A5019077694- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Cancer Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Salivary Gland Tumors Diagnosis and Treatment
- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Monoclonal and Polyclonal Antibodies Research
- Colorectal and Anal Carcinomas
- Tracheal and airway disorders
- Radiomics and Machine Learning in Medical Imaging
- Sinusitis and nasal conditions
- Ear and Head Tumors
- Infrared Thermography in Medicine
- Oral Health Pathology and Treatment
- Cleft Lip and Palate Research
- Meningioma and schwannoma management
- Immunotherapy and Immune Responses
- Optical Imaging and Spectroscopy Techniques
- Reconstructive Surgery and Microvascular Techniques
- Lung Cancer Diagnosis and Treatment
- Cancer-related gene regulation
- Multicomponent Synthesis of Heterocycles
Emory University
2016-2025
Piedmont Cancer Institute
2021-2025
Mosaic
2024
Winship Cancer Institute
2015-2024
Kamdhenu University
2024
Cooper Hospital
2017-2024
Emory Healthcare
2024
Duke University
2024
United States Army
2024
The University of Texas MD Anderson Cancer Center
2004-2023
Surgical cancer resection requires an accurate and timely diagnosis of the margins in order to achieve successful patient remission. Hyperspectral imaging (HSI) has emerged as a useful, noncontact technique for acquiring spectral optical properties tissue. A convolutional neural network (CNN) classifier is developed classify excised, squamous-cell carcinoma, thyroid cancer, normal head neck tissue samples using HSI. The CNN classification was validated by manual annotation pathologist...
As endoscopic skull base resections have advanced, appropriate reconstruction has become paramount. The reconstructive options for the include both avascular and vascular grafts. We review these provide an algorithm reconstruction. One hundred sixty-six dural defects, reconstructed with endonasal flap, were examined. adjunct, techniques are discussed to illustrate all Cerebrospinal fluid (CSF) leak rates also discussed. Small CSF leaks may be successfully repaired various grafting...
A prospective study of endoscopic expanded endonasal approaches (EEA) with nasoseptal flap reconstructions revealed anecdotal evidence less available relative septal length in pediatric patients. Our goal is to use radioanatomic analysis computed tomography (CT) scans determine limitations the skull base reconstruction and describe clinical outcomes after using six patients.Six patients who underwent EEA were prospectively analyzed for coverage postoperative cerebrospinal fluid (CSF) leak....
Abstract Objectives/Hypothesis: Preferred treatment of oral/plunging ranulas remains controversial. We present our experience with at the University North Carolina (UNC) and review literature. Methods: Retrospective review. From 1990 to 2007, 16 oral 10 plunging were treated UNC. Combining UNC series literature identified 864 cases for An online survey was conducted identify current patterns. Results: In series, procedures varied from ranula excision (50%), combined sublingual gland (44%),...
One of the major challenges cranial base surgery is reconstruction dural defect and prevention postoperative cerebrospinal fluid (CSF) fistula. The introduction endoscopic techniques an endonasal approach to ventral skull has created new for reconstruction.We have developed pericranial flap (PCF) hereby present initial cohort patients who had with a PCF after resection. We also demonstrate method radiographically incorporate anticipated defects preoperative planning length.Dural resection...
Endoscopic endonasal skull base surgery defects require effective reconstruction. Although the nasoseptal flap (NSF) has become our institution's workhorse for large with cerebrospinal fluid (CSF) leaks, situations where it is unavailable secondary flaps. Clinical outcomes, pearls and pitfalls, an algorithm will be presented these flaps.Clinical case series.Medical records of all endoscopic surgeries at a tertiary care academic medical center were reviewed defect type, reconstruction method,...
A label-free, hyperspectral imaging (HSI) approach has been proposed for tumor margin assessment. HSI data, i.e., hypercube (x,y,λ), consist of a series high-resolution images the same field view that are acquired at different wavelengths. Every pixel on an image optical spectrum. In this pilot clinical study, pipeline machine-learning-based quantification method data was implemented and evaluated in patient specimens. Spectral features from were used classification cancer normal tissue....
Purpose: This study intends to investigate the feasibility of using hyperspectral imaging (HSI) detect and delineate cancers in fresh, surgical specimens patients with head neck cancers.Experimental Design: A clinical was conducted order collect image from (N = 36) undergoing resection. set machine-learning tools were developed quantify images resected tissue cancerous regions which validated by histopathologic diagnosis. More than two million reflectance spectral signatures obtained HSI...
Robots navigating autonomously need to perceive and track the motion of objects other agents in its surroundings. This information enables planning executing robust safe trajectories. To facilitate these processes, should be perceived 3D Cartesian space. However, most recent multi-object tracking (MOT) research has focused on people moving 2D RGB video sequences. In this work we present JRMOT, a novel MOT system that integrates from images point clouds achieve real-time, state-of-the-art...
We present JRDB, a novel egocentric dataset collected from our social mobile manipulator JackRabbot. The includes 64 minutes of annotated multimodal sensor data including stereo cylindrical 360$^\circ$ RGB video at 15 fps, 3D point clouds two Velodyne 16 Lidars, line Sick audio signal, RGB-D 30 spherical image fisheye camera and encoder values the robot's wheels. Our incorporates traditionally underrepresented scenes such as indoor environments pedestrian areas, all ego-perspective robot,...
Abstract Objectives/Hypothesis: Pediatric skull base surgery is limited by several boney sinonasal landmarks that must be overcome prior to tumor dissection. When approaching a sellar or parasellar tumor, the piriform aperture, sphenoid sinus pneumatization, and intercarotid distances are areas of potential limitation. Quantitative pediatric anatomical measurements relevant approaches lacking. Our goal was use radio‐anatomic analysis computed tomography scans determine limitations for...
Abstract Purpose: Our previous work suggested that HER3 inhibition sensitizes head and neck squamous cell carcinoma (HNSCC) to EGFR with cetuximab. This study aimed define the role of in cetuximab resistance antitumor mechanisms EGFR/HER3 dual targeting HNSCC. Experimental Design: We treated cetuximab-resistant HNSCC UMSCC1-C parental UMSCC1-P lines anti-EGFR antibody cetuximab, anti-HER3 MM-121, their combination. assessed activities HER2, HER3, downstream signaling pathways by Western...
To propose a clinically applicable anatomic classification system describing three progressive endoscopic endonasal approaches (EEAs) to the infratemporal fossa (ITF) and their potential sequelae. Overall feasibility outcomes of these are presented through consecutive case series.Description for EEAs ITF series.A tumors was created based on senior author's clinical experience cadaveric dissection. A retrospective chart review 21 child adult patients with primary treated by from 2008 2012 at...
Management of cervical lymph node metastasis without a known primary tumor is diagnostic and treatment challenge for head neck oncologists. Identification the occult mucosal minimizes morbidity treatment.To analyze role transoral robotic surgery (TORS) in facilitating identification site patients presenting with squamous cell carcinoma unknown (CUP). In addition, we assessed deintensification by determining number who did not undergo definitive radiation therapy chemotherapy.In this...
<h3>BACKGROUND AND PURPOSE:</h3> The Head and Neck Imaging Reporting Data System (NI-RADS) surveillance template for head neck cancer includes a numeric assessment of suspicion recurrence (1–4) the primary site neck. Category 1 indicates no evidence recurrence; category 2, low 3, high 4, known recurrence. Our purpose was to evaluate performance NI-RADS scoring system predict local regional disease or persistence. <h3>MATERIALS METHODS:</h3> This study classified as quality-improvement...
Background The prognostic relevance of human papillomavirus (HPV) status in patients with nonoropharyngeal (OPX) squamous cell cancer (SCC) the head and neck is controversial. In current study, authors evaluated impact high‐risk HPV on overall survival (OS) non‐OPX SCC using a large database approach. Methods National Cancer Data Base was queried to identify diagnosed from 2004 through 2014 OPX, hypopharynx (HPX), larynx, oral cavity (OC) known status. Survival estimated Kaplan‐Meier...
6009 Background: E3311 is a phase II trial of TOS by credentialed surgeons with pathology-driven deintensified post-operative management in HPV+ OPC. Intermediate risk patients were randomized between standard and reduced dose radiation. We present mature outcome data, at median follow up 52.4 months (m). Methods: Patients eligible who had resectable cT1-2 stage III/IV AJCC7 p16+ OPC without matted neck nodes. Those clear margins, 0-1 + nodes (LN), no extranodal extension (ENE) observed (Arm...
Endoscopic ultrasound (EUS) is an accurate staging modality for esophageal malignancy. Studies have determined that EUS does not retain this accuracy after chemoradiation and it should be used as a restaging tool carcinoma. In study, the authors examined their experience with carcinoma neoadjuvant therapy EUS.A retrospective chart review was conducted included 83 patients locoregional adenocarcinoma who were treated under protocol. All underwent surgical resection. performed restaging,...
Abstract Purpose: We evaluated X-ray repair complementing defective in Chinese hamster cells 1 (XRCC1) protein head and neck squamous cell carcinoma (HNSCC) patients association with outcome. Experimental Design: XRCC1 expression was assessed by immunohistochemical (IHC) staining of pretreatment tissue samples 138 consecutive HNSCC treated surgery (n = 31), radiation (15), (23), adjuvant chemoradiation (17), primary (51), palliative measures (1). Results: Patients high IHC 77) compared low...