A5078560137- Studies on Chitinases and Chitosanases
- Invertebrate Immune Response Mechanisms
- Radiology practices and education
- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Protein Hydrolysis and Bioactive Peptides
- Mast cells and histamine
- Global Cancer Incidence and Screening
- Medical Imaging Techniques and Applications
- Digital Radiography and Breast Imaging
- AI in cancer detection
- Eosinophilic Esophagitis
- NF-κB Signaling Pathways
- Thyroid Disorders and Treatments
- Respiratory Support and Mechanisms
- Colorectal Cancer Screening and Detection
- Breast Cancer Treatment Studies
- Economic and Financial Impacts of Cancer
- Medical Coding and Health Information
- Cancer Risks and Factors
- Breast Lesions and Carcinomas
- Computational Drug Discovery Methods
- Monoclonal and Polyclonal Antibodies Research
- Peptidase Inhibition and Analysis
- Retinoids in leukemia and cellular processes
Novartis (United States)
2022
Emory University
2015-2021
Pfizer (United States)
2009-2021
Johns Hopkins University
2018
Emory Healthcare
2015
University of Southern California
2010
Inflammation Research Foundation
2009
Chronic obstructive pulmonary disease (COPD) remains a major cause of morbidity and mortality. Present-day diagnostic criteria are largely based solely on spirometric criteria. Accumulating evidence has identified substantial number individuals without COPD who suffer from respiratory symptoms and/or increased There is clear need for an expanded definition that linked to physiologic, structural (computed tomography [CT]) clinical disease. Using data the Genetic Epidemiology study (COPDGene
To investigate the role of PF-06650833, a highly potent and selective small-molecule inhibitor interleukin-1-associated kinase 4 (IRAK4), in autoimmune pathophysiology vitro, vivo, clinical setting.Rheumatoid arthritis (RA) inflammatory was modeled vitro through 1) stimulation primary human macrophages with anti-citrullinated protein antibody immune complexes (ICs), 2) RA fibroblast-like synoviocyte (FLS) cultures stimulated Toll-like receptor (TLR) ligands, as well 3) additional cell...
Interleukin-1 receptor–associated kinase 4 (IRAK4) plays a critical role in innate immune signaling by Toll-like receptors (TLRs), and loss of IRAK4 activity mice humans increases susceptibility to bacterial infections causes defects TLR IL1 ligand sensing. However, the mechanism which regulates production downstream inflammatory cytokines is unclear. Using transcriptomic biochemical analyses human monocytes treated with highly potent selective inhibitor IRAK4, we show that controls...
Human acidic mammalian chitinase (AMCase), a member of the family 18 glycosyl hydrolases, is one important proteins involved in Th2-mediated inflammation and has been implicated asthma allergic diseases. Inhibition AMCase results decreased airway hyper-responsiveness mouse model, suggesting that activity part mechanism Th2 cytokine-driven inflammatory response asthma. In this paper, we report first detailed kinetic characterization recombinant human AMCase. contrast with reported to have...
Acidic mammalian chitinase (AMCase) is a that has been implicated in allergic asthma. One of only two active chinases, AMCase, distinguished from other chitinases by several unique features. Here, we present the novel structure AMCase catalytic domain, both apo form and complex with inhibitor methylallosamidin, determined to high resolution X-ray crystallography. These results provide structural basis for understanding some characteristics this enzyme, including low pH optimum preference...
In asthma, mast cells infiltrate the airway smooth muscle cell layer and secrete proinflammatory profibrotic agents that contribute to remodeling. To study effects of activation on cell-dependent matrix contraction, we developed coculture systems human (HASM) with primary derived from circulating progenitors or HMC-1 line. Activation by IgE receptor cross-linking C5a stimulated contraction HASM-embedded collagen gels. Contractile activity could be transferred conditioned medium activated...
Abstract Is there a correlation between the 6‐min walk and aerobic fitness in children? We studied healthy cystic fibrosis (CF) subjects age 8–20 years using test, treadmill graded exercise stress spirometry. Six‐minute distance (6MWD) product of 6MWD body weight (6MWORK) were related to capacity. Data analyzed Student's t ‐test Pearson correlation. 13 [9 females, mean 15.8 ± 3.6 years, % predicted forced expiratory volume one second (FEV 1 ) 105 12%, 557 73 m, peak oxygen uptake ( ${\rm...
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The cytokine TWEAK and its cognate receptor Fn14 are members of the TNF/TNFR superfamily upregulated in tissue injury to mediate local responses including inflammation remodeling. We found that various models kidney disease, expression (mRNA protein) is kidney. These include: lupus nephritis mouse (Nephrotoxic serum Transfer Nephritis MRL.Faslpr/lpr), acute (Ischemia reperfusion Folic acid injury), a ZSF-1 diabetic nephropathy rat model. levels correlate with disease severity as measured by...
A central goal of the Academy Breastfeeding Medicine is development clinical protocols for managing common medical problems that may impact breastfeeding success. These serve only as guidelines care mothers and infants do not delineate an exclusive course treatment or standards care. Variations in be appropriate according to needs individual patient.
A diaryl ketone series was identified as vanin-1 inhibitors from a high-throughput screening campaign. While this novel scaffold provided valuable probe 2 that used to build target confidence, concerns over the moiety led replacement of group. The successful achieved with pyrimidine carboxamides derived cyclic secondary amines were extensively characterized using biophysical and crystallographic methods competitive vanin-1. Through optimization potency physicochemical ADME properties, guided...
Proteolysis of matrix components, in particular elastin, is a major contributing factor to the development lung diseases such as emphysema and chronic obstructive pulmonary disease (COPD). MMP-12 (macrophage elastase) protease known be involved progression disease. The relatively low abundance has precluded quantitative assays that can accurately measure protein levels activity across cohorts healthy diseased individuals. Commercial antibodies were screened for performance sandwich ELISA...
Low-pressure membranes provide high-quality water through physical removal of bacteria, cysts, and particles. Bacteria can attach to the membrane surface form biofilms that reduce energy efficiency increase frequency replacement. Modifying with polydopamine, a chemical mimic adhesive proteins mussels release, has potential delay biofilm formation. Dopamine polymerizes under mild conditions, forming coating is interest in applications due its hydrophilic reactive nature. Compared hydrophobic...
Patients often receive axillary ultrasound-biopsy (AUS-B) before clinical evaluation. One positive biopsy in the absence of palpable disease rarely indicates additional nodal involvement, but it eliminates patients from being managed by American College Surgeons Oncology Group Z0011 trial criteria. To determine which may benefit AUS-B, we analyzed whether characteristics on AUS were associated with large-volume and, thus, need for lymph node (LN) dissection. A retrospective review identified...