A5101554767- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Renal Diseases and Glomerulopathies
- Coronary Interventions and Diagnostics
- Autoimmune Bullous Skin Diseases
- Effects of Radiation Exposure
- Platelet Disorders and Treatments
- Vasculitis and related conditions
- Dialysis and Renal Disease Management
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Cancer-related Molecular Pathways
- Antiplatelet Therapy and Cardiovascular Diseases
- Heart Rate Variability and Autonomic Control
- Cardiovascular Syncope and Autonomic Disorders
- Genomics and Chromatin Dynamics
- Cardiovascular Effects of Exercise
- Cardiovascular Issues in Pregnancy
- Chronic Kidney Disease and Diabetes
- Cardiac, Anesthesia and Surgical Outcomes
- Lymphoma Diagnosis and Treatment
- Cancer Cells and Metastasis
- DNA Repair Mechanisms
Hamamatsu Medical Center
2007-2025
Juntendo University Nerima Hospital
2020-2025
Juntendo University
2012-2025
Juntendo University Urayasu Hospital
2024
Nagoya University
2005-2022
Nagoya Medical Center
2019
University of Leicester
2017-2019
Aichi Prefectural Cardiovascular Respiratory Disease Center
2003-2008
National Institutes for Quantum Science and Technology
1998
The TNF family member a proliferation-inducing ligand (APRIL; also known as TNFSF13), produced by myeloid cells, participates in the generation and survival of antibody-producing plasma cells. We studied potential role APRIL pathogenesis IgA nephropathy (IgAN). found that significant proportion germinal centers (GCs) tonsils patients with IgAN contained cells aberrantly producing APRIL, contributing to an overall upregulation tonsillar expression compared control tonsillitis. In GC,...
Intravascular ultrasound (IVUS) was only rarely used in landmark trials comparing percutaneous coronary intervention (PCI) with artery bypass grafting (CABG) patients multivessel disease.The authors aimed to evaluate clinical outcomes after optimal IVUS-guided PCI undergoing PCI.The OPTIVUS (OPTimal IntraVascular UltraSound)-Complex study cohort a prospective multicenter single-arm enrolling 1,021 PCI, including left anterior descending using IVUS, aiming meet the prespecified criteria...
Targeted-release budesonide modifies key pathogenic biomarkers inimmunoglobulin A nephropathy: Insights from the NEFIGAN trial Biomarkers with significant changes baseline at 9 months Nefecon 16 mg/d CONCLUSION exerts a direct disease-modifying effect in IgAN by targeting GALT, regulating mucosal immune dysfunction and potentially modulating systemic response
A 75-year-old woman who underwent percutaneous coronary intervention using an everolimus-eluting stent showed silent in-stent occlusion. Pathological examination of the neointima, resected through directional atherectomy, revealed a double-layered neointima with neointimal hyperplasia and thrombus. Stent-edge restenosis subsequent thrombosis, related to clopidogrel resistance, likely caused thrombotic
ABSTRACT Atypical hemolytic uremic syndrome is a thrombotic microangiopathy caused by the abnormal activation of alternative complement pathway. Mutations in complement‐related genes and autoantibodies against regulators are involved pathogenesis this condition; frequency of, prognosis patients harbouring, each genetic mutation varies based on region race. Complement factor I ( CFI ) mutations have been observed 4%–8% cases Europe; however, they not yet reported Japan. We present first...
Expression of novel NP95 (nuclear protein, 95 kDa), which contains a leucine zipper motif, zinc finger putative cyclin A/E-cyclin-dependent protein kinase 2 phosphorylation site, and retinoblastoma protein-binding motifs, is associated with S-phase progression mouse cells. It suppressed during G1 G2/M phases in normal thymocytes but expressed at constantly high level irrespective cell stage T lymphoma was shown previously to be strongly only proliferative tissues In this immunohistochemical...
l-carnitine is an important factor in fatty acid metabolism, and carnitine deficiency common dialysis patients. This study evaluated whether supplementation improved muscle spasm, cardiac function, renal anemia Eighty Japanese outpatients (62 hemodialysis (HD) patients 18 peritoneal (PD) patients) received oral (600 mg/day) for 12 months; the HD further intravenous injections (1000 mg three times/week) months, amounting to 24 months of treatment. Muscle spasm incidence was assessed using a...
There is a scarcity of data evaluating contemporary real-world dual antiplatelet therapy (DAPT) strategies after percutaneous coronary intervention (PCI).
Vagal denervation during pulmonary vein isolation (PVI) may reduce paroxysmal atrial fibrillation (PAF) recurrences. Valid predictors of late PAF recurrence after PVI were examined.Successful segmental (S-PVI) or circumferential (C-PVI) was achieved in 120 consecutive patients. The 24-h Holter recordings obtained before and PVI. Logistic regression analysis performed to determine independent among the patient characteristics, technique heart rate variability (HRV). Of patients, 19 excluded...