A5066777697- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Genetic and Kidney Cyst Diseases
- Vasculitis and related conditions
- Renal and related cancers
- Pancreatitis Pathology and Treatment
- Bone and Joint Diseases
- Aortic aneurysm repair treatments
- Pregnancy and preeclampsia studies
- Abdominal vascular conditions and treatments
- Dialysis and Renal Disease Management
- Autopsy Techniques and Outcomes
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Gut microbiota and health
- Blood properties and coagulation
- Gallbladder and Bile Duct Disorders
- Acute Ischemic Stroke Management
- Renal and Vascular Pathologies
- Iron Metabolism and Disorders
- Hemoglobinopathies and Related Disorders
- Erythropoietin and Anemia Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Ovarian function and disorders
- Biomedical Research and Pathophysiology
- Electroconvulsive Therapy Studies
Soka Municipal Hospital
2018-2023
Kyoto University
2017-2018
Juntendo University
2011-2017
Saitama International Medical Center
2007
Podocalyxin (PCX) is present on the apical cell membrane of podocytes and shed in urine from injured podocytes. Urinary podocalyxin (u-PCX) associated with severity active glomerular injury patients diseases. This study examined relationship between number urinary podocytes, levels u-PCX, adults IgA nephropathy (IgAN).Urine samples voided morning day biopsy were obtained 51 IgAN (18 men 33 women; mean age, 31 years). All renal specimens analyzed histologically. Pathologic variables per...
Adriamycin (ADR) nephrosis in mice has been extensively studied and enabled a greater understanding of the processes underlying progression renal injury. Dendrin is novel component slit diaphragm with proapoptotic signaling properties, it accumulates podocyte nucleus response to glomerular injury mice. The present study re-evaluated chronic progressive nephropathy ADR localization dendrin human glomerulopathy.To investigate dendrin, mouse model glomerulosclerosis was used, which injected...
The composition of the gut microbiome is altered in patients with chronic kidney disease (CKD). Dysbiosis leads to decreased levels stool organic acids (OAs) and systemic inflammation, followed by accumulation uremic toxins (UTs) development end-stage (ESKD). We assessed relationship between UT or ESKD comparing undergoing hemodialysis (HD) those normal renal function (NRF). This cross-sectional study recruited 41 HD 38 sex- age-matched NRF, microbiome, plasma UTs, inflammatory markers, OAs...
Background and Objectives Megalin is highly expressed at the apical membranes of proximal tubular epithelial cells. A urinary full-length megalin (C-megalin) assay linked to severity diabetic nephropathy in type 2 diabetes. This study examined relationship between levels C-megalin histological findings adult patients with IgA (IgAN). Design, Setting, Participants, & Measurements Urine samples voided morning on day renal biopsy were obtained from 73 IgAN (29 men 44 women; mean age, 33 years)...
It has been reported that podocytopenia occurring with increasing disease severity in patients IgA nephropathy (IgAN). Dendrin is localized at the slit diaphragm (SD) podocytes. We showed dendrin translocates to nucleus of injured podocytes experimental nephritis and nuclear promotes podocyte apoptosis. still unknown whether from SD IgAN. investigated presence IgAN association between translocated activity. Fourteen adult were enrolled. The pathological parameters analyzed. Immunostaining...
<i>Background:</i> In various animal studies, vitamin D has been shown to have a significant effect on reduction of proteinuria and the progression kidney disease. However, little is known its renoprotective in adriamycin (ADR)-induced nephrosis mice. The present study was intended determine therapeutic benefit 22-oxa-calcitriol (OCT), analog, reducing effect, i.e. preventing podocyte injury ADR-induced <i>Methods:</i> Three experimental groups were used as follows:...
<b><i>Background:</i></b> Blockade of the renin-angiotensin system plays a key role in suppressing progression renal diseases. It has not been well established whether this therapy provides additional effects when combined with vitamin D or its analog model adriamycin (ADR)-induced nephropathy. <b><i>Methods:</i></b> We evaluated effect an angiotensin II subtype 1 receptor blocker (telmisartan) (oxacalcitriol) on mice ADR-induced nephropathy...
Abstract Rac1, a Rho family member, is ubiquitously expressed and participates in various biological processes. Rac1 expression induced early podocyte injury, but its role repair unclear. To investigate the of podocytes under pathological conditions, we used podocyte-specific conditional knock-out (cKO) mice administered adriamycin (ADR), which causes nephrosis glomerulosclerosis. Larger areas detached podocytes, more adhesion GBM to Bowman’s capsule, higher ratio sclerotic glomeruli were...
ABSTRACT Background/Aims Hepcidin‐25 (HEP‐25) and erythroferrone (ERFE) are key regulators of iron homeostasis. Correlations among serum ferritin, ERFE HEP‐25 levels improvements in anaemia have not been evaluated after administration ferric citrate hydrate (FCH). Methods This retrospective observational study investigated 24 patients on haemodialysis with both (haemoglobin (Hb) < 12 g/dL) hyperphosphatemia (inorganic phosphorus ≥6 mg/dL). The who were administered FCH (1500 mg/day) for...
Abstract Ceftriaxone‐associated biliary pseudolithiasis is common among children; however, there are only a few reports of in adult patients on HD. This retrospective cohort study included 278 ceftriaxone therapy from 1 February 2016 to September 2018. Pseudolithiasis was defined as new development sludge or stones the gallbladder within 60 days therapy. After excluding with preexisting gallstones and history cholecystectomy, 113 maintenance HD, another 98 were enrolled HD control group,...
Abstract Recently, postmortem imaging is sometimes used as an alternative to conventional autopsy. However, there are few case reports of dialysis patients. Here, we report a fatal gas gangrene involving 76-year-old man who underwent dialysis. He died suddenly before diagnosis could be established. Immediately after his death, computed tomography (PMCT) revealed accumulation in right upper extremity and ascending aorta. Gas progresses rapidly may result sudden death it diagnosed. In this...
Abstract Background and Aims There are several reports that the initial (within one year) failure of vascular access (VA) is 2–53% in countries. Malnutrition alone, inflammation anemia alone factors have a well-known relationship to VA failure. We believe these risk complex one. Therefore, we evaluated whether addition had synergistic impact on Method This longitudinal cohort study sought confirm effects malnutrition, inflammation, included 177 patients with chronic kidney disease (CKD)...
Abstract Background and Aims Diffuse idiopathic skeletal hyperostosis (DISH) is an degenerative disease characterized by ossification of spinal ligaments entheses, especially in the anterior longitudinal ligament. The ankylosed spine prone to fracture with minor trauma may result cord injury. It usually asymptomatic often diagnosed incidentally computed tomography or other imaging methods. Several reports have revealed DISH as a risk factor for stroke, cardiovascular disease, metabolic...