A5056296628- Molecular Biology Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Economic and Financial Impacts of Cancer
- Pancreatic and Hepatic Oncology Research
- Global Cancer Incidence and Screening
- Gastric Cancer Management and Outcomes
- Lung Cancer Treatments and Mutations
- Health Systems, Economic Evaluations, Quality of Life
- Prostate Cancer Treatment and Research
- Breast Cancer Treatment Studies
- Head and Neck Cancer Studies
- Gastrointestinal Tumor Research and Treatment
- Cancer Diagnosis and Treatment
- Cancer survivorship and care
- Colorectal and Anal Carcinomas
- Esophageal Cancer Research and Treatment
- Prostate Cancer Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Surgical Treatments
- Multiple and Secondary Primary Cancers
- Advanced Radiotherapy Techniques
- Global Political and Economic Relations
- Metastasis and carcinoma case studies
- Neuroendocrine Tumor Research Advances
Emory University
2016-2025
Winship Cancer Institute
2013-2024
Ohio Department of Education
2023
John Wiley & Sons (United States)
2019-2021
Hudson Institute
2019-2021
University of New Mexico
2021
UNM Comprehensive Cancer Center
2021
New Mexico Cancer Center
2021
City of Hope
2021
Advanced Breast Care
2021
To compare perioperative outcomes of laparoscopic left-sided pancreatectomy (LLP) with traditional open (OLP) in a multicenter experience.LLP is being performed more commonly limited data comparing results from OLP.Data 8 centers were combined for all cases between 2002-2006. OLP and LLP cohorts matched by age, American Society Anesthesiologists, resected pancreas length, tumor size, diagnosis. Multivariate analysis was using binary logistic regression.Six hundred sixty-seven LPs performed,...
Limited data exist comparing robotic and open approaches to pancreaticoduodenectomy (PD). We performed a multicenter comparison of perioperative outcomes PD (RPD) (OPD).Perioperative for patients who underwent postlearning curve at 8 centers (8/2011-1/2015) were assessed. Univariate analyses clinicopathologic treatment factors performed, multivariable models constructed determine associations operative approach (RPD or OPD) with outcomes.Of the 1028 patients, 211 (20.5%) RPD (4.7%...
Prostate cancer remains the second leading cause of death in American men and there is an unmet need for biomarkers to identify patients with aggressive disease. In effort recurrence, we performed global RNA sequencing on 106 formalin-fixed, paraffin-embedded prostatectomy samples from 100 at three independent sites, defining a 24-gene signature panel. The 24 genes this panel function cell-cycle progression, angiogenesis, hypoxia, apoptosis, PI3K signaling, steroid metabolism, translation,...
BACKGROUND As systemic therapy has improved for locally advanced pancreatic cancer (LAPC), efforts to improve local control with optimal radiotherapy may be critical. Although conventionally fractionated radiation (CFRT) more recently shown a limited role in LAPC, stereotactic body (SBRT) is an emerging approach promising results. With no studies date comparing SBRT CFRT this study used the National Cancer Data Base (NCDB) evaluate these 2 modalities. METHODS NCDB, patients American Joint...
To analyze outcomes and predictors associated with proton radiation therapy for non-small cell lung cancer (NSCLC) in the National Cancer Database.The Database was queried to capture patients stage I-IV NSCLC treated thoracic from 2004 2012. A logistic regression model used determine utilization of therapy. The univariate multivariable association overall survival were assessed by Cox proportional hazards models along log-rank tests. propensity score matching method implemented balance...
BACKGROUND Stereotactic body radiation therapy (SBRT) has demonstrated high rates of local control with low morbidity and now emerged as the standard care for medically inoperable, early stage non–small cell lung cancer (NSCLC). However, impact SBRT on survival in elderly population is less clear given competing comorbid conditions. An analysis National Cancer Data Base (NCDB) was undertaken to determine whether definitive improves relative observation alone patients ages 70 years older....
Despite widespread utilization of immunotherapy, treating immune-cold tumors remains a challenge. Multiomic analyses and experimental validation identified the OTUD4/CD73 proteolytic axis as promising target in immune-suppressive triple negative breast cancer (TNBC). Mechanistically, deubiquitylation CD73 by OTUD4 counteracted its ubiquitylation TRIM21, resulting stabilization inhibiting tumor immune responses. We further demonstrated importance TGF-β signaling for orchestrating within...
BACKGROUND Postoperative management of prostate cancer with lymph node involvement (LNI) is controversial. Retrospective evidence supports the selective use radiotherapy (RT) after extended pelvic dissection. It unclear whether this generalizable to practice in United States, where dissection uncommon. The authors identified patients LNI who potentially could derive a survival benefit adjuvant RT plus androgen‐deprivation therapy (ADT). METHODS Patients N1M0 adenocarcinoma underwent radical...
Purpose: Medical gender confirmation therapy (GCT) plays an important role in transgender health; however, its prevalence and determinants constitute area of uncertainty. Methods: Data for this cross-sectional study were obtained from online survey distributed October 2012 through the end 2013 among persons who visited social media sites a education networking meeting. Eligible respondents (n=280) whose identity was different their sex assigned at birth responded to questions about...
Radical cystectomy currently remains the standard of care for muscle-invasive bladder cancer. However, surgery can be associated with considerable morbidity and mortality, including removal bladder. An alternative strategy is to preserve through concurrent chemoradiation following a maximal transurethral resection tumor. National protocols using bladder-preservation approach have demonstrated disease-specific outcomes comparable radical in selected patients, but these results not been...
Background The prognostic relevance of human papillomavirus (HPV) status in patients with nonoropharyngeal (OPX) squamous cell cancer (SCC) the head and neck is controversial. In current study, authors evaluated impact high‐risk HPV on overall survival (OS) non‐OPX SCC using a large database approach. Methods National Cancer Data Base was queried to identify diagnosed from 2004 through 2014 OPX, hypopharynx (HPX), larynx, oral cavity (OC) known status. Survival estimated Kaplan‐Meier...
Abstract Triple‐negative breast cancer (TNBC) in obese patients remains challenging. Recent studies have linked obesity to an increased risk of TNBC and malignancies. Through multiomic analysis experimental validation, a dysfunctional Eukaryotic Translation Initiation Factor 3 Subunit H (EIF3H)/Yes‐associated protein (YAP) proteolytic axis is identified as pivotal junction mediating the interplay between cancer‐associated adipocytes response anti‐cancer drugs TNBC. Mechanistically, drive...