A5032402076- Geometric and Algebraic Topology
- Advanced Combinatorial Mathematics
- Homotopy and Cohomology in Algebraic Topology
- semigroups and automata theory
- Computational Geometry and Mesh Generation
- Topological and Geometric Data Analysis
- Advanced Graph Theory Research
- Advanced Numerical Analysis Techniques
- Mathematics and Applications
- Behavioral Health and Interventions
- Graph theory and applications
- Advanced Algebra and Geometry
- Mathematical Dynamics and Fractals
- Stroke Rehabilitation and Recovery
- Data Management and Algorithms
- Connexins and lens biology
- Ion channel regulation and function
- Botulinum Toxin and Related Neurological Disorders
- Oral health in cancer treatment
- RNA Research and Splicing
- Physical Activity and Health
- Colorectal Cancer Treatments and Studies
- Logic, programming, and type systems
- Nicotinic Acetylcholine Receptors Study
- Functional Brain Connectivity Studies
Osaka Metropolitan University
2024
Hebei Rehabilitation Hospital
2020-2024
Hiroshima University
2011-2023
Kitasato University
2022-2023
Kobe Kaisei Hospital
2023
Shimane University
2020-2022
Doshisha University
2022
Hokkaido University of Science
2022
National Institute of Technology
2022
King Mongkut's Institute of Technology Ladkrabang
2022
Abstract Although the identification of late adolescents with subthreshold depression (StD) may provide a basis for developing effective interventions that could lead to reduction in prevalence StD and prevent development major depressive disorder, knowledge about neural remains limited. The purpose this study was develop generalizable classifier shed light on underlying mechanisms adolescents. Resting-state functional magnetic resonance imaging data 91 individuals (30 subjects, 61 healthy...
A region crossing change is a local transformation on knot or link diagram. We show that diagram an unknotting operation, and we define the number for knot.
For an oriented knot diagram D, the warping degree d(D) is smallest number of crossing changes which are needed to obtain monotone from D in usual way. We show that + d(-D) 1 less than or equal D. Moreover, equality holds if and only alternating diagram. a K, we also estimate minimum for all diagrams K with c(D) = c(K).
The constituent protein of gap junctions, connexin (Cx), interacts with various proteins via its C-terminus region, including kinases, cell-adhesion proteins, and a pro-apoptotic protein, Bax. This molecular interaction may affect expression functioning the interacting modulate cellular physiology. In our previous work, Cx43 was found to interact directly Bax in presence sunitinib, lead Bax-mediated apoptosis mesothelioma cells. this study, we investigated mechanism how promotes using same...
Potentially life‐threatening, serious hemoptysis is an adverse event associated with bevacizumab in non‐squamous non‐small‐cell lung cancer (NSCLC) trials. Suggested risk factors include central tumor location and cavitation; however, the profile of occurrence clinical practice still unclear. A nested case‐control study was conducted to assess onset for bevacizumab‐treated patients a real‐world setting Japan. After approved NSCLC, physicians registered all NSCLC scheduled therapy, from...
Abstract The main hypothesis for the relation between physical activity and mental health is that autonomous motivation, such as subjective pleasure activity, plays an important role. However, no report has described empirical research designed to examine role of in objectively measured psychological indexes. We used accelerometers collect data indicating participants' intensity during a week. Participants recorded their per hour. In 69% them, individual correlation coefficients hour (an...
The glucose-regulated protein (GRP78/BiP) and PKR-like endoplasmic reticulum kinase (PERK) plays a crucial role in the (ER) stress response.GRP78/BiP is highly elevated various human cancers.Our study to examine clinicopathological significance of GRP78/BiP PERK expression patients with tongue cancer.A total 85 cancer were analyzed, tumor specimens stained by immunohistochemistry for GRP78/BiP, PERK, GLUT1, Ki-67 microvessel density (MVD) determined CD34.GRP78/BiP expressed 47% 35% all...
Abstract Background Wearable devices have been widely used in research to understand the relationship between habitual physical activity and mental health real world. However, little attention has paid temporal variability continuous patterns measured by these devices. Therefore, we analyzed time-series of intensity a wearable device investigated its model parameters depression-related behaviors. Methods Sixty-six individuals for one week then answered questionnaire on A seasonal...
We show that any nontrivial reduced knot projection can be obtained from a trefoil by finite sequence of half-twisted splice operations and their inverses such the result each step in is reduced.
<p>The objective of this study was to identify pancreatic lipase inhibitory active ingredients mango leaves, and examine a relationship between leaves maturation activity. A methanolic extract old dark green (OML-ext) showed porcine The activity OML-ext attributable 3-C-<em>β</em>-D-glucosyl-2,4,4’,6-tetrahydroxybenzophenone (<strong>2</strong>) mangiferin (<strong>1</strong>). young leaf superior that extract. It suggested the is correlated with...
For an oriented link diagram $D$, the warping degree $d(D)$ is smallest number of crossing changes which are needed to obtain a monotone from $D$. We show that $d(D) + d(-D) \mathit{sr}(D)$ less than or equal where $-D$ denotes inverse $D$ and $\mathit{sr}(D)$ components have at least one self-crossing. Moreover, we give necessary sufficient condition for equality. also consider minimal all diagrams linking degree, some relations number, unknotting splitting number.
We introduce the warping polynomial of an oriented knot diagram. In this paper, we characterize polynomial, and define span a to be minimal for all diagrams knot. show that is one if only it non-trivial alternating, give inequality between dealternating number.
Abstract Objective This surveillance study was conducted to verify the post-market safety and effectiveness of bevacizumab, which approved in Japan 2013 for treatment patients with newly diagnosed or recurrent malignant glioma. Methods a prospective, observational, multicenter post-marketing study. Patients glioma scheduled bevacizumab were enrolled. The incidence severity adverse drug reactions calculated. assessed by 1-year survival rate overall rate. Results analysis set each comprised...
The tumor microenvironment is known to have increased levels of cytokines and metabolites, such as glutamate, due their release from the surrounding cells. A normal cell around that responds inflammatory environment likely be subsequently altered. We will discuss how these abnormalities support survival via actions gap junctions (GJs) hemichannels (HCs) which are composed hexamer connexin 43 (Cx43) protein. In particular, we GJ intercellular communication (GJIC) in glioma cells, primary...
Vaporization around the radiofrequency (RF) electrode after RF application (RFA) limits ablation area.To determine whether saturated saline injected into area of vaporization initial RFA extends further RFA.RFA was performed in 18 ex vivo porcine livers and four rabbit erector spinae muscles. An used to ablate an with 40W parallel current for 15 min. The margin determined using a thermocouple, radius ablated measured. After removal, infused through percutaneous ethanol injection needle site...
Region crossing change at a region of knot, link or spatial-graph diagram is local transformation which changes all the crossings on boundary region. In this paper, we show that can make any by finite number connected spatial graph has no cutting circles.
Region crossing change is a local transformation on knot or link diagram. We show that region diagram an unknotting operation, and we define the numbers for knot.
Adjuvant capecitabine and oxaliplatin (CAPOX) is a standard treatment for resected colon cancer; however, in patients with moderate renal impairment, the incidence of CAPOX-related adverse events (AEs) rate early discontinuation are higher than no or mild impairment. The aim this retrospective study was to assess impact baseline function on safety adjuvant CAPOX therapy started dose elderly cancer.Data from aged ≥65 years old who received at starting as stage II/III cancer were collected...