A5066789275- Hemophilia Treatment and Research
- Blood Coagulation and Thrombosis Mechanisms
- Platelet Disorders and Treatments
- Hemoglobinopathies and Related Disorders
- Cancer-related gene regulation
- Blood groups and transfusion
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Complement system in diseases
- Eosinophilic Disorders and Syndromes
- Medical Imaging Techniques and Applications
- Romani and Gypsy Studies
- Folate and B Vitamins Research
- Moyamoya disease diagnosis and treatment
- Protein Kinase Regulation and GTPase Signaling
- Alzheimer's disease research and treatments
- Cancer, Lipids, and Metabolism
- T-cell and B-cell Immunology
- Hemostasis and retained surgical items
- Blood disorders and treatments
- Helicobacter pylori-related gastroenterology studies
- Systemic Sclerosis and Related Diseases
- Bioactive Compounds and Antitumor Agents
- Venous Thromboembolism Diagnosis and Management
- S100 Proteins and Annexins
- Iron Metabolism and Disorders
St. James's Hospital
2000-2024
University of Pittsburgh
2015
Providence Hospital
2015
University College London
2015
Ixico (United Kingdom)
2015
University of Michigan
2015
Pfizer (United Kingdom)
2015
Pfizer (United States)
2015
Alzheimer’s Disease Neuroimaging Initiative
2015
Brigham and Women's Hospital
2015
This guideline updates the previous guidelines1, 2 published on behalf of British Society for Haematology (BSH) and United Kingdom Haemophilia Centre Doctors' Organisation (UKHCDO), focussing laboratory components diagnosis monitoring. Clinical aspects will be addressed in a separate guideline. was compiled according to BSH process at https://b-s-h.org.uk/media/16732/bsh-guidance-development-process-dec-5-18.pdf. The writing group, which comprised selected members Haemostasis Thrombosis Task...
Previous studies have reported marked interindividual variation in factor VIII (FVIII) clearance patients with hemophilia (PWH) and proposed a number of factors that influence this heterogeneity.To investigate the importance rates endogenous von Willebrand (VWF) compared those other FVIII half-life modifiers adult PWH.The recombinant was determined cohort 61 PWH. A range assessed (including plasma VWF:antigen VWF propeptide levels; VWF-FVIII binding capacity; ABO blood group; nonneutralizing...
Background Irish Travellers are an endogamous, nomadic, ethnic minority population mostly resident on the island of Ireland with smaller populations in Europe and USA. High levels consanguinity result many rare autosomal recessive disorders. Due to founder effects endogamy, most disorders caused by specific homozygous mutations unique this population. Key clinicians scientists experience managing seen have developed a de facto advisory service differential diagnoses consider when faced...
Haemophilia B generally arises as a result of unique mutations within the F9 gene and occurs with prevalence approximately one case per 30 000 males worldwide. The population haemophilia in Ireland at 12 500 is particularly high. To identify responsible for to define biological basis underlying increased Irish population, we performed sequence analysis 51 apparently unrelated kindred. In 18 kindred severe or moderate B, identified 14 different mutations; these occurred throughout included...
"Management of combined factor V and VIII deficiency in pregnancy." Journal Obstetrics Gynaecology, 39(2), pp. 271–272
The calcium-independent members of the protein kinase C (PKC) family may play a significant role in T cell function. We have characterized subcellular localization and redistribution activity two specific this (zeta epsilon) response to activation human peripheral blood lymphocytes with phorbol myristate acetate (PMA) or through TCR-CD3 complex. Both PMA OKT3, an antibody against TCR-associated CD3 complex, induce increase membrane cytoskeletal concomitant decrease cytosolic activity. By...
The prothrombin G20210A polymorphism is associated with a threefold-increased risk of venous thrombosis. There considerable variation in the reported prevalence this within normal populations, ranging from 0 to 6.5%. Irish population has not been determined. A restriction fragment length (RFLP)-based assay commonly used for detection 20210A allele. This does include control digest and, consequently, failure enzyme activity or lack addition sample cannot be distinguished wild-type...
The prevalence of factor V (FV) Leiden among normal populations has primarily been determined using blood donors. This control group is carefully selected and therefore may not accurately reflect the true within population. We assessed FV Irish population Guthrie card samples randomly from all newborns. compared this result with A novel nested polymerase chain reaction (PCR) method for was developed analysis samples. There no significant difference between allele frequency donors (2·07% vs....
The prevalence of factor V (FV) Leiden among normal populations has primarily been determined using blood donors. This control group is carefully selected and therefore may not accurately reflect the true within population. We assessed FV Irish population Guthrie card samples randomly from all newborns. compared this result with A novel nested polymerase chain reaction (PCR) method for was developed analysis samples. There no significant difference between allele frequency donors (2.07% vs....