A5012213409- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Platelet Disorders and Treatments
- Autoimmune Bullous Skin Diseases
- Systemic Sclerosis and Related Diseases
- Health disparities and outcomes
- Health and Wellbeing Research
- Systemic Lupus Erythematosus Research
- Pediatric Urology and Nephrology Studies
- Cardiovascular Health and Risk Factors
- Blood groups and transfusion
- COVID-19 and healthcare impacts
- Data-Driven Disease Surveillance
- Monoclonal and Polyclonal Antibodies Research
- Celiac Disease Research and Management
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Mobile Health and mHealth Applications
- Dialysis and Renal Disease Management
- Employment and Welfare Studies
- Abdominal vascular conditions and treatments
- Complement system in diseases
- Health, psychology, and well-being
- Bladder and Urothelial Cancer Treatments
- Muscle and Compartmental Disorders
- Health, Environment, Cognitive Aging
Kitasato University
2023-2025
Juntendo University
2011-2024
Ministry of Health Labour and Welfare
2021-2024
Japanese Society of Nephrology
2021-2024
Kyoto University
2013-2023
Suzuka University of Medical Science
2020
Saiseikai Utsunomiya hospital
2010
<h3>Importance</h3> Although IgA nephropathy (IgAN) is the most common glomerulonephritis in world, there no validated tool to predict disease progression. This limits patient-specific risk stratification and treatment decisions, clinical trial recruitment, biomarker validation. <h3>Objective</h3> To derive externally validate a prediction model for progression IgAN that can be applied at time of kidney biopsy multiple ethnic groups worldwide. <h3>Design, Setting, Participants</h3> We...
<h3>Importance</h3> Immunoglobulin A nephropathy is a major cause of end-stage renal disease worldwide; previous methods medical management, including use renin-angiotensin system inhibitors and corticosteroids, remain unproven in clinical trials. <h3>Objective</h3> To investigate the possible association between tonsillectomy outcomes patients with IgA nephropathy. <h3>Design, Setting, Participants</h3> This cohort study included 1065 enrolled 2002 2004 divided into 2 groups, those who...
The International IgA Nephropathy (IgAN) Prediction Tool is the preferred method in 2021 KDIGO guidelines to predict, at time of kidney biopsy, risk a 50% drop estimated glomerular filtration rate or failure. However, it not known if can be accurately applied after period observation post-biopsy. Using an international multi-ethnic derivation cohort 2,507 adults with IgAN, we updated for use one year and externally validated this 722 adults. original one-year without modification had...
Background Recent studies have shown that galactose-deficient IgA1 (GdIgA1) has an important role in the pathogenesis of IgA nephropathy (IgAN). Although emerging data suggest serum GdIgA1 can be a useful non-invasive IgAN biomarker, localization nephritogenic GdIgA1-producing B cells remains unclear. clinical and experimental indicate immune activation tonsillar toll-like receptor (TLR) 9 may involved IgAN. Here we assessed possibility production palatine tonsils patients. Methods We...
Background As a counter-cluster measure to prevent the spread of infectious novel coronavirus disease (COVID-19), an efficient system for health observation outside hospital is urgently required. Personal records (PHRs) are suitable daily management physical conditions. Importantly, there no major differences between items collected by via PHR and related COVID-19. Until now, observations COVID-19 have been performed exclusively based on disease-specific items. Therefore, we hypothesize that...
Background On the basis of findings observational studies and a meta-analysis, proteinuria reduction has been proposed as surrogate outcome in IgA nephropathy. How long needs to be maintained mitigate long-term risk disease progression is unknown. Methods In this retrospective multiethnic cohort adult patients with nephropathy, we defined remission ≥25% from peak value after biopsy, an absolute <1 g/d. The exposure interest was total duration first remission, treated time-varying...
Recent clinical reports indicate a correlation between gross hematuria after the coronavirus 2019 (COVID-19) vaccination in patients with glomerulonephritis, especially immunoglobulin A nephropathy (IgAN). Furthermore, healthcare workers Japan were initially vaccinated an mRNA vaccine from February 17, 2021, and some of them experienced receiving vaccination.We conducted web-based survey councilor members Japanese Society Nephrology (581 members, 382 facilities) to elucidate relationship...
Research was limited on demographic and work-related characteristic of general workplace loneliness. The present descriptive cross-sectional study aimed to know correlates loneliness in a working population Japan. We recruited 25,000 persons aged 20 years old or older employed by company, organization, government agency. the sample only employees for this analysis. Demographic characteristics were assessed self-report questionnaire. General measured single-item questions dichotomized. A...
Abstract Background Depressive disorders in University students have risen dramatically the past few decades to extent that students’ mental health has become a current global public priority. Obtaining information from about their is challenging because of potential embarrassment disclosing one’s concerns and fear stigmatization. Self-rated might be good solution evaluate state by simple neutral indicator. The aim study investigate association between depressive symptoms self-rated sex...
Key Points Little is known about the clinicopathological characteristics and renal outcomes in patients with gross hematuria (GH) after vaccination. To fill a knowledge gap regarding vaccination GH, we conducted nationwide multicenter prospective cohort study. GH more likely to occur IgA nephropathy, female bias, but without progressive exacerbation of function. Background In past 3 years, cases for coronavirus disease 2019 nephropathy (IgAN) have been frequently reported worldwide. However,...
We require a clinicopathological risk stratification method for immunoglobulin A nephropathy (IgAN) to predict kidney outcomes. examined renal failure group (RF-RG) classification system created following prior multicentre, retrospective study determine if RF-RG could collected data from Japanese patients with IgAN registered between 1 April 2005 and 31 August 2015. The primary outcome was composite 50% increase in serum creatinine baseline or dialysis induction. secondary outcomes were...
Efficacy of systemic corticosteroid therapy (CS) for long-term kidney survival in patients with IgA nephropathy (IgAN) is controversial. Therefore, prospective studies evaluating targeted therapies to lymphatic tissues mucosal immune system responsible production nephritogenic have been desired worldwide. Here, we aimed evaluate the associations CS and combination tonsillectomy (CS + Tx) survival, using database from a nationwide multicenter cohort study on IgAN. Primary outcome was 50%...
Abstract Background Clinical factors affecting renal prognosis in patients with immunoglobulin A nephropathy (IgAN) and low urinary protein excretion (U-Prot) remain unclear. This study evaluated such clinical grade I (CG-I) IgAN U-Prot < 0.5 g/day. Methods secondary analysis of a previous retrospective included 394 CG-I IgAN. The primary outcome was the first occurrence 1.5-fold increase serum creatinine levels from baseline. Factors related to were examined using univariate multivariate...
Chronic kidney disease (CKD) management requires a multidisciplinary approach. Although several treatment targets exist, the relationships between number of clinical criteria and CKD progression have not been studied. Here, we investigated association renal dysfunction parameters. We retrospectively enrolled 373 patients with mild impaired function indicated by serum creatinine level > 2.0 mg/dL measured in 2012. assessed parameters both 2009 2012, analyzed whether each parameter (e.g.,...