A5012938435- Renal Diseases and Glomerulopathies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Complement system in diseases
- Urticaria and Related Conditions
- Mast cells and histamine
- Dialysis and Renal Disease Management
- Systemic Lupus Erythematosus Research
- Autoimmune Bullous Skin Diseases
- Chronic Kidney Disease and Diabetes
- Vasculitis and related conditions
- Peptidase Inhibition and Analysis
- Hemophilia Treatment and Research
- Vitamin K Research Studies
- Muscle metabolism and nutrition
- Diet and metabolism studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Adipose Tissue and Metabolism
- Diabetes Management and Research
- Platelet Disorders and Treatments
- Diabetes Management and Education
- Blood groups and transfusion
- Erythropoietin and Anemia Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiovascular and exercise physiology
Juntendo University
2014-2024
Soka Municipal Hospital
2016-2024
Chiba University Hospital
2023
Chiba University
2023
Saitama Prefecture
2016-2019
Nagoya University
1998-2015
Aichi Gakuin University
2007-2014
Juntendo University Hospital
2013
Directorate-General for Interpretation
2009
The University of Tokyo
2007
Abstract Background Glomerular damage in IgA nephropathy (IgAN) is mediated by complement activation via the alternative and lectin pathways. Therefore, we focused on molecules stabilizing regulating pathway C3 convertase urine which might be associated with IgAN pathogenesis. Methods Membrane attack complex (MAC), properdin (P), factor H (fH) Complement receptor type 1 (CR1) were quantified samples from 71 patients 72 healthy controls. deposition of C5, fH P was assessed using an...
Podocalyxin (PCX) is present on the apical cell membrane of podocytes and shed in urine from injured podocytes. Urinary podocalyxin (u-PCX) associated with severity active glomerular injury patients diseases. This study examined relationship between number urinary podocytes, levels u-PCX, adults IgA nephropathy (IgAN).Urine samples voided morning day biopsy were obtained 51 IgAN (18 men 33 women; mean age, 31 years). All renal specimens analyzed histologically. Pathologic variables per...
The objective of the present study was to elucidate association between glomerular complement depositions belonging alternative (AP) and lectin (LP) pathways, clinical findings lupus nephritis (LN). Immunofluorescence (IF) performed on 17 LN patients using antibodies against factor B, H, properdin, mannose-binding (MBL) L-ficolin. Compared with B/factor H negative ( n = 9), positive 8) showed longer duration p < 0.05) more severe interstitial fibrosis 0.05). Eleven had properdin...
Abstract Relatively high circulating levels of soluble tumor necrosis factor (TNF) receptors (TNFRs: TNFR1, TNFR2) have been associated with not only progression to end-stage renal disease but also mortality in patients diabetes. It remains unknown whether elevated TNFR haemodialysis are mortality. We studied 319 receiving maintenance who were followed for a median 53 months. Circulating markers TNF pathway (TNFα and TNFRs) measured immunoassay. Strong positive correlations between TNFR1...
GA2LEN, the Global Allergy and Asthma European Network, HAE international (HAEi), global umbrella organization for world's hereditary angioedema (HAE) patient groups, have launched their joint ACARE (Angioedema Center of Reference Excellence) program, within GA2LEN's center reference excellence (CORE) initiative. Angioedema is a common, heterogeneous, often debilitating chronic condition frequently challenge physicians affected patients, especially patients suffering from recurrent attacks....
With no approved treatments in Japan for the prevention of hereditary angioedema (HAE) attacks, there is a significant unmet need long-term prophylactic therapies Japanese patients with HAE. Berotralstat (BCX7353) an oral, once-daily, highly selective inhibitor plasma kallikrein development prophylaxis attacks HAE patients.APeX-J phase 3, randomized, double-blind, placebo-controlled, parallel-group, 3-part trial conducted (University Hospital Medical Information Network identifier,...
The pathogenic roles of glomerular deposition components the complement cascade in IgA nephropathy (IgAN) are not completely clarified. To investigate pathologic role pathways IgAN, two IgAN-prone mouse models were examined. Grouped ddY (gddY) mice showed significant high proteinuria, severe lesions, and extracellular matrix expansion compared with serum (HIGA) but similar intensity deposition. Glomerular activation classical, lectin, alternative was demonstrated by significantly stronger...
The composition of the gut microbiome is altered in patients with chronic kidney disease (CKD). Dysbiosis leads to decreased levels stool organic acids (OAs) and systemic inflammation, followed by accumulation uremic toxins (UTs) development end-stage (ESKD). We assessed relationship between UT or ESKD comparing undergoing hemodialysis (HD) those normal renal function (NRF). This cross-sectional study recruited 41 HD 38 sex- age-matched NRF, microbiome, plasma UTs, inflammatory markers, OAs...
The purpose of this study was to examine the influences long-term walking training and jumping on bone mineral density (BMD) metabolism. Data from 28 healthy premenopausal women assessed. subjects were divided into group (WG; 17 mean+/-SE age 35+/-2 years), (WJG; 11 39+/-1 years). BMD measured in lumbar spine proximal femur using dual energy X-ray absorptiometry (DXA). As markers metabolism, measure formation markers, bone-alkaline phosphatase (B-ALP: by enzyme immunoassay/EIA) osteocalcin...
The rate at which patients are accurately diagnosed with hereditary angioedema (HAE), as well access to modern treatments differs greatly among countries. Moreover, the severity and burden of HAE on have been reported mostly basis physician-reported surveys. To gain insight into real-world conditions through a patient-reported survey in Japan identify any unmet needs.A questionnaire was distributed 121 via Japanese patient organization during 2016-2017. Responses were collected from 70...
Abstract IgA nephropathy (IgAN) is the most common form of chronic glomerulonephritis. Although glomerular deposition complement components well known, evidence serological activation in IgAN inconclusive. We hypothesized that serum levels and regulatory proteins patients with are correlated its pathogenesis. In present study we measured 50 healthy volunteers. C5, C1 inhibitor, factor B, C4 binding protein, H, I were use single radial immunodiffusion. Mannose‐binding lectin (MBL) properdin...
Abstract Several clinical markers correlate well with the diagnosis and prognosis of IgA nephropathy (IgAN). In present study, we re‐evaluated usefulness these four for prediction patients IgAN through a comparison between many more those other types renal diseases. 364 289 disease were examined. An analysis was performed prior to biopsy, using including, serum IgA, IgA/C3 ratio, number red blood cells in urinary sediments, protein. Patients divided into groups according histopathological...
This guideline was provided by the Japanese Association for Complement Research targeting clinicians making an accurate diagnosis of hereditary angioedema (HAE), and prompt treatment HAE patient in Japan. is a 2010 year version will be updated according to any pertinent medical advancements.
Abstract Background The diagnosis of hereditary angioedema (HAE) is often delayed due to the low awareness this condition. In patients with undiagnosed HAE, abdominal symptoms create risk unnecessary surgical operation and/or drug therapy. To explore cause misdiagnosis, we compared laboratory findings HAE under normal conditions those during attacks. Methods Patient medical histories were analyzed and data at first consultation no medication visits emergency department severe Results...
Background The impact of being overweight remains unclear in Asian populations that tend to be lean. objective this study is clarify the body mass index (BMI) and metabolic factors on prognosis Japanese patients with IgA nephropathy (IgAN). Methods A total 193 IgAN were divided into three groups equally according BMI: Group L (lean group, 15.6–20.1 kg/m 2 ), M (middle 20.2–23.0 O (obesity 23.1–31.9 ). Clinical data at time renal biopsy progression after analyzed. Results At biopsy,...
Hereditary angioedema (HAE) is a rare but life-threatening condition that results from mutations in C1-inhibitor (C1-INH). Since distinguishing HAE other causes of (AE) critical problem emergencies, the objective present study was to clarify differences between and forms AE.Seventy-two patients with AE were enrolled this study. The medical history laboratory data at first visit compared those types AE.Subjects included 23 HAE, 33 mast cell-mediated AE, 5 drug-induced 11 idiopathic AE....
Abstract Hereditary angioedema ( HAE ), caused by inherited deficiency of C1 esterase inhibitor (C1‐ INH is characterized recurring subcutaneous and/or submucosal edema. Although its efficacy remains controversial, tranexamic acid TXA ) used to treat in some countries. We analyzed as an on‐demand and prophylactic treatment patients with . Published data were systematically sourced from PubMed Embase. All retained articles underwent grading/bias assessment using the “ SIGN ” grading system,...
Background Anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (AAGN) is the fulminant glomerular diseases with poor renal prognosis. Activation of complement system has recently been reported in pathogenesis AAGN, but it remains to be clarified as which pathway mainly involved.Methods 20 patients myeloperoxidase (MPO)-AAGN were retrospectively evaluated. Using serum samples, circulating immune-complexes (CICs) assessed by monoclonal rheumatoid factor assay, and C5a...
A known inhibitor of the complement cascade (K-76 COONa) was administered to an inbred diabetic rat model investigate whether system may play a role in progression glomerulosclerosis. Drinking water containing K-76 COONa available continuously rats (Otsuka Long-Evans Tokushima Fatty, OLETF) from age 25 55 weeks (Group L). without similarly OLETF H) and nondiabetic control (Long-Evans Otsuka, LETO) C). The levels plasma glucose (mg/dl) at 55th week were 156 ± 16 Group C, 252 18 L 349 93 H....