A5013634568- Renal Transplantation Outcomes and Treatments
- Renal Diseases and Glomerulopathies
- Organ Transplantation Techniques and Outcomes
- Immune Cell Function and Interaction
- Platelet Disorders and Treatments
- Neurological Complications and Syndromes
- Renal and Vascular Pathologies
- Vasculitis and related conditions
- Transplantation: Methods and Outcomes
- Organ Donation and Transplantation
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Polyomavirus and related diseases
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Complement system in diseases
- Cytomegalovirus and herpesvirus research
- RNA Interference and Gene Delivery
- Abdominal vascular conditions and treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Pregnancy and Medication Impact
- Mast cells and histamine
- Genetics and Neurodevelopmental Disorders
- Organ and Tissue Transplantation Research
- Nephrotoxicity and Medicinal Plants
- Lipid metabolism and disorders
Jikei University School of Medicine
2015-2023
Tokyo Women's Medical University
2018-2022
Iwate University
2017
Hypertension Institute
2016
Prophylaxis of antibody-mediated rejection (AMR) caused by donor-specific antibodies remains challenging. Given the critical roles complement activity in graft injury, we developed a lipid nanoparticle (LNP) formulation small-interfering RNA against C5 (C5 siRNA-LNP) and investigated whether siRNA-LNP could downregulate act as an effective treatment for AMR.Lewis recipient rats were sensitized skin grafting from Brown Norway donor rats. Kidney transplantation was performed at 4 wk post-skin...
Background. Recurrence of IgA nephropathy (IgAN) in the transplanted kidney is associated with graft survival, but no specific treatment available. Tonsillectomy (TE) reportedly arrests progression IgAN native kidney. Thus, we conducted a single-centre retrospective cohort study to evaluate effect TE prior recurrence. Methods. Of 36 patients biopsy-proven who underwent transplantation, 27 were included this study. Nine at 1 year after transplantation (group 1), and remaining 18 did not...
The mortality rate due to COVID-19 in kidney transplant recipients (KTRs) is 16.8 32%. Vaccination against expected contribute the prevention of infection, severe disease, and mortality; however, it has been reported that humoral response acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccine KTRs poor. strategies vary from country country, Japan, third dose given 6 months after second dose. Few studies have evaluated long-term responses SARS-CoV-2 vaccine. In addition,...
Both immunological and non-immunological etiologies affect graft function after kidney transplantation, including acute rejection, calcineurin inhibitor toxicity, a recurrence of glomerulonephritis. Glomerular enlargement or glomerular sclerosis due to hyperfiltration related increased renal blood flow is another cause. Although the volume in baseline biopsies predicts late allograft function, relationship between annual changes transplantation are unclear.We investigated their...
Previous studies have shown that a donor/recipient body weight mismatch affects long-term graft survival and function after kidney transplantation. However, the mechanisms are not fully understood.To address mechanisms, we compared pathological physiological features between patients with those without 1 yr Furthermore, investigated correlation ratio.We examined allograft biopsy specimens from 10 recipients stable function, (donor/recipient ratio [D/R BWR] < 0.9), them samples 13 mismatch....
We report a case of recurrent Henoch-Schönlein purpura nephritis (HSPN) treated successfully with tonsillectomy and steroid pulse therapy in kidney transplant patient. A 29-year-old woman was admitted to our hospital for an episode biopsy; she had serum creatinine (S-Cr) 1.0 mg/dL 1.34 g/day proteinuria 26 months after transplantation. Histological examination revealed increased amounts mesangial matrix hypercellularity IgA deposition. Of note, one glomerulus showed focal endocapillary...
The low sensitivity of C4d immunoreactivity in peritubular capillaries (PTCs) hinders its use the diagnosis chronic active antibody-mediated rejection (CAAMR). C4d-negative CAAMR was defined 2013 Banff classification, which included expression endothelial-associated transcripts (ENDATs). We previously showed that ENDAT caveolin-1 (CAV-1) is a distinct feature CAAMR. In this study, we investigated prognostic value CAV-1 PTCs kidney transplant patients. Ninety-eight recipients were study....
Plasma cell-rich acute rejection (PCAR) is a rare type of in renal transplantation. Despite aggressive immunotherapy, approximately 40-60% patients develop graft loss within 1 year after an episode PCAR. However, the reason for this outcome remains obscure. This study retrospectively identified six with PCAR diagnosed between 2009 and 2015 at single university hospital. Clinicopathological data were collected. Five male, mean age onset was 49.0 ±14.5 years. None showed overall poor adherence...
A 56-year-old man who had undergone cadaveric kidney transplantation 21 months earlier was admitted to our hospital for a protocol biopsy; he serum creatinine level of 1.2 mg/dL and no proteinuria. Histological features showed two distinct entities: (i) inflammatory cell infiltration, in the glomerular peritubular capillaries (ii) focal, aggressive tubulointerstitial predominantly plasma cells, with mild tubulitis (Banff 13 classification: i2, t1, g2, ptc2, v0, ci1, ct1, cg0, cv0)....
Helicobacter cinaedi causes bacteremia and cellulitis, mainly in immunocompromised patients. We report a rare case of H. with cellulitis living-donor kidney transplant recipient identified by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). A 54-year-old Asian man IgA nephropathy underwent transplantation 14 years previously. He was admitted to our hospital for evaluation fever multifocal cellulitis. isolated from the patient's blood using gyrase...
Both prevention and treatment of recurrent immunoglobulin A nephropathy (IgAN) in kidney transplant recipients are important since IgAN seems to affect long-term graft survival. We present here a case that was successfully treated using steroid pulse therapy plus tonsillectomy 10 years after transplantation. 46-year-old male admitted for an episode biopsy with serum creatinine level 1.8 mg/dl proteinuria (0.7 g/day). Histological features showed (only focal segmental mesangial proliferation)...
Patients with Alport syndrome (AS) develop progressive kidney dysfunction due to a hereditary type IV collagen deficiency. Survival of the allograft in patients AS is reportedly excellent because does not recur. However, several studies have implied that GBM originates from podocytes recruited recipient's bone marrow-derived cells, suggesting possibility recurrence. Limited data are available regarding recurrence and graft survival Japanese population; vast majority were obtained living...
Herein, we report a case of antibody-mediated rejection (ABMR) due to anti-HLA-DQ antibody after pregnancy and delivery in female kidney transplant recipient. A 34-year-old recipient was admitted at 2 years for an examination elevated serum creatinine (S-Cr) level. The patient had received living transplantation from her mother 22 age, graft function almost stable. episode biopsy showed peritubular capillaritis capillaropathy with C4d immunoreactivity the capillaries. Additional revealed...
Transplantation outcomes are affected by the increase in rejection associated with ischemia reperfusion injury (IRI). Fractalkine (FKN), a chemokine for recruitment of CX3CR1+ leukocytes, contributes to pathogenesis various inflammatory diseases. Herein, we evaluated importance FKN-CX3CR1 axis during IRI-related rejections using mouse heterotopic heart transplantation model. FKN expression and graft survival was compared between wild-type C57BL/6 recipients transplanted BALB/c hearts...
Abstract Background Lipoprotein glomerulopathy (LPG) is a apolipoprotein E (ApoE)-related glomerular disease and has been associated with type III hyperlipidemia. Without appropriate treatment, chronic kidney (CKD) caused by LPG progresses, approximately half of the patients develop end-stage within 1–27 years onset. However, few studies have highlighted clinical course cardiovascular diseases (CVDs) in LPG. Herein, we report first case which CVD risk was assessed using arterial stiffness....
Despite the recent development of immunosuppressive agents, plasma cell-rich acute rejection (PCAR) has remained refractory to treatment. Herein, we report an unusual case PCAR that responded well pulse steroid therapy alone. A 47-year-old man was admitted for a protocol biopsy three months after kidney transplantation, with stable serum creatinine level 1.6 mg/dL. Histological examination showed focal aggressive tubulointerstitial inflammatory cell infiltration predominantly polyclonal...
Posttransplant anemia (PTA) is associated with the progression of kidney disease and mortality in transplant recipients. Although main causes PTA are recipient factors, donor factors have not been fully investigated. In this study we investigated association pathological findings incidence recipients after 3 years transplantation. We conducted a retrospective cohort at single university hospital. A total 50 consecutive adult donors were enrolled. To assess structure interstitial lesions,...
We report a case of graft intolerance syndrome in which transplant nephrectomy was performed 11 years after kidney transplantation. A 46-year-old man admitted to our hospital February 2018 with mild fever, left lower abdominal pain, and gross hematuria enlargement the transplanted kidney. Urinary tract infection ruled out. Because symptoms developed immunosuppressants had been stopped loss, suspected. He lost his 2016 all since January 2017. Immunosuppressive therapy intensified, steroid...