 The aim of the present study was to clarify role ginsenoside Rh2 as active compound in Panax ginseng root for lowering plasma glucose animals. 2 Plasma assessed using oxidase method. Changes levels insulin and C-peptide were measured by ELISA commercially available kits. 3 After intravenous injection into fasting Wistar rats 60 min, (0.1–1.0 mg/kg) decreased a dose-dependent manner. In parallel with decrease glucose, increases levels, well C-peptide, observed receiving same treatment....