A5084128881- Platelet Disorders and Treatments
- Complement system in diseases
- Blood groups and transfusion
- Malaria Research and Control
- Blood Coagulation and Thrombosis Mechanisms
- Mosquito-borne diseases and control
- Galectins and Cancer Biology
- Multiple Myeloma Research and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Hemophilia Treatment and Research
- Hydrogen's biological and therapeutic effects
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Healthcare and Venom Research
- Clusterin in disease pathology
- Ubiquitin and proteasome pathways
- Viral Infections and Vectors
- Bone Metabolism and Diseases
- Medical and Biological Ozone Research
- Cell Adhesion Molecules Research
- Protease and Inhibitor Mechanisms
- TGF-β signaling in diseases
- Immunodeficiency and Autoimmune Disorders
- Blood properties and coagulation
Institute of Molecular Medicine
2016-2022
St. James's Hospital
2015-2022
Trinity College Dublin
2013-2022
Royal College of Surgeons in Ireland
2008-2020
Dublin City University
2016
National Children’s Research Centre
2016
Children's Health Ireland at Crumlin
2016
Rockefeller University
2011-2013
UNSW Sydney
2011
Previous studies have demonstrated a role for plasmin in regulating plasma von Willebrand factor (VWF) multimer composition. Moreover, emerging data shown that plasmin-induced cleavage of VWF is particular importance specific pathological states. Interestingly, has been successfully used as an alternative to ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motif) mouse model thrombotic thrombocytopenic purpura. Consequently, elucidating the molecular mechanisms...
TF (tissue factor) is a transmembrane cofactor that initiates blood coagulation in mammals by binding Factor VIIa to activate Factors X and IX. The can reside cryptic configuration on primary cells de-encryption may involve redox change the C-terminal domain Cys186–Cys209 disulfide bond. potential of bond, spacing reduced cysteine thiols their oxidation activators was investigated test involvement dithiol/disulfide activation. A standard −278 mV determined for recombinant soluble TF....
Objective— Recent studies have demonstrated that galectin-1 (Gal-1) and galectin-3 (Gal-3) can bind von Willebrand factor directly modulate factor–dependent early thrombus formation in vivo. Because the glycans expressed on human VIII (FVIII) are similar to those of factor, we investigated whether galectins might also activity FVIII. Approach Results— Immunosorbant assays surface plasmon resonance analysis confirmed Gal-1 Gal-3 bound purified FVIII with high affinity. Exoglycosidase removal...
TGF-β1 is a disulfide-bonded homodimeric protein produced by platelets and other cells that plays role in many physiologic pathologic processes. secreted as an inactive large latent complex (LLC) comprised of TGF-β1, latency-associated peptide, TGF-β binding 1. We previously demonstrated shear force can activate LLC thiol-disulfide exchange contributes to the process. have now investigated thiol isomerases activation platelet releasates (PR) recombinant LLC. The wasp venom peptide...
Summary Adherence of infected erythrocytes to vascular endothelium causes acute endothelial cell (EC) activation during Plasmodium falciparum infection. Consequently, proteins stored in Weibel-Palade (WP) bodies within EC are secreted into the plasma. Osteoprotegerin (OPG) binds VWF and consequently is WP bodies. Given critical role pathogenesis severe malaria, we investigated plasma OPG levels children with P. malaria. At presentation, were significantly elevated cerebral malaria (CM)...
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