A5045160249- Bone and Joint Diseases
- Bone health and treatments
- Bone health and osteoporosis research
- Hip disorders and treatments
- Orthopaedic implants and arthroplasty
- Bone Metabolism and Diseases
- Hip and Femur Fractures
- Total Knee Arthroplasty Outcomes
- Orthopedic Infections and Treatments
- Cytokine Signaling Pathways and Interactions
- Hematological disorders and diagnostics
- Biomarkers in Disease Mechanisms
- Bone and Dental Protein Studies
- Bone Tissue Engineering Materials
- Scoliosis diagnosis and treatment
- Seismology and Earthquake Studies
- Osteomyelitis and Bone Disorders Research
- Body Composition Measurement Techniques
- Alkaline Phosphatase Research Studies
- Osteoarthritis Treatment and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Growth Hormone and Insulin-like Growth Factors
- Alcoholism and Thiamine Deficiency
- Axon Guidance and Neuronal Signaling
- Spinal Fractures and Fixation Techniques
Hokkaido University
2019-2025
University of Dental Medicine
2022-2024
Hakodate Central General Hospital
2023-2024
Orthopedic One
2022
The increased incidence of osteoarthritis (OA), particularly knee and hip OA, osteoporosis (OP), owing to population aging, have escalated the medical expense burden. Osteoarthritis is more prevalent in older women, involvement subchondral bone fragility spotlights its association with OP. Notably, insufficiency fracture (SIF) may represent a pronounced condition OA pathophysiology. This review summarizes relationship between OP, incorporating recent insights into SIF. Progressive SIF leads...
Abstract Osteonecrosis of the femoral head (ONFH) often leads to collapse, which makes joint preservation challenging. Although curved varus osteotomy (CVO) is an effective surgical method for in young ONFH patients, there are some cases where it cannot prevent collapse. This research aims evaluate usefulness teriparatide (TPD) bone healing and preventing collapse CVO-treated patients. retrospective study included 48 patients (56 hips) diagnosed with ONFH, categorized into three groups:...
The current study aimed to evaluate bone tissue regeneration using a combination of β-tricalcium phosphate (βTCP) and phosphorylated pullulan (PPL, phosphate-rich polysaccharide polymer consisting maltotriose units). Round defects 2 mm diameter were created in the arterial center rat tibiae, which further treated with vehicle (control group), βTCP (βTCP or + PPL group) grafts. control specimens without grafts exhibited rapid formation after 1 week; however, regenerated was not resorbed until...
This study aimed to examine minimodeling-based bone formation between the epiphyses and metaphyses of long bones eldecalcitol (ELD)-administered ovariectomized rats. Sixteen-week-old female rats were divided into four groups: sham-operated receiving vehicle (Sham group), (OVX) (Vehicle or ELDs (30 90 ng/kg BW, respectively; ELD30 ELD90 groups). ELD administration increased volume trabecular thickness, reducing number osteoclasts in both OVX The Sham Vehicle groups exhibited mainly...
Abstract In this study, we investigated the relationship between head length, leg offset, and dislocation resistance using range of motion (ROM) simulations based on computed tomography data to examine if a longer femoral reduces risk dislocation. The components were set eliminate length differences with + 0 mm head, variations for 4-, 7-, 8-mm heads analyzed. Offset ROM assessed when used, adjusted be similar that contralateral side. While internal rotation at flexion external extension...
To clarify the cellular mechanism of cortical porosity induced by intermittent parathyroid hormone (PTH) administration, we examined femoral bone mice that received 40 µg/kg/day (four times a day) human PTH (hPTH) (1–34). The PTH-driven initiated from metaphyseal region and chronologically expanded toward diaphysis. Alkaline phosphatase (ALP)-positive osteoblasts in control covered surface, endomucin-positive blood vessels were distant these osteoblasts. In PTH-administered mice,...
The number of patients with fragility fracture has been increasing. Although the increasing increased rate (refracture), causes refracture are multifactorial, and its predictors still not clarified. In this issue, we collected a registry-based longitudinal dataset that contained more than 7000 fractures treated surgically to detect potential for clinical refracture. Based on fact machine learning algorithms often used analysis large-scale dataset, developed automatic prediction models...
Abstract Background There is evidence that the cause of primary osteoarthritis (OA) related to changes in subchondral bone; however, influence insufficiency fracture (SIF) femoral head on degeneration hip joint and prognostic factors remain unclear. The objectives this study were (1) investigate natural history space width after occurrence SIF (2) associations between narrowing bone metabolic markers as well magnetic resonance imaging (MRI) among patients with SIF. Methods Between January...
Given the potential fundamental function of osteal macrophages in bone pathophysiology, we study here their precise experimental osteoporosis. Gene profiling from ovariectomized mice demonstrated upregulation genes that were involved oxidative stress, cell senescence and apoptotic process. A scRNA-seq analysis revealed heterogenously clustered into 6 subsets expressed proliferative, inflammatory, anti-inflammatory efferocytosis gene signatures. Importantly, postmenopausal exhibited a 20-fold...