A5016807224- Bone and Joint Diseases
- Orthopaedic implants and arthroplasty
- Bone health and treatments
- Bone health and osteoporosis research
- Hip disorders and treatments
- Bone Metabolism and Diseases
- Total Knee Arthroplasty Outcomes
- Orthopedic Infections and Treatments
- Osteoarthritis Treatment and Mechanisms
- Hip and Femur Fractures
- Rheumatoid Arthritis Research and Therapies
- Knee injuries and reconstruction techniques
- Lower Extremity Biomechanics and Pathologies
- Bone and Dental Protein Studies
- Diabetic Foot Ulcer Assessment and Management
- Cell Adhesion Molecules Research
- Surgical Simulation and Training
- Spondyloarthritis Studies and Treatments
- Immune Response and Inflammation
- Cytokine Signaling Pathways and Interactions
- Pancreatic and Hepatic Oncology Research
- Inflammatory mediators and NSAID effects
- Hematological disorders and diagnostics
- Lipoproteins and Cardiovascular Health
- Galectins and Cancer Biology
Hokkaido University
2016-2025
University of Fukui
2021-2024
University of Fukui Hospital
2021-2024
Orthopedic One
2022
Hokkaido University of Science
2021
Hokkaido University Hospital
2018-2021
Keio University
2007-2021
University of California, San Francisco
2017-2020
Sapporo Medical University
2019
Graduate School USA
2014-2019
Abstract Siglecs are a family of sialic acid–binding immunoglobulin-like lectins that regulate the functions cells in innate and adaptive immune systems through glycan recognition. Here we show Siglec-15 regulates osteoclast development bone resorption by modulating receptor activator nuclear factor κB ligand (RANKL) signaling association with DNAX-activating protein 12 kDa (DAP12), an adaptor bearing immunoreceptor tyrosine-based activation motif (ITAM). Among known expressed myeloid...
The increased incidence of osteoarthritis (OA), particularly knee and hip OA, osteoporosis (OP), owing to population aging, have escalated the medical expense burden. Osteoarthritis is more prevalent in older women, involvement subchondral bone fragility spotlights its association with OP. Notably, insufficiency fracture (SIF) may represent a pronounced condition OA pathophysiology. This review summarizes relationship between OP, incorporating recent insights into SIF. Progressive SIF leads...
Evidence supports that daily and once-weekly administration of teriparatide, human (h)PTH(1–34), enhance bone mass in osteoporotic patients. However, it is uncertain whether different frequencies hPTH(1–34) would induce formation similarly terms quantity quality. To investigate issue, mice were subjected to PTH administration, their bones histologically examined. Frequencies 1 time/2 days, time a day, 2 4 times day. Mice allocated either control or 3 dosing regimens: 80 μg/kg per injection...
Background: The incidence of developmental dysplasia the hip (DDH) in Japanese newborns has reduced drastically following a primary prevention campaign initiated around 1972 to 1973; this perinatal education promoted maintaining hips naturally flexed-leg position. purpose present study was describe life course epidemiology osteoarthritis (OA) adolescent and adult patients assess its association with exposure for DDH. Methods: We included new OA diagnosed from January 1, 2022, December 31, at...
Abstract There is currently no therapy available for periprosthetic osteolysis, the most common cause of arthroplasty failure. Here, role AnxA1 in osteolysis and potential therapeutics were investigated. Reducing expression calvarial tissue was found to be associated with increased osteolytic lesions induced by debris implantation more severe AnxA1-defecient mice than wild-type mice. inhibits differentiation osteoclasts through suppressing NFκB signaling promoting PPAR-γ pathway....
Background/Objectives: Periprosthetic osteolysis is the primary cause of arthroplasty failure in majority patients. Mechanistically, wear debris released from articulating surfaces a prosthesis initiates local inflammation and several modes regulated cell death programs, such as ferroptosis, which represents promising therapeutic target various chronic inflammatory diseases. Thus, current study aimed at exploring potential targeting ferroptosis polyethylene-wear-debris-induced model....
Background: Developmental dysplasia of the hip (DDH) is a prevalent issue in infants, with ultrasound crucial for early detection. Existing automatic diagnostic models lack precision due to noise, but 3D technology may enhance it. This study aimed create and assess deep-learning-based model automated DDH diagnosis by using transformation on two-dimensional images. Methods: A retrospective 417 infants at risk used images, combining convolutional neural networks image processing. The images...
Abstract Osteonecrosis of the femoral head (ONFH) often leads to collapse, which makes joint preservation challenging. Although curved varus osteotomy (CVO) is an effective surgical method for in young ONFH patients, there are some cases where it cannot prevent collapse. This research aims evaluate usefulness teriparatide (TPD) bone healing and preventing collapse CVO-treated patients. retrospective study included 48 patients (56 hips) diagnosed with ONFH, categorized into three groups:...
Background Periacetabular osteotomy (PAO) treats developmental dysplasia of the hip (DDH) by reducing load on and improving joint function. Untreated DDH affects lower extremity alignment alters knee morphology, with valgus more pronounced in osteoarthritis secondary to DDH. While PAO may influence mechanics, its association subchondral bone density tibiofemoral remains unclear. Questions/purposes (1) To what degree is associated changes distribution knees patients DDH? (2) Is altered such...
Abstract Vertically aligned MoS₂ nanotube-based humidity sensors have been fabricated, and the dependence of sensing performance on electrode positions were investigated. The MoS2 nanotube arrays prepared by a coating aluminum oxide (AAO) porous substrates using decompression filtration technique. two types electrodes formed in horizontal vertical positions. It was found that response for is about 6.5 times more sensitive than positions, resulting higher sensitivity. In addition, nanotubes...
Dual-energy X-ray absorptiometry (DXA) is the standard for bone mineral density (BMD) assessment but often inaccessible to cognitively or physically impaired care home patients. Radiofrequency echographic multi-spectrometry (REMS), a portable and radiation-free alternative, enables effective BMD evaluation in this vulnerable underserved population. This cross-sectional study assessed using REMS 260 patients aged ≥ 70 years (39 males, 221 females; mean age 82.29 years) between April 2023 July...