A5055949391- Cervical Cancer and HPV Research
- Hepatitis B Virus Studies
- Suicide and Self-Harm Studies
- Genital Health and Disease
- Global Cancer Incidence and Screening
- COVID-19 and healthcare impacts
- MicroRNA in disease regulation
- Health disparities and outcomes
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Vaccine Coverage and Hesitancy
- Circular RNAs in diseases
- Reproductive tract infections research
- COVID-19 and Mental Health
- Herpesvirus Infections and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- RNA Research and Splicing
- Molecular Biology Techniques and Applications
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Cancer-related Molecular Pathways
- Cancer Immunotherapy and Biomarkers
- Data-Driven Disease Surveillance
- Workplace Health and Well-being
- Homicide, Infanticide, and Child Abuse
Hokkaido University
2015-2025
University of Aberdeen
2023-2024
Sapporo University
2021-2023
Asahikawa Medical University
2021-2023
Health Sciences University of Hokkaido
2022
University hospital Medical Information Network
2022
Japanese Red Cross Medical Center
2022
Shibuya (Japan)
2022
Takasaki University of Health and Welfare
2022
Creative Commons
2022
BackgroundFunding for human papillomavirus (HPV) vaccination in Japan began 2010 girls aged 12–16 years, with three-dose coverage initially reaching more than 70%. On June 14, 2013, 2 months after formal inclusion Japan's national immunisation programme, proactive recommendations the HPV vaccine were suspended following reports of adverse events since found to be unrelated vaccination, but which extensively covered media. Vaccine subsequently dropped less 1% and has remained this low date....
// Yosuke Konno 1,* , Peixin Dong 2,* Ying Xiong 3,* Fumihiko Suzuki 4,* Jiabin Lu 5 Muyan Cai Hidemichi Watari 1 Takashi Mitamura Masayoshi Hosaka Sharon J. B. Hanley 2 Masataka Kudo and Noriaki Sakuragi 1,2 Department of Gynecology, Hokkaido University, Sapporo, Japan Women's Health Educational System, 3 State Key Laboratory Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China 4 Obstetrics Tohoku Sendai, Pathology, * These authors contributed equally to...
In June 2013 the Japanese Ministry of Health, Labor, and Welfare (MHLW) suspended its HPV vaccination recommendation after a series highly publicized alleged adverse events following immunization stoked public doubts about vaccine's safety. This paper examines global spread news Japan's vaccine suspension through online media, takes retrospective look at non-Japanese media sources that were used to support those claiming injury in Japan. Methods: Two searches conducted. One searched relevant...
In ovarian cancer (OC) cells, Snail was reported to induce the epithelial-to-mesenchymal transition (EMT), which is a critical step in OC metastasis. At present little known about controlling expression cells by using specific microRNAs (miRNAs). We first used computational target prediction analysis identify 6 candidate miRNAs that bind 3′-untranslated region (3′-UTR) of mRNA. Among these miRNAs, two (miR-137 and miR-34a) with potential regulate were validated quantitative real-time PCR,...
PD-L1, a key inhibitory immune receptor, has crucial functions in cancer evasion, but whether PD-L1 promotes the malignant properties of cervical (CC) cells and mechanism by which is regulated CC remains unclear. We report that overexpressed CC, shRNA-mediated depletion suppresses proliferation, invasion, tumorigenesis cells. Loss miR-140/142/340/383 contributes to upregulation. miR-18a enhances levels targeting PTEN, WNK2 (ERK1/2 pathway inhibitor), SOX6 (Wnt/β-catenin inhibitor p53...
The COVID-19 pandemic is negatively impacting mental health globally. While increased social cohesion may have initially decreased suicide risk, there are few reports on the long-term impact. We examined impact of by gender and age through December 2021 in Japan.We analyzed trends monthly rates from January 2016 to using provisional mortality data an interrupted time series analysis. also considered linear pre-pandemic period seasonal variations. Pandemic onset was defined as April 2020....
EZH2 inhibition and reactivation of tumor suppressor microRNAs (miRNAs) represent attractive anti-cancer therapeutic strategies. We found that EZH2-suppressed let 7b miR-361, two likely suppressors, inhibited endometrial cancer (EC) cell proliferation invasion, abrogated stem cell-like properties. In EC cells, induced functioned together with YY1 to epigenetically suppress which upregulated Twist, a direct target miR-361. Treating cells GSK343, specific inhibitor, mimicked the effects...
The Human Papillomavirus Prevention and Control Board brought together experts to discuss optimizing HPV vaccination screening programs. members reviewed the safety profile of licensed vaccines based on clinical post-marketing data, reaching a consensus that current data is reassuring. Successful programs used well-coordinated communication campaigns, integrating (social) media spread awareness. Communication evidence supporting vaccine effectiveness had beneficial effects perception...
Proactive recommendations for human papillomavirus (HPV) vaccines in Japan have been suspended 5 years because of safety concerns. While no scientific evidence exists to substantiate these concerns, one reason given not reinstating is the lack reliable vaccine effectiveness (VE) data a Japanese population. This study reports VE bivalent HPV women aged 20-22 years.During cervical screening between 2014 and 2016, had Papanicolaou smears tests performed provided about their sexual history....
Overexpression of IQGAP1 and microRNA (miRNA) dysregulation are frequent in human tumors, but little is known about the role its relationship to miRNA endometrial carcinogenesis. We demonstrate that activates epithelial-mesenchymal transition (EMT) program miR-124 directly represses expression cancer (EC) cells. The overexpression stimulates EMT features enhances migration, invasion proliferation EC cells, whereas knocking down reverses inhibits these malignant properties. Using microarray...
Although previous studies have shown promise for targeting Musashi RNA-binding protein 2 (MSI-2) in diverse tumors, the role and mechanism of MSI-2 cervical cancer (CC) progression regulation expression remains unclear. Using gene bioinformatic analysis, together with gain- loss-of-function assays, we identified as a novel oncogenic driver poor prognostic marker CC. We explored c-FOS by via RNA-immunoprecipitation luciferase assay, confirmed direct inhibition miR-143/miR-107 using assay....
Although the oncogene MMSET (also known as NSD2 or WHSC1) has an essential role in malignancies, its impact on human endometrial cancer (EC) metastasis and molecular mechanism of regulation are largely unknown. We report that was markedly upregulated EC cell lines tissues, significantly associated with poor survival EC. overexpression greatly promoted invasion sphere formation, whereas inhibition reduced formation. Importantly, Twist1 required for MMSET-induced Moreover, we demonstrate...
The Human Papillomavirus (HPV) Prevention and Control Board convened a meeting in Bucharest, Romania (May 2018), to discuss the role of healthcare providers (HCPs) prevention programs, with focus on HPV vaccination cervical cancer screening. International local experts discussed that HCPs can play increase uptake vaccine Experts recommended: 1) increasing HCP norms getting vaccinated; 2) training make effective recommendations; 3) making culturally appropriate materials available, languages;...
In Japan, recommendations for HPV vaccines were suspended in 2013 due to unfounded safety fears. Although vaccine opponents claim modifying sexual behavior can prevent cervical cancer, no comprehensive data exist on and the risk of high-grade disease a Japanese population. This study investigates infection 3968 women aged 20-41 yrs undergoing screening between April 2014 March 2016. Mean age at first intercourse was 18.4 ± 2.8 32% reported ≥ 6 lifetime partners. regression analyses, number...
The charcoal burning suicide epidemics in both Hong Kong and Taiwan have been well documented. However, little is known about the situation Japan.To examine impact of on overall other method-specific rates between 1998 2007 Japan.Using data obtained from Vital Statistics Japan, negative binomial regression analyses were performed to investigate method.In males females aged 15-24 25-44 years, epidemic led a substantial increase suicides, without decrease methods. In all age groups, no such...
Japan has no national vaccine registry and approximately 1700 municipalities manage the immunization records independently. In June 2013, proactive recommendations for human papillomavirus (HPV) were suspended after unconfirmed reports of adverse events following in media, despite safety signal having been raised. Furthermore, studies assessing HPV effectiveness published post suspension are predominantly based on self-reported information. Our aim was to examine accuracy vaccination status...