A5115604029- Dialysis and Renal Disease Management
- Central Venous Catheters and Hemodialysis
- Vascular Procedures and Complications
- Tissue Engineering and Regenerative Medicine
- Gastrointestinal motility and disorders
- Vitamin C and Antioxidants Research
- Burn Injury Management and Outcomes
- Uterine Myomas and Treatments
- Radioactivity and Radon Measurements
- Metabolism and Genetic Disorders
- Rabies epidemiology and control
- Cardiac tumors and thrombi
- Parathyroid Disorders and Treatments
- Ovarian cancer diagnosis and treatment
- Diabetes Treatment and Management
- Radiation Dose and Imaging
- Mesenchymal stem cell research
- Intraperitoneal and Appendiceal Malignancies
- Sodium Intake and Health
- Iron Metabolism and Disorders
- Ovarian function and disorders
- Dermatological diseases and infestations
- Blood Pressure and Hypertension Studies
- Social Media in Health Education
- Radiation Therapy and Dosimetry
Juntendo University
2010-2020
Tokyo Metropolitan Geriatric Hospital
2015
Radiation Protection Institute
2006
l-carnitine is an important factor in fatty acid metabolism, and carnitine deficiency common dialysis patients. This study evaluated whether supplementation improved muscle spasm, cardiac function, renal anemia Eighty Japanese outpatients (62 hemodialysis (HD) patients 18 peritoneal (PD) patients) received oral (600 mg/day) for 12 months; the HD further intravenous injections (1000 mg three times/week) months, amounting to 24 months of treatment. Muscle spasm incidence was assessed using a...
While pruritus is a common complication in hemodialysis patients, the pathophysiological mechanisms remain obscure. Recently, B-type (brain) natriuretic peptide (BNP) has been defined as an itch-selective neuropeptide pruriceptive neurons mice, and higher serum levels of BNP are frequently observed patients. The objective present study was to evaluate role patients undergoing hemodialysis.The current cross-sectional performed on 43 maintenance hemodialysis. A visual analog scale (VAS)...
High glucose concentrations influence the functional and structural development of peritoneal membrane. We previously reported that oral administration astaxanthin (AST) suppressed fibrosis (PF) as well inhibited oxidative stress, inflammation, epithelial-mesenchymal transition (EMT) mesothelial cells (PMCs) in a chlorhexidine-induced PF rat model. This suggests stress induction EMT is key event during damage. The present study evaluated therapeutic effect AST suppressing EMT, response to...
It is well known that a combination therapy with peritoneal dialysis (PD) and hemodialysis (HD) feasible may improve clinical status in patients for whom adequate solute fluid removal difficult to achieve PD alone. The objective of the present study was evaluate whether useful likelihood long-term membrane cardiac function. 6 days one session HD per week. Physical, biochemical, dialysate-to-plasma ratio creatinine (D/P Cr), arteriovenous fistula (AVF) blood flow, left ventricular mass index...
Preventing peritoneal damage during dialysis is critical. Reactive oxygen species (ROS) have an important role in damage; however, few studies investigated this. We aimed to determine the effects of oral astaxanthin (AST) supplementation a fibrosis (PF) rat model.Thirty-seven Sprague-Dawley rats were divided into 5 groups: Control 1 (fed normal diet without stimulation), 2 AST-supplemented Group with 8% chlorhexidine gluconate [CG] stimulation for 3 weeks), 0.06% CG and that was initiated 4...
BackgroundThe prevention and restoration of peritoneal damage is a critical mission in dialysis (PD). Transplantation mesothelial cells has been suggested to suppress injury during PD. Few studies have examined the efficacy safety cell transplantation. We evaluated paracrine effects transplantation repair using immortalized temperature-sensitive (TSMCs) chlorhexidine gluconate (CG)-induced fibrosis rats.
Although ultrasonography before a vascular access (VA) operation has become popular in recent years, benchmarks for the diameter or blood flow of arteries veins are not defined Japan. The objective present study is to analyze relationship between preoperative US findings and patency rate VA Japanese hemodialysis patients. 139 patients with end stage kidney disease were enrolled this study. They had been given primary radiocephalic arteriovenous fistula (AVF) from February 2009 December 2010...
Abstract Peritoneal dialysis ( PD ) catheters often become severely dislocated, which may lead to malfunction. With the aim of preventing this complication, we have developed a simple method fixing catheter downwards in peritoneal cavity (fixation technique), technique that does not require laparoscope. Sixteen patients were implanted using conventional placement and 25 fixation technique. The location tip was classified from grade 1 (downward, normal) 5 (dislocated). frequency dislocation...
Abstract Laparoscopic findings have been used to confirm peritoneal degenerations in dialysis (PD) therapy. This study evaluated morphological changes the peritoneum and their clinical relevance patients undergoing PD. at rectovesical were scored using an imaging system time of PD catheter removal this multicenter study. Angiogenesis by vascular score (VS), color (CCS), plaque (PS), duration, history peritonitis, dialysate/plasma creatinine (D/P Cr) levels, age termination statistically...
We report herein an adult case of chronic kidney disease (CKD) associated with diabetes. The patient had been treated insulin injection for diabetes 10 years ago. At the time his first visit to our division further examinations, we diagnosed him as CKD: cause (C) diabetes; glomerular filtration rate (GFR) (G) G5 (estimated [e] GFR, 10.2 mL/min/1.73 m2; serum creatinine 4.90 mg/dL); and albuminuria (A) A3 (2.62 g/gCr) by Japanese Society Nephrology (JSN) CGA classification. Because he...
Purpose: To find detectable cytogenetic biomarkers that can offer information about the radiation quality of in vivo exposure retrospectively.Materials and methods: Chromosome-type aberrations peripheral lymphocytes uterine cancer patients received internal γ- external X-ray therapy or carbon beam victims severely exposed to neutrons γ-rays a criticality accident occurred Tokai-mura, Japan were analysed. Data obtained from vitro irradiation experiments using 60Co 10 MeV compared with...
Roxadustat is one of the oral hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) that stimulates erythropoiesis and regulates genes related to iron metabolism. The treatment HIF-PHIs useful compared with erythropoietin stimulating agent (ESA) using various instruments procedures. Few clinical researchers have examined efficacy safety switching from Darbepoetin in Japanese hemodialysis (HD) patients. However, severe adverse drug reactions, such as thrombotic events. In present...
For patients with a prolonged menstrual cycle who do not respond to clomiphene citrate, the drug can be administered again at higher dose during another cycle. Clomiphene citrate should administrated two five days after start of menstruation; however, enhanced ovulation effects may occur as potential adverse reaction high-dose therapy, which limits its use. Furthermore, ovulatory-phase timing administration differs between normal and those This indicates does directly act on ovulatory phase....
Objective:
症例は48歳, 男性. 糖尿病性腎症による末期腎不全で, 平成2X年4月上旬に血液透析 (HD) を導入された. 導入直後より39°C台の発熱を認めたが原因不明で, 抗生物質による改善より細菌性感染と考えた. 以後, 近医でHDを施行していたが, 8月下旬に嘔吐があり腹部腫瘤を指摘され, 再度精査加療の目的で入院となった. 画像検査上, 腹腔内小腸周囲に12×5×8cmの被膜を有する囊胞性腫瘤を認めた. 手術所見は腹膜の癒着と臓側・壁側腹膜に充実性腫瘤を多数認め, 腫瘤自体は癒着が強く切除不能であった. 進行性の悪性軟部腫瘍と考えられたが, 他臓器の病変は認めなかった. 病理組織所見では, 高度の好中球・マクロファージの浸潤, 巨細胞状の多核細胞を散見し核の多形性を認めた. 免疫染色では, 特異的マーカーは陰性であった. 以上より, 炎症性悪性線維性組織球腫と診断された. 透析症例における本疾患については既報がなく, 貴重な症例と考え報告する.
目的: 血管中膜石灰化は慢性腎臓病 (chronic kidney disease;CKD) 患者に特徴的な合併症であり, 心血管系イベントや死亡率を増加させる原因となっている. CKD患者の貧血の治療に使用される鉄 (Fe) は, 酸化ストレスを増悪させ血管内皮障害を惹起する作用を有するとされている. 一方でin vitroの研究では, フェリチンが血管平滑筋の骨芽細胞への形質転換を抑制することで, 血管へのCa沈着を抑制し石灰化を予防するとの報告がある. 今回, われわれはアデニン食で腎不全ラットを作製し, 尿毒症状態におけるFeの血管石灰化に対する効果について検討した. 対象動物: 10週齢の雄のSprague-Dawley (SD) ラット24匹を用いた. 方法: 24匹のSDラットを4群 ( (1) 対照群, (2) 対照群+Fe投与群, (3) 尿毒症群, (4) 尿毒症+Fe投与群に分けた. アデニン食 (0.75%アデニン含有食) 投与により尿毒症・石灰化モデルラットを作製し, それぞれの石灰化の程度, ナトリウム依存性リン酸輸送体...
症例は54歳，女性．平成3年，IgA腎症による慢性腎不全のため腹膜透析（PD）を施行し，平成12年から血液透析（HD）を併用した．平成19年6月，PDカテーテルを抜去した．その直後から腹水の貯留を認めるようになり，被嚢性腹膜硬化症（EPS）を疑い副腎皮質ステロイド内服治療を行ったが，腹水は改善しなかった．平成20年2月，腹痛と血圧低下で緊急入院し，腹水穿刺でゼリー状の貯留液を認めた．直ちに腹部MRIを行ったところ，左卵巣腫瘍の腫大と腹腔内に多量の腹水を認め，卵巣腫瘍と腹膜炎を疑い緊急手術となった．開腹所見では，左卵巣の腫大と多数の大腸憩室，腹腔に充満したゼリー状内容物を認め，回盲部周囲の内容物は混濁していた．病理組織所見から左卵巣の粘液性嚢胞性腫瘍の穿破による腹膜偽粘液腫と憩室炎による腹膜炎と診断された．PD中止後の腹水貯留に対して，体液過剰やEPSのみならず，稀ではあるが粘液や漿液産生腫瘍などの発症も考慮し，病態の検索が必要であると考えられた．
【目的】血液透析患者の低亜鉛血症に伴う貧血に対する亜鉛補充療法の投与基準がいまだ確立されていないことから, 本療法の有用性と投与方法について検討した. 【対象・方法】エリスロポエチン9,000U/週以上の投与で血清亜鉛値79μg/dL以下の血液透析患者 (33名) に亜鉛45～50mg/日を3か月間補充投与した. 【結果】血清亜鉛値は, 開始時57.9±9.71μg/dLであったが, 3か月後は92.4±24.2μg/dLと有意に改善した (p<0.0001). しかし, 血清銅値の低下が23名に認められた. 赤血球造血刺激因子製剤低反応性指数は, 開始時23.1±15.9U/week/kg/Hb (g/dL) であったが, 3か月後は12.4±6.1U/week/kg/Hb と有意な改善がみられた (p=0.0002). 【結語】血液透析患者における貧血の管理に亜鉛補充療法は有用である. 本療法は短期間であっても低銅血症のリスクが高く注意が必要である.