Darsiya Krishnathasan
A5083423388- COVID-19 Clinical Research Studies
- Venous Thromboembolism Diagnosis and Management
- Acute Ischemic Stroke Management
- Cardiovascular Disease and Adiposity
- COVID-19 Impact on Reproduction
- Healthcare Systems and Public Health
- Atrial Fibrillation Management and Outcomes
- COVID-19 and healthcare impacts
- Diabetes and associated disorders
- Artificial Intelligence in Healthcare
- Long-Term Effects of COVID-19
- Kawasaki Disease and Coronary Complications
- Cardiovascular Issues in Pregnancy
- Autism Spectrum Disorder Research
- Acute Myocardial Infarction Research
- Ultrasound in Clinical Applications
- SARS-CoV-2 and COVID-19 Research
- Blood groups and transfusion
- Central Venous Catheters and Hemodialysis
- Clinical practice guidelines implementation
- Obsessive-Compulsive Spectrum Disorders
- Child Development and Digital Technology
- Patient Safety and Medication Errors
- Dermatological and COVID-19 studies
- Chemotherapy-induced cardiotoxicity and mitigation
Brigham and Women's Hospital
2023-2025
Harvard University
2023-2025
Stony Brook University
2021
Importance Acute pulmonary embolism (PE) is a major cause of morbidity and mortality in patients with cancer the US worldwide. Objectives To assess trends PE-related from 2011 to 2020 among across age, sex, ethnic racial groups, urbanicity, regionality. Design, Setting, Participants This cohort study used Centers for Disease Control Prevention Wide-Ranging Online Data Epidemiologic Research data system determine national age-adjusted rates (AAMRs) due acute PE aged 15 years or older January...
Coronavirus disease 2019 (COVID-19) is associated with excess risk of cardiovascular and thrombotic events in the early post-infection period during convalescence. Despite progress our understanding complications, uncertainty persists respect to more recent event rates, temporal trends, association between vaccination status outcomes, findings within vulnerable subgroups such as older adults (aged 65 years or older), those undergoing hemodialysis. Sex-informed findings, including results...
IntroductionPregnancy may contribute to an excess risk of thrombotic or cardiovascular events. COVID-19 increases the these events, although is relatively limited among outpatients. We sought determine whether outpatient pregnant women with are at a high for events.Materials & methodsWe analyzed outpatients from multicenter CORONA-VTE-Network registry. The main study outcomes were composite adjudicated venous arterial and Events assessed 90 days after diagnosis reported non-pregnant ≤45...
Introduction: Patients with COVID-19 are at an increased risk of cardiovascular complications. Studies indicating association between ABO blood groups and outcomes were limited by small sample size or use administrative claims data uncertain validity. Aim: To study the non-O group among patients in a large cohort adjudicated events. Methods: We examined from CORONA-VTE Network registry confirmed data. The main outcome was major events including venous arterial thrombosis, heart failure,...
Background: Active cancer and COVID-19 are each independently associated with excess risk of thrombotic cardiovascular outcomes. Data limited regarding the these outcomes in patients both active COVID-19. Aim: To examine association between among Methods: from confirmed multicenter CORONA-VTE Network registry were used. was defined as having a malignancy diagnosis within past year or receiving related treatment. Outcomes adjudicated included (1) composite venous arterial thromboembolism (2)...
Background: Presentation, treatment and outcomes of pulmonary embolism (PE) in adults varies by age sex. Recently, some rule-based natural language processing (NLP) tools have been developed to detect PE from radiology reports. It is unknown whether variations sex influence the accuracy NLP models Methods: We used patient data Mass General Brigham (MGB) Health System between 2016 2021. The Verma et al. Johnson were applied reports determine among a randomly selected sample 1,712 patients...
Background: COVID-19 is a multiorgan disease characterized by prothrombotic state and increased risk of venous thromboembolism (VTE), especially in hospitalized patients. Although prior studies have attempted to identify predictors VTE, restricted sample size use administrative claims data limited such analyses. We conducted multivariable analysis VTE patients with multicenter patient-level registry. Methods: utilized from the CORONA-VTE Network, US registry 10,420 adult (≥18 years)...
Background: International Classification of Diseases, 10th Revision (ICD-10) discharge diagnosis codes are commonly used to identify patients with pulmonary embolism (PE) for research, surveillance, or quality improvement. Ethno-racial disparities exist in the presentation, treatment strategies, and outcomes PE, but it is unknown whether extend how PE coded electronic health records. Methods: The PE-EHR+ study was designed validate ICD-10 PE. We data from Mass General Brigham (MGB)....
Background: Some rule-based natural language processing (NLP) tools can identify pulmonary embolism (PE) from imaging reports. The external validity of these remains to be determined. Methods: We evaluated data for hospitalized patients the Mass General Brigham (MGB) Health System (2016-2021). NLP algorithms developed by Verma et al. and Johnson were implemented on radiology reports PE among 1,712 (mean age 60.6 years, 52.3% female). Previously, two models had demonstrated high diagnostic...
Introduction: Perceived high bleeding risk is the primary reason for withholding anticoagulation (AC) in patients with atrial fibrillation (AF). We performed AF-ALERT 2, a randomized controlled trial (RCT) of alert-based computerized decision support (CDS), to increase AC prescription high-risk outpatients AF. Method: analyzed 397 alert group this determine clinical characteristics and outcomes patients. 77 perceived as having too were compared 320 low risk. Results: was main providers...
Abstract Background Coronavirus disease 2019 (COVID-19) is associated with excess risk of cardiovascular events in the early post-infection period and during convalescence. Despite progress our understanding complications, uncertainty persists respect to contemporary event rates particularly given change viral variants COVID-19 therapies, as well availability vaccines later months pandemic. Purpose To report complications COVID-19, assess results by vaccination status from a large...