A5056341808- Parathyroid Disorders and Treatments
- Dialysis and Renal Disease Management
- Renal Transplantation Outcomes and Treatments
- Genetic Syndromes and Imprinting
- Renal Diseases and Glomerulopathies
- Bone health and treatments
- Magnesium in Health and Disease
- Vitamin D Research Studies
- Muscle and Compartmental Disorders
- Ion Transport and Channel Regulation
- Electrolyte and hormonal disorders
- Pharmacological Effects and Toxicity Studies
- Potassium and Related Disorders
- Bone health and osteoporosis research
- Renal and Vascular Pathologies
- Metabolism, Diabetes, and Cancer
- COVID-19 Clinical Research Studies
- Bone and Joint Diseases
- Neurological Complications and Syndromes
- Medical Imaging and Pathology Studies
- Renal function and acid-base balance
- SARS-CoV-2 and COVID-19 Research
- Amino Acid Enzymes and Metabolism
- Biomedical Research and Pathophysiology
- Organ Transplantation Techniques and Outcomes
Jikei University School of Medicine
2016-2025
Hypertension Institute
2009-2016
Tokushima University
1998-2003
Growth is critically dependent on the retention of a variety nutrients. The kidney contributes to this positive external balance. In present study, we isolated cDNA from human and rat that encodes growth-related Na(+)-dependent inorganic phosphate (P(i)) cotransporter (type IIc). Microinjection type IIc cRNA into Xenopus oocytes demonstrated sodium-dependent P(i) cotransport activity. Affinity for was 0.07 mm in 100 Na(+). transport activity extracellular pH. electrophysiological studies,...
The TGF-β superfamily comprises pleiotropic cytokines that regulate SMAD and non-SMAD signaling. TGF-β–SMAD signal transduction is known to be involved in tissue fibrosis, including renal fibrosis. Here, we found 1,25-dihydroxyvitamin D3–bound [1,25(OH)2D3-bound] vitamin D receptor (VDR) specifically inhibits through direct interaction with SMAD3. In mouse models of 1,25(OH)2D3 treatment prevented fibrosis the suppression transduction. Based on structure VDR-ligand complex, generated 2...
Magnesium concentration is a proven predictor of mortality in hemodialysis patients. Recent reports have indicated that proton pump inhibitor (PPI) use affects serum magnesium levels, however few studies investigated the relationship between PPI and levels This study aimed to clarify association We designed this cross sectional included 1189 patients stable condition. Associations magnesium-related factors, as well other possible confounders, were evaluated using multiple regression model....
Denosumab, a fully human anti-RANKL monoclonal antibody, is widely used osteoporosis treatment that increasingly being in patients undergoing dialysis; however, its long-term efficacy and safety these remain unknown.
The role of parathyroid gland (PTG) ultrasonography in the management secondary hyperparathyroidism after introduction calcimimetics remains unclear. Recent investigations have prompted renewed interest use PTG for assessing treatment resistance to and determining optimal timing surgical intervention. This study aimed explore hypothesis that volume correlates with calcimimetic dose. We retrospectively observed outpatients undergoing haemodialysis at baseline a 4-year follow-up. was measured...
Abstract The challenge of managing acute hypercalcemia in patients diagnosed with malignancy (HCM) merits further attention. Elevated levels PTHrP may be a risk factor for treatment resistance hypercalcemia; however, few studies have tested this hypothesis. This study aimed to investigate whether high represent an independent that impedes the hypercalcemia. retrospective cohort recruited 159 aged 20-80 years malignancies who had been hospitalized above reference value (1.1 pmol/L). median...
Glial cells missing homolog 2 (GCM2), a zinc finger-type transcription factor, is essential for the development of parathyroid glands. It considered to be master regulator because glands do not form when Gcm2 deficient. Remarkably, expression maintained throughout fetal stage and after birth. Considering function in embryonic stages, it predicted that maintains cell differentiation survival adults. However, there lack research regarding adulthood. Therefore, we analyzed adult...
The extracellular domain of klotho is cleaved and released into various fluids, such as blood, urine, cerebrospinal fluid, soluble α-klotho (sαKl).We measured sαKl in 53 hemodialysis patients 20 healthy controls to examine its role mineral metabolism.The level the was 430 pg/ml (386 - 540 pg/ml, which lower than that 740 (550 913 p < 0.01). serum showed a positive correlation with phosphorus (P) (σ = 0.33, 0.014), while corrected Ca tended be negatively correlated -0.26, 0.06). Both...
Infectious diseases are the second highest cause of death in patients on dialysis. In addition, testosterone deficiency or hypogonadism is prevalent dialysis patients. However, to our knowledge, no studies have investigated association between levels and infectious events. We aimed evaluate whether serum associated with infection-related hospitalization male hemodialysis a prospective cohort study.We divided study population into 3 groups based levels. Associations clinical outcomes...
Fibroblast growth factor 23 (FGF23) is associated with cardiovascular disease and all-cause mortality in patients diabetes mellitus. Insulin resistance has recently been reported to increase FGF23 levels, resistin a peptide that mainly regulates insulin resistance. However, few studies have investigated the association between resistin. A total of 422 mellitus were recruited for this cross-sectional study examine intact FGF23. The mean ( ± standard deviation) age was 63.1 11.9 years, median...
Treatment with PTH (parathyroid hormone) or a high-P(i) diet causes internalization of the type IIa sodium-dependent phosphate (Na/P(i) IIa) co-transporter from apical membrane and its degradation in lysosome. A dibasic amino acid motif (KR) third intracellular loop is essential for protein's PTH-induced retrieval. To elucidate mechanism Na/P(i) IIa, we identified interacting protein endocytic by yeast two-hybrid screening. We found strong interaction small known as PEX19 (human peroxisomal...
In patients with chronic kidney disease (CKD), coronary artery calcification occurs at two distinct sites in the vessel wall: intima and media. Arterial media (AMC), a nonocclusive condition, affects hemodynamics differently compared to arterial (AIC), which atherosclerotic plaques. is considered cell-regulated process resembling intramembranous bone formation. The purpose of this retrospective observational study was clarify morphological differences between AIC AMC evaluate role vascular...
Background We aimed to examine associations among serum 25-hydroxyvitamin D (25OHD) levels, 1,25-dihyroxyvitamin (1,25OHD) vitamin receptor (VDR) polymorphisms, and renal function based on estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes. Methods In a cross-sectional study of 410 patients, chronic kidney disease (CKD) stage assessed by eGFR was compared 25OHD, 1,25OHD, VDR FokI (rs10735810) polymorphisms an ordered logistic regression model adjusted for the...
Background. Recurrence of IgA nephropathy (IgAN) in the transplanted kidney is associated with graft survival, but no specific treatment available. Tonsillectomy (TE) reportedly arrests progression IgAN native kidney. Thus, we conducted a single-centre retrospective cohort study to evaluate effect TE prior recurrence. Methods. Of 36 patients biopsy-proven who underwent transplantation, 27 were included this study. Nine at 1 year after transplantation (group 1), and remaining 18 did not...
Abstract We report a case of plasma cell‐rich rejection accompanied by acute antibody‐mediated in patient with ABO ‐incompatible kidney transplantation. A 33‐year‐old man was admitted for an episode biopsy; he had serum creatinine ( S ‐ C r) level 5.7 mg/dL 1 year following primary Histological features included two distinct entities: (1) focal, aggressive tubulointerstitial inflammatory cell (predominantly cells) infiltration moderate tubulitis; and (2) (including neutrophils) peritubular...
Abstract Aim Encapsulating peritoneal sclerosis (EPS) is a rare but serious complication that occurs in dialysis (PD) therapy. The present study aimed to identify the risk factors, especially peritonitis and biocompatible PD fluid. Methods included 703 patients who received between January 1980 March 2015 at two centres. were divided into groups: those had developed EPS (EPS group: n = 44) no documentary evidence of (non‐EPS 659). independent risks determined by univariate multivariate...
Patients with chronic kidney disease (CKD) present high mortality and morbidity rates despite the availability of various therapies. Although CKD-mineral bone disorder (MBD) renal anemia are important factors in patients CKD, only few studies have analyzed relationship between them. Therefore, this study aimed to evaluate CKD-MBD CKD who did not receive erythropoiesis-stimulating agent or iron therapies.This retrospective cross-sectional included aged ≥ 20 years estimated glomerular...
<i>Background/Aim:</i> Recent research has shown that transplanted metanephroi form primitive vascularized kidneys with histologically recognizable renal features. The aim of the present study was to determine metabolic function in rats chronic failure (CRF), particular reference secondary hyperparathyroidism and vascular calcification. <i>Methods:</i> CRF induced 11-week-old male Wistar by maintaining them on a 0.75% adenine diet for 4 weeks, followed normal an...
Background Several reports on patients with diabetes mellitus (DM) treated by peritoneal dialysis (PD) have shown a higher risk of PD-associated peritonitis compared to non-DM (NDM) patients. The aim this study was investigate the incidence in DM Methods We divided all who received PD at single center between January 1980 and December 2012 into three groups according era: Period 1 (n = 43, 1980–1993); 2 123, 1994–2004); 3 207, 2005–2012). investigated incidences without DM. Results In...