The fluorinated heterocycles are main components of 20% the anticancer and antibiotic drugs, this review describes reported antimicrobial activities five-membered their benzo-fused systems.

A series of novel piperazine-based bis(thiazoles) 13a-d were synthesized in moderate to good yields

A series of bis -thiazoles 5a–g were synthesized from -thiosemicarbazone 3 with hydrazonoyl chlorides 4a–g. Reaction two equivalents α-halocarbonyl compounds 6–8, 10, and 12a–d afforded the corresponding -thiazolidines 9, 11, 13a–d, respectively. Condensation -thiazolidin-4-one 9 different aromatic aldehydes furnished -thiazolidin-4-ones 14a–d. Compounds 5a–g, 13a,c,d screened in vitro for their cytotoxic activities a panel cancer cell lines. 5a–c, 5f–g, exhibited remarkable activities,...

UO 2 (II), Er (III), and La (III) complexes were prepared from new bis (amino triazole) Schiff base ligand. The ligand was synthesized by condensation of 1,3‐bis(4‐amino‐5‐phenyl‐1,2,4‐triazol‐3‐ylsulfanyl)propane with benzaldehyde. structure the compounds confirmed some spectroscopic tools such as 1 H‐NMR, UV‐Vis, IR, well molar conductance, mass spectrometry, elemental analysis, thermogravimetric analysis (TG), differential (DTG), thermal (DTA) studies. data revealed coordination...

The condensation reaction between 5‐amino‐1,3,4‐thiadiazole‐2‐thiol and 1,2‐dibromoethane to afford the ligand L was carried out in direct obtain desired organic ligand. New [Er(L)ClH 2 O]Cl ·3H O, [Yb(L)(H O) ]Cl 3 ·4H [Ta(L)Cl O complexes have been prepared from (L) by reacting one mole metal ions with L. In addition their physical characteristics, they were described using spectroscopic techniques (infrared [IR], nuclear magnetic resonance [NMR], UV–Vis), gas chromatography (GC)‐mass,...

Some heterocycles having bisamide linkage are receiving much interest due to their remarkable biological potencies and they naturally occurring. bisamides thiazole derivatives were found inhibit the protein levels of Bcl-2 significantly. This prompted us synthesize new bis(heterocyclic) function explore anti-cancer activities.Novel bis-amide-based bis-thiazoles thiadiazoles synthesized by reaction a bisthiosemicarbazone with variety hydrazonoyl chlorides, a-chloroacetylacetone haloacetic...

A series of bis(triazolothiadiazines) and bis(quinoxalines) were synthesized tested for their cytotoxicity apoptosis-induction through PARP-1 EGFR as molecular targets. Compound 8i exhibited high cytotoxic activity promising dual enzyme inhibition.

Over time, urban dwellers have become increasingly concerned with the thermal characteristics in their neighbourhood. Modern Asian cities environmental diversity introduced complexity to heat island (UHI) predictions. This research aimed discover relative contribution of different and anthropogenic parameters UHI intensity Kuala Lumpur, Malaysia. Four days temperature wind data were collected from seven sites representing various land covers inside outside city. Besides, humidity solar...

Due to the toxicity of lead(<sc>ii</sc>) all living organisms destroying central nervous system and leading circulatory brain disorders, development effective selective ionophores for its detection is very important.

Three new metal complexes of 4‐(benzylideneamino)‐5‐phenyl‐4H‐1,2,4‐triazole‐3‐thiol ligand (L) and three transition ions: Fe (III), Cu (II), Zn (II) were synthesized characterized. The derived from 4‐amino‐5‐phenyl‐1,2,4‐triazole‐3‐thiol benzaldehyde was in a 1:1 molar ratio. All the chelates characterized by elemental analysis, conductivity measurements, thermal FT‐IR, 1 H‐NMR spectroscopy. IR spectrum revealed that Schiff base coordinated neutral bidentate manner with ions through...

Many bis-1,3,4-thiadiazoles 7, 10a,b, 13a-c and bis-thiazoles 16a-d, 19a-d were synthesized from reaction of bis(hydrazonoyl) chloride 4 with a series methyl carbodithioate thiosemicarbazone derivatives. Their antimicrobial activities evaluated six selected microorganisms. Some the prepared derivatives showed higher activity than reference used. Furthermore, molecular docking most active compound 10 b site target enzymes studied using MOE 2014.010 software package.

Abstract magnified image This review covers the main strategies for synthesis of N ‐pivot lariat ethers as well their specific syntheses.

The garden-city model, characterised by sprawling urban expansion and extensive open spaces, features green water surfaces alongside substantial road networks, large parking lots unshaded lands. This diverse landscape contributes to uneven air temperature distribution within the city. Our study investigated heat island (UHI) patterns in various environments Putrajaya, focusing on rural, business, residential near-water areas. Atmospheric data were collected over a year. Putrajaya exhibits...