A5074506701- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cerebrovascular and Carotid Artery Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Peripheral Artery Disease Management
- Cardiac Valve Diseases and Treatments
- Cardiovascular Disease and Adiposity
- Cardiovascular Function and Risk Factors
- Cardiac and Coronary Surgery Techniques
- Cardiac Arrhythmias and Treatments
- Mechanical Circulatory Support Devices
- Lipoproteins and Cardiovascular Health
- Advanced X-ray and CT Imaging
- Cardiac pacing and defibrillation studies
- Cardiac Structural Anomalies and Repair
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Issues in Pregnancy
- Aortic aneurysm repair treatments
- Cardiac electrophysiology and arrhythmias
- Surgical Simulation and Training
- Anatomy and Medical Technology
- Ultrasound and Hyperthermia Applications
- Atherosclerosis and Cardiovascular Diseases
Ollscoil na Gaillimhe – University of Galway
2022-2025
Shizuoka City Hospital
2014-2025
University Hospital Galway
2023
National University of Ireland
2023
University Medical Center Groningen
2015
Zentralklinik Bad Berka
2015
Perm State Medical Academy
2015
Abstract Background and Aims In patients with three-vessel disease and/or left main disease, selecting revascularization strategy based on coronary computed tomography angiography (CCTA) has a high level of virtual agreement treatment decisions invasive (ICA). Methods this study, artery bypass grafting (CABG) procedures were planned CCTA without knowledge ICA. The CABG was recommended by central core laboratory assessing the anatomy functionality circulation. primary feasibility endpoint...
P2Y12 inhibitor monotherapy without aspirin immediately after percutaneous coronary intervention (PCI) has not been tested in East Asian patients, so this study we aimed to assess the safety and feasibility of reduced dose (3.75 mg/day) prasugrel Japanese patients presenting with chronic syndrome (CCS).
Diffuse coronary artery disease (CAD) impacts the immediate hemodynamic and clinical outcomes of percutaneous intervention (PCI). We evaluated whether diffuse pattern CAD derived from angiographic Quantitative flow ratio (QFR) outcome post-PCI medium term predicted vessel-oriented composite endpoint (VOCE). Paired pre-procedure QFRs were assessed in 503 patients 1022 vessels Multivessel TALENT (MVT) trial. The pathophysiological was defined as "predominantly diffuse" or "focal" according to...
Wall shear stress (WSS) estimated in models reconstructed from intravascular imaging and 3-dimensional-quantitative coronary angiography (3D-QCA) data provides important prognostic information enables identification of high-risk lesions. However, these analyses are time-consuming require expertise, limiting WSS adoption clinical practice. Recently, a novel software has been developed for real-time computation time-averaged (TAWSS) multidirectional distribution. This study aims to examine its...
The very long-term mortality of off-pump and on-pump coronary artery bypass grafting (CABG) versus percutaneous intervention (PCI) in a randomized complex disease population is unknown. This study aims to investigate the impact CABG PCI on 10-year all-cause mortality.The SYNTAX trial 1800 patients with three-vessel and/or left main or assessed their survival at 10 years. In this sub-study, hazard over years was compared according technique revascularization: (n = 725), 128) 903).There...
The geographical disparity in the pathophysiological pattern of coronary artery disease (CAD) among patients undergoing percutaneous intervention (PCI) is unknown.
Abstract Aims Risk stratification and individual risk prediction play a key role in making treatment decisions patients with complex coronary artery disease (CAD). The aim of this study was to assess whether machine learning (ML) algorithms can improve discriminative ability identify unsuspected, but potentially important, factors the long-term mortality following percutaneous intervention or bypass grafting CAD. Methods results To predict mortality, ML algorisms were applied SYNTAXES...
This study evaluated the relationship between pre-PCI pathophysiological patterns of CAD assessed by QFR, intracoronary imaging findings, and their impact on immediate physiological outcomes after PCI in 206 patients.
Many attempts have been made to inhibit or counteract saphenous vein graft (SVG) failure modes; however, only external support for SVGs has gained momentum in clinical utility. This study revealed the feasibility of implantation, and showed good patency out 12 months novel biorestorative graft, a challenging ovine coronary artery bypass model. finding could trigger first-in-man trial using material instead SVG. We believe that, eventually, this can be one options patients who difficulty harvesting
Abstract The outcomes from real-life clinical studies regarding the optimal revascularization strategy in patients with multivessel coronary artery disease (MVD) are still poorly investigated. In this retrospective study we assessed 5-year outcomes: primary, secondary endpoints and quality of life 1035 individuals severe (CAD) treated either bypass grafting (CABG)—356 or percutaneous intervention (PCI)—679 according to recommendation a local Heart Team (HT). At 5 years no significant...
Background Hypertrophic cardiomyopathy (HCM) is often concomitant with sleep-disordered breathing (SDB), which can cause adverse cardiovascular events. Although an appropriate approach to SDB prevents cardiac remodelling, detection of in patients HCM remains suboptimal. Thus, we aimed develop a machine learning-based discriminant model for HCM. Methods In the present multicentre study, consecutively registered and performed nocturnal oximetry. The outcome was high Oxygen Desaturation Index...
Abstract Murray law-based quantitative flow ratio (µQFR) assesses fractional reserve (FFR) in bifurcation lesions using a single angiographic view, enhancing the feasibility of analysis; however, accuracy may be compromised suboptimal projections. FFR CT is well-validated non-invasive method measuring from coronary computed tomographic angiography (CCTA). We evaluated µQFR left main (LM) bifurcations, impact optimal/suboptimal fluoroscopic view with respect to CCTA, and its diagnostic...
Since the initial attempt to adapt anatomical SYNTAX score (aSS) coronary computed tomography angiography (CCTA), CCTA imaging technology has evolved, and is currently used as a "decision-maker" for revascularization strategy in complex artery disease (CAD) rendered necessary some updating of aSS modality.
Personalized long term vital prognosis plays a key role in deciding between percutaneous coronary intervention (PCI) and CABG patients with complex artery disease. The FASTTRACK trial enrolls the sole guidance of computed tomographic angiography (CCTA) fractional flow reserve CCTA (FFRCT). feasibility/non-feasibility this approach is determined by surgeon request to have access invasive angiography.This interim analysis, which was requested Data Safety Monitoring Board (DSMB), compared...
The impact of reduced left ventricular ejection fraction (LVEF) on very long-term prognosis following percutaneous coronary intervention (PCI) or artery bypass graft (CABG) has been debated. aim this study was to investigate the LVEF at baseline 10-year mortality in SYNTAX trial.Patients (n = 1800) were categorized into three sub-groups: (rEF ≤ 40 %), mildly (mrEF 41-49 and preserved (pEF ≥ 50 %). score 2020 (SS-2020) applied patients with LVEF<50 % %.Ten-year mortalities 44.0 %, 31.8 22.6...