A5058762333- Zebrafish Biomedical Research Applications
- Hemophilia Treatment and Research
- Monoclonal and Polyclonal Antibodies Research
- Biosimilars and Bioanalytical Methods
- T-cell and B-cell Immunology
- Blood Coagulation and Thrombosis Mechanisms
- Galectins and Cancer Biology
- Blood properties and coagulation
- Fullerene Chemistry and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Graphene and Nanomaterials Applications
- T-cell and Retrovirus Studies
- Neuroscience and Neuropharmacology Research
- Glycosylation and Glycoproteins Research
- Cancer-related gene regulation
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Ear and Head Tumors
- Hearing, Cochlea, Tinnitus, Genetics
- Immunodeficiency and Autoimmune Disorders
- Angiogenesis and VEGF in Cancer
- Anesthesia and Neurotoxicity Research
- Phagocytosis and Immune Regulation
- Vitamin K Research Studies
- Peripheral Neuropathies and Disorders
- Protein purification and stability
Pfizer (United States)
2011-2021
Phylonix (United States)
2002-2011
Takeda (United States)
2010
Tonix Pharmaceuticals (United States)
2005-2007
Harvard University
2001
University of Massachusetts Amherst
1996-1997
The zebrafish embryo has become an important vertebrate model for assessing drug effects. It is well suited studies in genetics, embryology, development, and cell biology. Zebrafish embryos exhibit unique characteristics, including ease of maintenance administration, short reproductive cycle, transparency that permits visual assessment developing cells organs. Because these advantages, bioassays are cheaper faster than mouse assays, suitable large-scale screening. Here we describe the use...
In humans and mice, extensive gene rearrangement is the major mechanism of diversification primary Ig repertoire. This study shows that cattle depart from this pattern because in light chain locus sharply limited. Furthermore, cattle, conversion contributes to Sequencing germ-line expressed Vlambda genes revealed three important features. First, germ line contained a number pseudogenes. fact, 14 (70%) 20 identified sequenced were pseudogenes, they had one or more following defects: lack...
Using zebrafish (Danio rerio) embryos as a model system, we compared the antioxidant and cytoprotective effects of series new water-soluble fullerenes 1–12. Since are transparent during first week life, on multiple organ systems, including CNS, PNS, heart, could be assessed in situ. Both positively charged negatively were added at concentrations between 1 500 µM to 96 well plates containing 24–120 hours post fertilization (hpf). Direct toxicity each fullerene compound was by LC50. In...
A diaryl ketone series was identified as vanin-1 inhibitors from a high-throughput screening campaign. While this novel scaffold provided valuable probe 2 that used to build target confidence, concerns over the moiety led replacement of group. The successful achieved with pyrimidine carboxamides derived cyclic secondary amines were extensively characterized using biophysical and crystallographic methods competitive vanin-1. Through optimization potency physicochemical ADME properties, guided...
Dennis Keefe*a, Chuenlei Parnga, Dianna Lundberga, Satyajit Raya, Jennifer Martineau-Boscoa, Charan Lenga, Socrates Tzartosb, Jan Powella, Michael Concinoa, Heartleina, Justin Lamsaa & Serene Josiahaa Department of Research, Shire Human Genetic Therapies, Lexington, MA, 02421, USAb Biochemistry, Hellenic Pasteur Institute, Athens, 11521, Greece